Leptin in normal physiology and leptin resistance
Since the discovery of leptin as an adipokine in 1994, much progress has been made in the research about leptin. Circulating leptin binds to leptin receptor, activates STAT3-dependent and STAT3-independent signaling pathways, and plays an effective role in energy homeostasis, neuroendocrine function...
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| Veröffentlicht in: | Science bulletin (Beijing) 2016-10, Vol.61 (19), p.1480-1488 |
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| container_title | Science bulletin (Beijing) |
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| creator | Li, Shufen Li, Xi |
| description | Since the discovery of leptin as an adipokine in 1994, much progress has been made in the research about leptin. Circulating leptin binds to leptin receptor, activates STAT3-dependent and STAT3-independent signaling pathways, and plays an effective role in energy homeostasis, neuroendocrine function and metabolism mainly through acting on the central nervous system, especially the hypothalamus. Leptin resistance is considered as a key risk factor for obesity. Various mechanisms have been formulated in order to explain leptin resistance, including impairment in leptin transport, attenuation in leptin signaling, ER stress, inflammation and deficiency in autophagy. Here, we review our current knowledge about leptin action, leptin signaling and leptin resistance, hoping to provide new ideas for the battle against obesity. |
| doi_str_mv | 10.1007/s11434-015-0951-4 |
| format | Article |
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Circulating leptin binds to leptin receptor, activates STAT3-dependent and STAT3-independent signaling pathways, and plays an effective role in energy homeostasis, neuroendocrine function and metabolism mainly through acting on the central nervous system, especially the hypothalamus. Leptin resistance is considered as a key risk factor for obesity. Various mechanisms have been formulated in order to explain leptin resistance, including impairment in leptin transport, attenuation in leptin signaling, ER stress, inflammation and deficiency in autophagy. 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| identifier | ISSN: 2095-9273 |
| ispartof | Science bulletin (Beijing), 2016-10, Vol.61 (19), p.1480-1488 |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Attenuation Central nervous system Chemistry/Food Science Earth Sciences Energy balance Energy homeostasis Engineering Homeostasis Humanities and Social Sciences Hypothalamus Leptin biology Leptin function Leptin resistance Leptin signaling Life Sciences Metabolism multidisciplinary Obesity Phagocytosis Physics Review Risk factors Science Science (multidisciplinary) STAT3 Stat3 protein 中枢神经系统 信号通路 内分泌功能 内质网应激 生理 瘦素受体 细胞因子 |
| title | Leptin in normal physiology and leptin resistance |
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