Evaluation of genotoxicity and oxidative stress of aluminium oxide nanoparticles and its bulk form in Allium cepa
In the present study, we examined the effects of aluminium oxide nanoparticles (Al 2 O 3 NPs) and bulk aluminium oxide (Al 2 O 3 ) on Allium cepa in terms of genotoxicity and oxidative stress responses under in planta conditions. The concentrations ranged from 1.25 to 5 µM for NP and its bulk form....
Gespeichert in:
| Veröffentlicht in: | Nucleus (Calcutta) 2016-12, Vol.59 (3), p.219-225 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 225 |
|---|---|
| container_issue | 3 |
| container_start_page | 219 |
| container_title | Nucleus (Calcutta) |
| container_volume | 59 |
| creator | De, Arpita Chakrabarti, Manoswini Ghosh, Ilika Mukherjee, Anita |
| description | In the present study, we examined the effects of aluminium oxide nanoparticles (Al
2
O
3
NPs) and bulk aluminium oxide (Al
2
O
3
) on
Allium cepa
in terms of genotoxicity and oxidative stress responses under
in planta
conditions. The concentrations ranged from 1.25 to 5 µM for NP and its bulk form. Results from this investigation indicated steady rise in chromosome aberrations, micronuclei and DNA strand breaks with increase in concentration of the NPs, effects of Al
2
O
3
NPs being significantly higher than those treated with bulk Al
2
O
3
. The divisional frequency was affected by the NP treatment. Oxidative damage such as lipid peroxidation and cell death to
Allium
under Al
2
O
3
NPs treatments was greater than that observed in bulk Al
2
O
3
. A significant increase in activity of guiacol peroxidase was observed in accordance with the depletion in catalase activity in both Al
2
O
3
NPs and bulk Al
2
O
3
treated plants as compared to control. In conclusion, the present study indicated that Al
2
O
3
NPs treatment exerted higher genotoxicity and oxidative stress responses on
A. cepa
than bulk Al
2
O
3
under
in planta
conditions. |
| doi_str_mv | 10.1007/s13237-016-0179-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1880859923</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1880859923</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-467e6e18cd62b86205611dc31f90a74bce34b962801d870ba4e3f36f84a9d70c3</originalsourceid><addsrcrecordid>eNp1kFtLwzAYhosoOHQ_wLuA19Uc2hwux5gHGHij4F1I23RktkmXpMP-e7PVC28MhHzwPs8XeLPsDsEHBCF7DIhgwnKIaLpM5NNFtoCC0ZwJVl6mGWKRl5R_XmfLEPYwnYJiRMtFdtgcVTeqaJwFrgU7bV1036Y2cQLKNiDNTUqPGoTodQgnKAm9sWbsz6kGVlk3KB9N3elwtkwMoBq7L9A63wNjwarrTnytB3WbXbWqC3r5-95kH0-b9_VLvn17fl2vtnlNEI15QZmmGvG6objiFMOSItSkrBVQsaKqNSkqQTGHqOEMVqrQpCW05YUSDYM1ucnu572Dd4dRhyj3bvQ2fSkR55CXQmCSKDRTtXcheN3KwZte-UkiKE_lyrlcmcqVp3LllBw8OyGxdqf9n83_Sj9AsX5l</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1880859923</pqid></control><display><type>article</type><title>Evaluation of genotoxicity and oxidative stress of aluminium oxide nanoparticles and its bulk form in Allium cepa</title><source>SpringerLink Journals - AutoHoldings</source><creator>De, Arpita ; Chakrabarti, Manoswini ; Ghosh, Ilika ; Mukherjee, Anita</creator><creatorcontrib>De, Arpita ; Chakrabarti, Manoswini ; Ghosh, Ilika ; Mukherjee, Anita</creatorcontrib><description>In the present study, we examined the effects of aluminium oxide nanoparticles (Al
2
O
3
NPs) and bulk aluminium oxide (Al
2
O
3
) on
Allium cepa
in terms of genotoxicity and oxidative stress responses under
in planta
conditions. The concentrations ranged from 1.25 to 5 µM for NP and its bulk form. Results from this investigation indicated steady rise in chromosome aberrations, micronuclei and DNA strand breaks with increase in concentration of the NPs, effects of Al
2
O
3
NPs being significantly higher than those treated with bulk Al
2
O
3
. The divisional frequency was affected by the NP treatment. Oxidative damage such as lipid peroxidation and cell death to
Allium
under Al
2
O
3
NPs treatments was greater than that observed in bulk Al
2
O
3
. A significant increase in activity of guiacol peroxidase was observed in accordance with the depletion in catalase activity in both Al
2
O
3
