Magnetic nanoparticles are highly toxic to chloroquine-resistant Plasmodium falciparum, dengue virus (DEN-2), and their mosquito vectors
A main challenge in parasitology is the development of reliable tools to prevent or treat mosquito-borne diseases. We investigated the toxicity of magnetic nanoparticles (MNP) produced by Magnetospirillum gryphiswaldense (strain MSR-1) on chloroquine-resistant (CQ-r) and sensitive (CQ-s) Plasmodium...
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| creator | Murugan, Kadarkarai Wei, Jiang Alsalhi, Mohamad Saleh Nicoletti, Marcello Paulpandi, Manickam Samidoss, Christina Mary Dinesh, Devakumar Chandramohan, Balamurugan Paneerselvam, Chellasamy Subramaniam, Jayapal Vadivalagan, Chithravel Wei, Hui Amuthavalli, Pandiyan Jaganathan, Anitha Devanesan, Sandhanasamy Higuchi, Akon Kumar, Suresh Aziz, Al Thabiani Nataraj, Devaraj Vaseeharan, Baskaralingam Canale, Angelo Benelli, Giovanni |
| description | A main challenge in parasitology is the development of reliable tools to prevent or treat mosquito-borne diseases. We investigated the toxicity of magnetic nanoparticles (MNP) produced by
Magnetospirillum gryphiswaldense
(strain MSR-1) on chloroquine-resistant (CQ-r) and sensitive (CQ-s)
Plasmodium falciparum
, dengue virus (DEN-2), and two of their main vectors,
Anopheles stephensi
and
Aedes aegypti
, respectively. MNP were studied by Fourier-transform infrared spectroscopy and transmission electron microscopy. They were toxic to larvae and pupae of
An. stephensi
, LC
50
ranged from 2.563 ppm (1st instar larva) to 6.430 ppm (pupa), and
Ae. aegypti
, LC
50
ranged from 3.231 ppm (1st instar larva) to 7.545 ppm (pupa). MNP IC
50
on
P. falciparum
were 83.32 μg ml
−1
(CQ-s) and 87.47 μg ml
−1
(CQ-r). However, the in vivo efficacy of MNP on
Plasmodium berghei
was low if compared to CQ-based treatments. Moderate cytotoxicity was detected on Vero cells post-treatment with MNP doses lower than 4 μg ml
−1
. MNP evaluated at 2–8 μg ml
−1
inhibited DEN-2 replication inhibiting the expression of the envelope (E) protein. In conclusion, our findings represent the first report about the use of MNP in medical and veterinary entomology, proposing them as suitable materials to develop reliable tools to combat mosquito-borne diseases. |
| doi_str_mv | 10.1007/s00436-016-5310-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_1880790930</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A550917201</galeid><sourcerecordid>A550917201</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-45a9b0c1824bee1a0875773a306b8682653100e9f9ba830be14d886a68ab44423</originalsourceid><addsrcrecordid>eNp1UU1v1TAQtBCIPgo_gAuyxKVITVknTuwcq1I-pBY4wNlynE2eq8R-2E5F_wE_G0evtCBR-eCVd2a8s0PISwYnDEC8jQC8agpgTVFXDAp4RDaMV2XB2rp-TDbQ5hoYqw7IsxivAJhoOH9KDkohWS2qZkN-XerRYbKGOu38TodcThipDki3dtxONzT5n7mdPDXbyQf_Y7EOi4DRxqRdol8nHWff22Wmg56MzRrLfEx7dOOC9NqGJdKjd-efi_LNMdWup2mLNtDZx6yUVa_RJB_ic_Ik0yO-uL0Pyff359_OPhYXXz58Oju9KAyXZSp4rdsODJMl7xCZBilqISpdQdPJRpbNugjAdmg7LSvokPFeykY3Unec87I6JK_3urvVCsakrvwSXP5SMSlBtHlpcI8a9YTKusGnoM1so1GndQ0tEyWwjDr5DyqfHmdrvMPB5vd_CGxPMMHHGHBQu2BnHW4UA7VGqvaRqhypWp2odZRXtwMv3Yz9HeNPhhlQ7gExt9yI4S9HD6r-BifBqrc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1880790930</pqid></control><display><type>article</type><title>Magnetic nanoparticles are highly toxic to chloroquine-resistant Plasmodium falciparum, dengue virus (DEN-2), and their mosquito vectors</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Murugan, Kadarkarai ; Wei, Jiang ; Alsalhi, Mohamad Saleh ; Nicoletti, Marcello ; Paulpandi, Manickam ; Samidoss, Christina Mary ; Dinesh, Devakumar ; Chandramohan, Balamurugan ; Paneerselvam, Chellasamy ; Subramaniam, Jayapal ; Vadivalagan, Chithravel ; Wei, Hui ; Amuthavalli, Pandiyan ; Jaganathan, Anitha ; Devanesan, Sandhanasamy ; Higuchi, Akon ; Kumar, Suresh ; Aziz, Al Thabiani ; Nataraj, Devaraj ; Vaseeharan, Baskaralingam ; Canale, Angelo ; Benelli, Giovanni</creator><creatorcontrib>Murugan, Kadarkarai ; Wei, Jiang ; Alsalhi, Mohamad Saleh ; Nicoletti, Marcello ; Paulpandi, Manickam ; Samidoss, Christina Mary ; Dinesh, Devakumar ; Chandramohan, Balamurugan ; Paneerselvam, Chellasamy ; Subramaniam, Jayapal ; Vadivalagan, Chithravel ; Wei, Hui ; Amuthavalli, Pandiyan ; Jaganathan, Anitha ; Devanesan, Sandhanasamy ; Higuchi, Akon ; Kumar, Suresh ; Aziz, Al Thabiani ; Nataraj, Devaraj ; Vaseeharan, Baskaralingam ; Canale, Angelo ; Benelli, Giovanni</creatorcontrib><description>A main challenge in parasitology is the development of reliable tools to prevent or treat mosquito-borne diseases. We investigated the toxicity of magnetic nanoparticles (MNP) produced by
Magnetospirillum gryphiswaldense
(strain MSR-1) on chloroquine-resistant (CQ-r) and sensitive (CQ-s)
Plasmodium falciparum
, dengue virus (DEN-2), and two of their main vectors,
Anopheles stephensi
and
Aedes aegypti
, respectively. MNP were studied by Fourier-transform infrared spectroscopy and transmission electron microscopy. They were toxic to larvae and pupae of
An. stephensi
, LC
50
ranged from 2.563 ppm (1st instar larva) to 6.430 ppm (pupa), and
Ae. aegypti
, LC
50
ranged from 3.231 ppm (1st instar larva) to 7.545 ppm (pupa). MNP IC
50
on
P. falciparum
were 83.32 μg ml
−1
(CQ-s) and 87.47 μg ml
−1
(CQ-r). However, the in vivo efficacy of MNP on
Plasmodium berghei
was low if compared to CQ-based treatments. Moderate cytotoxicity was detected on Vero cells post-treatment with MNP doses lower than 4 μg ml
−1
. MNP evaluated at 2–8 μg ml
−1
inhibited DEN-2 replication inhibiting the expression of the envelope (E) protein. In conclusion, our findings represent the first report about the use of MNP in medical and veterinary entomology, proposing them as suitable materials to develop reliable tools to combat mosquito-borne diseases.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-016-5310-0</identifier><identifier>PMID: 27815736</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aedes - drug effects ; Aedes - physiology ; Aedes aegypti ; Animals ; Anopheles - drug effects ; Anopheles - physiology ; Anopheles stephensi ; Biomedical and Life Sciences ; Biomedicine ; Cercopithecus aethiops ; Chloroquine ; Chloroquine - pharmacology ; Cytotoxicity ; Dengue fever ; Dengue virus ; Dengue Virus - drug effects ; Dengue Virus - physiology ; Disease transmission ; Drug Resistance ; Electron microscopy ; Erythrocytes ; Fourier transforms ; Immunology ; Infrared spectroscopy ; Insecticides - pharmacology ; Larvae ; Magnetic properties ; Magnetite Nanoparticles - toxicity ; Magnetospirillum gryphiswaldense ; Malaria ; Medical Microbiology ; Microbiology ; Mosquito Vectors - drug effects ; Mosquito Vectors - physiology ; Mosquitoes ; Nanoparticles ; Original Paper ; Physiological aspects ; Plasmodium berghei ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; Plasmodium falciparum - physiology ; Pupae ; Toxicity ; Transmission electron microscopy ; Vectors ; Vero Cells</subject><ispartof>Parasitology research (1987), 2017-02, Vol.116 (2), p.495-502</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-45a9b0c1824bee1a0875773a306b8682653100e9f9ba830be14d886a68ab44423</citedby><cites>FETCH-LOGICAL-c482t-45a9b0c1824bee1a0875773a306b8682653100e9f9ba830be14d886a68ab44423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00436-016-5310-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00436-016-5310-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27815736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murugan, Kadarkarai</creatorcontrib><creatorcontrib>Wei, Jiang</creatorcontrib><creatorcontrib>Alsalhi, Mohamad Saleh</creatorcontrib><creatorcontrib>Nicoletti, Marcello</creatorcontrib><creatorcontrib>Paulpandi, Manickam</creatorcontrib><creatorcontrib>Samidoss, Christina