Synthesis and antiproliferative studies of curcumin pyrazole derivatives

A series of curcumin pyrazole derivatives ( 3a–e ) were synthesized. The chemical structures were determined by 1 H and 13 C NMR spectroscopic techniques and their purity was confirmed by LC–MS and melting point determination. The compounds were screened for anticancer effects on different cancer ce...

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Veröffentlicht in:	Medicinal chemistry research 2016-09, Vol.25 (9), p.1842-1851
Hauptverfasser:	Puneeth, Honnalagere Ramesh, Ananda, Hanumappa, Kumar, Kothanahally S. Sharath, Rangappa, Kanchugarakoppal S., Sharada, Angatahally Chandrashekariah
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antiproliferatives Biochemistry Biocompatibility Biomedical and Life Sciences Biomedicine Biotechnology Cancer Cell Biology Cell cycle Cell proliferation Chemical synthesis Curcumin Cytotoxicity Flow cytometry Fluorescence In vivo methods and tests Melting points Membrane potential Membranes Mitochondria NMR Nuclear magnetic resonance Original Research Pharmacology/Toxicology Pyrazole Toxicity Tumor cell lines
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