NPs and bulk Al
2
O
3
treated plants as compared to control. In conclusion, the present study indicated that Al
2
O
3
NPs treatment exerted higher genotoxicity and oxidative stress responses on
A. cepa
than bulk Al
2
O
3
under
in planta
conditions.</description><identifier>ISSN: 0029-568X</identifier><identifier>EISSN: 0976-7975</identifier><identifier>DOI: 10.1007/s13237-016-0179-y</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Aluminum ; Biomedical and Life Sciences ; Catalase ; Cell Biology ; Cell death ; Chromosome aberrations ; DNA damage ; Genotoxicity ; Life Sciences ; Lipid peroxidation ; Micronuclei ; Nanoparticles ; Original Article ; Oxidation ; Oxidative stress ; Peroxidase</subject><ispartof>Nucleus (Calcutta), 2016-12, Vol.59 (3), p.219-225</ispartof><rights>Archana Sharma Foundation of Calcutta 2016</rights><rights>Copyright Springer Science & Business Media 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-467e6e18cd62b86205611dc31f90a74bce34b962801d870ba4e3f36f84a9d70c3</citedby><cites>FETCH-LOGICAL-c316t-467e6e18cd62b86205611dc31f90a74bce34b962801d870ba4e3f36f84a9d70c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13237-016-0179-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13237-016-0179-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>De, Arpita</creatorcontrib><creatorcontrib>Chakrabarti, Manoswini</creatorcontrib><creatorcontrib>Ghosh, Ilika</creatorcontrib><creatorcontrib>Mukherjee, Anita</creatorcontrib><title>Evaluation of genotoxicity and oxidative stress of aluminium oxide nanoparticles and its bulk form in Allium cepa</title><title>Nucleus (Calcutta)</title><addtitle>Nucleus</addtitle><description>In the present study, we examined the effects of aluminium oxide nanoparticles (Al
2
O
3
NPs) and bulk aluminium oxide (Al
2
O
3
) on
Allium cepa
in terms of genotoxicity and oxidative stress responses under
in planta
conditions. The concentrations ranged from 1.25 to 5 µM for NP and its bulk form. Results from this investigation indicated steady rise in chromosome aberrations, micronuclei and DNA strand breaks with increase in concentration of the NPs, effects of Al
2
O
3
NPs being significantly higher than those treated with bulk Al
2
O
3
. The divisional frequency was affected by the NP treatment. Oxidative damage such as lipid peroxidation and cell death to
Allium
under Al
2
O
3
NPs treatments was greater than that observed in bulk Al
2
O
3
. A significant increase in activity of guiacol peroxidase was observed in accordance with the depletion in catalase activity in both Al
2
O
3
NPs and bulk Al
2
O
3
treated plants as compared to control. In conclusion, the present study indicated that Al
2
O
3
NPs treatment exerted higher genotoxicity and oxidative stress responses on
A. cepa
than bulk Al
2
O
3
under
in planta
conditions.</description><subject>Aluminum</subject><subject>Biomedical and Life Sciences</subject><subject>Catalase</subject><subject>Cell Biology</subject><subject>Cell death</subject><subject>Chromosome aberrations</subject><subject>DNA damage</subject><subject>Genotoxicity</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Micronuclei</subject><subject>Nanoparticles</subject><subject>Original Article</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Peroxidase</subject><issn>0029-568X</issn><issn>0976-7975</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kFtLwzAYhosoOHQ_wLuA19Uc2hwux5gHGHij4F1I23RktkmXpMP-e7PVC28MhHzwPs8XeLPsDsEHBCF7DIhgwnKIaLpM5NNFtoCC0ZwJVl6mGWKRl5R_XmfLEPYwnYJiRMtFdtgcVTeqaJwFrgU7bV1036Y2cQLKNiDNTUqPGoTodQgnKAm9sWbsz6kGVlk3KB9N3elwtkwMoBq7L9A63wNjwarrTnytB3WbXbWqC3r5-95kH0-b9_VLvn17fl2vtnlNEI15QZmmGvG6objiFMOSItSkrBVQsaKqNSkqQTGHqOEMVqrQpCW05YUSDYM1ucnu572Dd4dRhyj3bvQ2fSkR55CXQmCSKDRTtXcheN3KwZte-UkiKE_lyrlcmcqVp3LllBw8OyGxdqf9n83_Sj9AsX5l</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>De, Arpita</creator><creator>Chakrabarti, Manoswini</creator><creator>Ghosh, Ilika</creator><creator>Mukherjee, Anita</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20161201</creationdate><title>Evaluation of genotoxicity