Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf^sup -/-^ mouse model

Inhibitors of double minute 2 protein (MDM2)-tumor protein 53 (TP53) interaction are predicted to be effective in tumors in which the TP53 gene is wild type, by preventing TP53 protein degradation. One such setting is represented by the frequent CDKN2A deletion in human cancer that, through inactiva...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-03, Vol.114 (12), p.3151
Hauptverfasser:	Chapeau, Emilie A, Gembarska, Agnieszka, Durand, Eric Y, Mandon, Emeline, Estadieu, Claire, Romanet, Vincent, Wiesmann, Marion, Tiedt, Ralph, Lehar, Joseph, de Weck, Antoine, Rad, Roland, Barys, Louise, Jeay, Sebastien, Ferretti, Stephane, Kauffmann, Audrey, Sutter, Esther, Grevot, Armelle, Moulin, Pierre, Murakami, Masato, Sellers, William R, Hofmann, Francesco, Jensen, Michael Rugaard
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug resistance Genetics Mutagenesis Pharmacology Protein expression Rodents Tumors
Online-Zugang:	Volltext
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