Synthesis, biological screening and molecular docking studies of novel 4,6-pyrimidine derivatives as EGFR-TK inhibitors

Novel 4, 6-disubstituted pyrimidine derivatives (5–16) were synthesized in four steps starting from 2,4-dichloropyrimidine and screened for their cytotoxicity using brine shrimp ( Artemia Salina ) lethality bioassay. The compounds such as 6, 11, 14 and 15 were found to be more toxic. The compounds w...

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