Molecular design of multitarget neuroprotectors 2. Synthesis and bioactivity of carbazole—γ-carboline conjugates
Earlier unknown conjugates of carbazoles and γ-carbolines were obtained by the reaction of 3,6-substituted 9-oxiranylmethylcarbazoles and 2,8-substituted 2,3,4,5-tetrahydro-1 H -pyrido-[4,3]indoles. The effects of synthesized 1-(9 H -carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5 H -pyrido-[4,3- b ]indol-5-...
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| Veröffentlicht in: | Russian chemical bulletin 2016-05, Vol.65 (5), p.1346-1353 |
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| container_title | Russian chemical bulletin |
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| creator | Sokolov, V. B. Aksinenko, A. Yu Goreva, T. V. Epishina, T. A. Grigor´ev, V. V. Gabrel´yan, A. V. Vinogradova, D. V. Dubova, L. G. Shevtsov, P. N. Shevtsova, E. F. Bachurin, S. O. |
| description | Earlier unknown conjugates of carbazoles and γ-carbolines were obtained by the reaction of 3,6-substituted 9-oxiranylmethylcarbazoles and 2,8-substituted 2,3,4,5-tetrahydro-1
H
-pyrido-[4,3]indoles. The effects of synthesized 1-(9
H
-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5
H
-pyrido-[4,3-
b
]indol-5-yl)propan-2-ones and their hydrochlorides on neuronal NMDA receptors, polymerization of tubulin to form microtubules, and functional characteristics of rat liver mitochondria were studied. |
| doi_str_mv | 10.1007/s11172-016-1460-6 |
| format | Article |
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H
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H
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b
]indol-5-yl)propan-2-ones and their hydrochlorides on neuronal NMDA receptors, polymerization of tubulin to form microtubules, and functional characteristics of rat liver mitochondria were studied.</description><subject>Biocompatibility</subject><subject>Carbazoles</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Conjugates</subject><subject>Full Articles</subject><subject>Hydrochlorides</subject><subject>Indoles</subject><subject>Inorganic Chemistry</subject><subject>Liver</subject><subject>Mitochondria</subject><subject>Organic Chemistry</subject><subject>Polymerization</subject><subject>Receptors</subject><issn>1066-5285</issn><issn>1573-9171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kEtOwzAQhiMEEqVwAHaWWLt48nDsJap4SUUsgLXlOpOSKo2L7SCVFYfgJtyDQ3ASHIUFG1YeS9_3z-hPklNgM2CsPPcAUKaUAaeQc0b5XjKBosyohBL248w4p0UqisPkyPs1YywVQkwSf2dbNH2rHanQN6uO2Jps-jY0QbsVBtJh7-zW2YAmWOdJOiMPuy48R9gT3VVk2VhtQvPahN3gGu2W-i2Gfr9_fH3S4WvbpkNibLfuVzqgP04Oat16PPl9p8nT1eXj_IYu7q9v5xcLajLggQIyDbLW9VLXsoCC8YojMlOKEjQ3vMoqCTLPTYGcl5XUBUOs0ywVWS6rusimydmYG89_6dEHtba96-JKBUKwUqZMyEjBSBlnvXdYq61rNtrtFDA1dKvGblXsVg3dKh6ddHR8ZLsVuj_J_0o_XdqATA</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Sokolov, V. B.</creator><creator>Aksinenko, A. Yu</creator><creator>Goreva, T. V.</creator><creator>Epishina, T. A.</creator><creator>Grigor´ev, V. V.</creator><creator>Gabrel´yan, A. V.</creator><creator>Vinogradova, D. V.</creator><creator>Dubova, L. G.</creator><creator>Shevtsov, P. N.</creator><creator>Shevtsova, E. F.</creator><creator>Bachurin, S. O.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20160501</creationdate><title>Molecular design of multitarget neuroprotectors 2. Synthesis and bioactivity of carbazole—γ-carboline conjugates</title><author>Sokolov, V. B. ; Aksinenko, A. Yu ; Goreva, T. V. ; Epishina, T. A. ; Grigor´ev, V. V. ; Gabrel´yan, A. V. ; Vinogradova, D. V. ; Dubova, L. G. ; Shevtsov, P. N. ; Shevtsova, E. F. ; Bachurin, S. O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-1e0a19fafbaf951506d6ee0c7871a6c6d3d91944c5e667d9a50eef2328349df53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biocompatibility</topic><topic>Carbazoles</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Conjugates</topic><topic>Full Articles</topic><topic>Hydrochlorides</topic><topic>Indoles</topic><topic>Inorganic Chemistry</topic><topic>Liver</topic><topic>Mitochondria</topic><topic>Organic Chemistry</topic><topic>Polymerization</topic><topic>Receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sokolov, V. B.</creatorcontrib><creatorcontrib>Aksinenko, A. Yu</creatorcontrib><creatorcontrib>Goreva, T. V.</creatorcontrib><creatorcontrib>Epishina, T. A.</creatorcontrib><creatorcontrib>Grigor´ev, V. V.</creatorcontrib><creatorcontrib>Gabrel´yan, A. V.</creatorcontrib><creatorcontrib>Vinogradova, D. V.</creatorcontrib><creatorcontrib>Dubova, L. G.</creatorcontrib><creatorcontrib>Shevtsov, P. N.</creatorcontrib><creatorcontrib>Shevtsova, E. F.</creatorcontrib><creatorcontrib>Bachurin, S. O.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian chemical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sokolov, V. B.</au><au>Aksinenko, A. Yu</au><au>Goreva, T. V.</au><au>Epishina, T. A.</au><au>Grigor´ev, V. V.</au><au>Gabrel´yan, A. V.</au><au>Vinogradova, D. V.</au><au>Dubova, L. G.</au><au>Shevtsov, P. N.</au><au>Shevtsova, E. F.</au><au>Bachurin, S. O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular design of multitarget neuroprotectors 2. Synthesis and bioactivity of carbazole—γ-carboline conjugates</atitle><jtitle>Russian chemical bulletin</jtitle><stitle>Russ Chem Bull</stitle><date>2016-05-01</date><risdate>2016</risdate><volume>65</volume><issue>5</issue><spage>1346</spage><epage>1353</epage><pages>1346-1353</pages><issn>1066-5285</issn><eissn>1573-9171</eissn><abstract>Earlier unknown conjugates of carbazoles and γ-carbolines were obtained by the reaction of 3,6-substituted 9-oxiranylmethylcarbazoles and 2,8-substituted 2,3,4,5-tetrahydro-1
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| subjects | Biocompatibility Carbazoles Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Conjugates Full Articles Hydrochlorides Indoles Inorganic Chemistry Liver Mitochondria Organic Chemistry Polymerization Receptors |
| title | Molecular design of multitarget neuroprotectors 2. Synthesis and bioactivity of carbazole—γ-carboline conjugates |
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