Comparative biological evaluation between 99mTc(CO)3 and 99mTc-Sn (II) complexes of novel quinoline derivative: a promising infection radiotracer
A novel quinoline derivative, 2,2′-[(5-chloro-8-hydroxyquinoline-7-yl) methylazanediyl] diacetic acid (CHQMADA) was labeled with 99m Tc using SnCl 2 ·2H 2 O as a reducing agent to give a complex with a labeling yield 94 %. Also [ 99m Tc(H 2 O) 3 (CO) 3 ] + was prepared by heating at 100 °C for 30 mi...
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| Veröffentlicht in: | Journal of radioanalytical and nuclear chemistry 2017, Vol.311 (1), p.1-14 |
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| creator | Sanad, M. H. El-Bayoumy, A. S. A. Ibrahim, Alhussein A. |
| description | A novel quinoline derivative, 2,2′-[(5-chloro-8-hydroxyquinoline-7-yl) methylazanediyl] diacetic acid (CHQMADA) was labeled with
99m
Tc using SnCl
2
·2H
2
O as a reducing agent to give a complex with a labeling yield 94 %. Also [
99m
Tc(H
2
O)
3
(CO)
3
]
+
was prepared by heating at 100 °C for 30 min using 2 mg CHQMADA at pH 8 to give a labeling yield >99 %.
99m
Tc-(CO)
3
CHQMADA and
99m
Tc-Sn(II)-CHQMADA showed tissue uptake (target to non target T/NT = 6.80 ± 0.22) and (T/NT = 5.65 ± 0.34) respectively in
Escherichia coli
induced infection, which is higher than the commercially available
99m
Tc-ciprofloxacin (T/NT = 3.80 ± 0.80). In conclusion, both complexes were able to differentiate between septic and aseptic inflammation with superiority of [
99m
Tc-(CO)
3
CHQMADA]. |
| doi_str_mv | 10.1007/s10967-016-4945-8 |
| format | Article |
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99m
Tc using SnCl
2
·2H
2
O as a reducing agent to give a complex with a labeling yield 94 %. Also [
99m
Tc(H
2
O)
3
(CO)
3
]
+
was prepared by heating at 100 °C for 30 min using 2 mg CHQMADA at pH 8 to give a labeling yield >99 %.
99m
Tc-(CO)
3
CHQMADA and
99m
Tc-Sn(II)-CHQMADA showed tissue uptake (target to non target T/NT = 6.80 ± 0.22) and (T/NT = 5.65 ± 0.34) respectively in
Escherichia coli
induced infection, which is higher than the commercially available
99m
Tc-ciprofloxacin (T/NT = 3.80 ± 0.80). In conclusion, both complexes were able to differentiate between septic and aseptic inflammation with superiority of [
99m
Tc-(CO)
3
CHQMADA].</description><identifier>ISSN: 0236-5731</identifier><identifier>EISSN: 1588-2780</identifier><identifier>DOI: 10.1007/s10967-016-4945-8</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Carbon monoxide ; Chemistry ; Chemistry and Materials Science ; Diagnostic Radiology ; E coli ; Hadrons ; Heavy Ions ; Hydroxyquinoline ; Inorganic Chemistry ; Labeling ; Nuclear Chemistry ; Nuclear Physics ; Physical Chemistry ; Quinoline ; Radioactive tracers ; Reducing agents ; Technetium isotopes</subject><ispartof>Journal of radioanalytical and nuclear chemistry, 2017, Vol.311 (1), p.1-14</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2016</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1618-49a8a9c0d6dae255d811974c3c13e07cd6e263765082ed8bd71bd72b064bdca23</citedby><cites>FETCH-LOGICAL-c1618-49a8a9c0d6dae255d811974c3c13e07cd6e263765082ed8bd71bd72b064bdca23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10967-016-4945-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10967-016-4945-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Sanad, M. H.</creatorcontrib><creatorcontrib>El-Bayoumy, A. S. A.</creatorcontrib><creatorcontrib>Ibrahim, Alhussein A.</creatorcontrib><title>Comparative biological evaluation between 99mTc(CO)3 and 99mTc-Sn (II) complexes of novel quinoline derivative: a promising infection radiotracer</title><title>Journal of radioanalytical and nuclear chemistry</title><addtitle>J Radioanal Nucl Chem</addtitle><description>A novel quinoline derivative, 2,2′-[(5-chloro-8-hydroxyquinoline-7-yl) methylazanediyl] diacetic acid (CHQMADA) was labeled with
99m
Tc using SnCl
2
·2H
2
O as a reducing agent to give a complex with a labeling yield 94 %. Also [
99m
Tc(H
2
O)
3
(CO)
3
]
+
was prepared by heating at 100 °C for 30 min using 2 mg CHQMADA at pH 8 to give a labeling yield >99 %.