and oxidative stress of aluminium oxide nanoparticles and its bulk form in Allium cepa</title><author>De, Arpita ; Chakrabarti, Manoswini ; Ghosh, Ilika ; Mukherjee, Anita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-467e6e18cd62b86205611dc31f90a74bce34b962801d870ba4e3f36f84a9d70c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aluminum</topic><topic>Biomedical and Life Sciences</topic><topic>Catalase</topic><topic>Cell Biology</topic><topic>Cell death</topic><topic>Chromosome aberrations</topic><topic>DNA damage</topic><topic>Genotoxicity</topic><topic>Life Sciences</topic><topic>Lipid peroxidation</topic><topic>Micronuclei</topic><topic>Nanoparticles</topic><topic>Original Article</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Peroxidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De, Arpita</creatorcontrib><creatorcontrib>Chakrabarti, Manoswini</creatorcontrib><creatorcontrib>Ghosh, Ilika</creatorcontrib><creatorcontrib>Mukherjee, Anita</creatorcontrib><collection>CrossRef</collection><jtitle>Nucleus (Calcutta)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De, Arpita</au><au>Chakrabarti, Manoswini</au><au>Ghosh, Ilika</au><au>Mukherjee, Anita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of genotoxicity and oxidative stress of aluminium oxide nanoparticles and its bulk form in Allium cepa</atitle><jtitle>Nucleus (Calcutta)</jtitle><stitle>Nucleus</stitle><date>2016-12-01</date><risdate>2016</risdate><volume>59</volume><issue>3</issue><spage>219</spage><epage>225</epage><pages>219-225</pages><issn>0029-568X</issn><eissn>0976-7975</eissn><abstract>In the present study, we examined the effects of aluminium oxide nanoparticles (Al
2
O
3
NPs) and bulk aluminium oxide (Al
2
O
3
) on
Allium cepa
in terms of genotoxicity and oxidative stress responses under
in planta
conditions. The concentrations ranged from 1.25 to 5 µM for NP and its bulk form. Results from this investigation indicated steady rise in chromosome aberrations, micronuclei and DNA strand breaks with increase in concentration of the NPs, effects of Al
2
O
3
NPs being significantly higher than those treated with bulk Al
2
O
3
. The divisional frequency was affected by the NP treatment. Oxidative damage such as lipid peroxidation and cell death to
Allium
under Al
2
O
3
NPs treatments was greater than that observed in bulk Al
2
O
3
. A significant increase in activity of guiacol peroxidase was observed in accordance with the depletion in catalase activity in both Al
2
O
3
NPs and bulk Al
2
O
3
treated plants as compared to control. In conclusion, the present study indicated that Al
2
O
3
NPs treatment exerted higher genotoxicity and oxidative stress responses on
A. cepa
than bulk Al
2
O
3
under
in planta
conditions.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s13237-016-0179-y</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0029-568X |
| ispartof | Nucleus (Calcutta), 2016-12, Vol.59 (3), p.219-225 |
| issn | 0029-568X 0976-7975 |
| language | eng |
| recordid | cdi_proquest_journals_1880859923 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Aluminum Biomedical and Life Sciences Catalase Cell Biology Cell death Chromosome aberrations DNA damage Genotoxicity Life Sciences Lipid peroxidation Micronuclei Nanoparticles Original Article Oxidation Oxidative stress Peroxidase |
| title | Evaluation of genotoxicity and oxidative stress of aluminium oxide nanoparticles and its bulk form in Allium cepa |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T13%3A01%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20genotoxicity%20and%20oxidative%20stress%20of%20aluminium%20oxide%20nanoparticles%20and%20its%20bulk%20form%20in%20Allium%20cepa&rft.jtitle=Nucleus%20(Calcutta)&rft.au=De,%20Arpita&rft.date=2016-12-01&rft.volume=59&rft.issue=3&rft.spage=219&rft.epage=225&rft.pages=219-225&rft.issn=0029-568X&rft.eissn=0976-7975&rft_id=info:doi/10.1007/s13237-016-0179-y&rft_dat=%3Cproquest_cross%3E1880859923%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1880859923&rft_id=info:pmid/&rfr_iscdi=true |