99m
Tc-(CO)
3
CHQMADA and
99m
Tc-Sn(II)-CHQMADA showed tissue uptake (target to non target T/NT = 6.80 ± 0.22) and (T/NT = 5.65 ± 0.34) respectively in
Escherichia coli
induced infection, which is higher than the commercially available
99m
Tc-ciprofloxacin (T/NT = 3.80 ± 0.80). In conclusion, both complexes were able to differentiate between septic and aseptic inflammation with superiority of [
99m
Tc-(CO)
3
CHQMADA].</description><subject>Carbon monoxide</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diagnostic Radiology</subject><subject>E coli</subject><subject>Hadrons</subject><subject>Heavy Ions</subject><subject>Hydroxyquinoline</subject><subject>Inorganic Chemistry</subject><subject>Labeling</subject><subject>Nuclear Chemistry</subject><subject>Nuclear Physics</subject><subject>Physical Chemistry</subject><subject>Quinoline</subject><subject>Radioactive tracers</subject><subject>Reducing agents</subject><subject>Technetium isotopes</subject><issn>0236-5731</issn><issn>1588-2780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1ULlOAzEQtRBIhOMD6CzRJMXCeA-vlw5FHJGQKAi15bUnkaONndhJgM_gj3GyFDQUo9GM3jHzCLlicMMA6tvIoOF1BoxnZVNWmTgiA1YJkeW1gGMygLzgWVUX7JScxbgAgEaIYkC-x365UkFt7A5pa33n51arjuJOddu09Y62uPlAdLRpllM9HL-OCqqc6cfszdHhZDKiOsl0-ImR-hl1focdXW-t8511SA0GuztY3FFFV8EvbbRuTq2boT54BGWs3wSlMVyQk5nqIl7-9nPy_vgwHT9nL69Pk_H9S6YZZyJ9qYRqNBhuFOZVZQRjTV3qQrMCodaGY86LmlcgcjSiNTVLlbfAy9ZolRfn5LrXTfestxg3cuG3wSVLyYQAAWUFexTrUTr4GAPO5CrYpQpfkoHcJy_75GVKXu6TlyJx8p4TE9bNMfxR_pf0Azhvh0E</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Sanad, M. H.</creator><creator>El-Bayoumy, A. S. A.</creator><creator>Ibrahim, Alhussein A.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2017</creationdate><title>Comparative biological evaluation between 99mTc(CO)3 and 99mTc-Sn (II) complexes of novel quinoline derivative: a promising infection radiotracer</title><author>Sanad, M. H. ; El-Bayoumy, A. S. A. ; Ibrahim, Alhussein A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1618-49a8a9c0d6dae255d811974c3c13e07cd6e263765082ed8bd71bd72b064bdca23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Carbon monoxide</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Diagnostic Radiology</topic><topic>E coli</topic><topic>Hadrons</topic><topic>Heavy Ions</topic><topic>Hydroxyquinoline</topic><topic>Inorganic Chemistry</topic><topic>Labeling</topic><topic>Nuclear Chemistry</topic><topic>Nuclear Physics</topic><topic>Physical Chemistry</topic><topic>Quinoline</topic><topic>Radioactive tracers</topic><topic>Reducing agents</topic><topic>Technetium isotopes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanad, M. H.</creatorcontrib><creatorcontrib>El-Bayoumy, A. S. A.</creatorcontrib><creatorcontrib>Ibrahim, Alhussein A.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanad, M. H.</au><au>El-Bayoumy, A. S. A.</au><au>Ibrahim, Alhussein A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative biological evaluation between 99mTc(CO)3 and 99mTc-Sn (II) complexes of novel quinoline derivative: a promising infection radiotracer</atitle><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle><stitle>J Radioanal Nucl Chem</stitle><date>2017</date><risdate>2017</risdate><volume>311</volume><issue>1</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>0236-5731</issn><eissn>1588-2780</eissn><abstract>A novel quinoline derivative, 2,2′-[(5-chloro-8-hydroxyquinoline-7-yl) methylazanediyl] diacetic acid (CHQMADA) was labeled with
99m
Tc using SnCl
2
·2H
2
O as a reducing agent to give a complex with a labeling yield 94 %. Also [
99m
Tc(H
2
O)
3
(CO)
3
]
+
was prepared by heating at 100 °C for 30 min using 2 mg CHQMADA at pH 8 to give a labeling yield >99 %.
99m
Tc-(CO)
3
CHQMADA and
99m
Tc-Sn(II)-CHQMADA showed tissue uptake (target to non target T/NT = 6.80 ± 0.22) and (T/NT = 5.65 ± 0.34) respectively in
Escherichia coli
induced infection, which is higher than the commercially available
99m
Tc-ciprofloxacin (T/NT = 3.80 ± 0.80). In conclusion, both complexes were able to differentiate between septic and aseptic inflammation with superiority of [
99m
Tc-(CO)
3
CHQMADA].</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10967-016-4945-8</doi><tpages>14</tpages></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Carbon monoxide Chemistry Chemistry and Materials Science Diagnostic Radiology E coli Hadrons Heavy Ions Hydroxyquinoline Inorganic Chemistry Labeling Nuclear Chemistry Nuclear Physics Physical Chemistry Quinoline Radioactive tracers Reducing agents Technetium isotopes |
| title | Comparative biological evaluation between 99mTc(CO)3 and 99mTc-Sn (II) complexes of novel quinoline derivative: a promising infection radiotracer |
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