Mary</creatorcontrib><creatorcontrib>Dinesh, Devakumar</creatorcontrib><creatorcontrib>Chandramohan, Balamurugan</creatorcontrib><creatorcontrib>Paneerselvam, Chellasamy</creatorcontrib><creatorcontrib>Subramaniam, Jayapal</creatorcontrib><creatorcontrib>Vadivalagan, Chithravel</creatorcontrib><creatorcontrib>Wei, Hui</creatorcontrib><creatorcontrib>Amuthavalli, Pandiyan</creatorcontrib><creatorcontrib>Jaganathan, Anitha</creatorcontrib><creatorcontrib>Devanesan, Sandhanasamy</creatorcontrib><creatorcontrib>Higuchi, Akon</creatorcontrib><creatorcontrib>Kumar, Suresh</creatorcontrib><creatorcontrib>Aziz, Al Thabiani</creatorcontrib><creatorcontrib>Nataraj, Devaraj</creatorcontrib><creatorcontrib>Vaseeharan, Baskaralingam</creatorcontrib><creatorcontrib>Canale, Angelo</creatorcontrib><creatorcontrib>Benelli, Giovanni</creatorcontrib><title>Magnetic nanoparticles are highly toxic to chloroquine-resistant Plasmodium falciparum, dengue virus (DEN-2), and their mosquito vectors</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>A main challenge in parasitology is the development of reliable tools to prevent or treat mosquito-borne diseases. We investigated the toxicity of magnetic nanoparticles (MNP) produced by
Magnetospirillum gryphiswaldense
(strain MSR-1) on chloroquine-resistant (CQ-r) and sensitive (CQ-s)
Plasmodium falciparum
, dengue virus (DEN-2), and two of their main vectors,
Anopheles stephensi
and
Aedes aegypti
, respectively. MNP were studied by Fourier-transform infrared spectroscopy and transmission electron microscopy. They were toxic to larvae and pupae of
An. stephensi
, LC
50
ranged from 2.563 ppm (1st instar larva) to 6.430 ppm (pupa), and
Ae. aegypti
, LC
50
ranged from 3.231 ppm (1st instar larva) to 7.545 ppm (pupa). MNP IC
50
on
P. falciparum
were 83.32 μg ml
−1
(CQ-s) and 87.47 μg ml
−1
(CQ-r). However, the in vivo efficacy of MNP on
Plasmodium berghei
was low if compared to CQ-based treatments. Moderate cytotoxicity was detected on Vero cells post-treatment with MNP doses lower than 4 μg ml
−1
. MNP evaluated at 2–8 μg ml
−1
inhibited DEN-2 replication inhibiting the expression of the envelope (E) protein. In conclusion, our findings represent the first report about the use of MNP in medical and veterinary entomology, proposing them as suitable materials to develop reliable tools to combat mosquito-borne diseases.</description><subject>Aedes - drug effects</subject><subject>Aedes - physiology</subject><subject>Aedes aegypti</subject><subject>Animals</subject><subject>Anopheles - drug effects</subject><subject>Anopheles - physiology</subject><subject>Anopheles stephensi</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cercopithecus aethiops</subject><subject>Chloroquine</subject><subject>Chloroquine - pharmacology</subject><subject>Cytotoxicity</subject><subject>Dengue fever</subject><subject>Dengue virus</subject><subject>Dengue Virus - drug effects</subject><subject>Dengue Virus - physiology</subject><subject>Disease transmission</subject><subject>Drug Resistance</subject><subject>Electron microscopy</subject><subject>Erythrocytes</subject><subject>Fourier transforms</subject><subject>Immunology</subject><subject>Infrared spectroscopy</subject><subject>Insecticides - pharmacology</subject><subject>Larvae</subject><subject>Magnetic properties</subject><subject>Magnetite Nanoparticles - toxicity</subject><subject>Magnetospirillum gryphiswaldense</subject><subject>Malaria</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Mosquito Vectors - drug effects</subject><subject>Mosquito Vectors - physiology</subject><subject>Mosquitoes</subject><subject>Nanoparticles</subject><subject>Original Paper</subject><subject>Physiological aspects</subject><subject>Plasmodium berghei</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Plasmodium falciparum - physiology</subject><subject>Pupae</subject><subject>Toxicity</subject><subject>Transmission electron microscopy</subject><subject>Vectors</subject><subject>Vero Cells</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1v1TAQtBCIPgo_gAuyxKVITVknTuwcq1I-pBY4wNlynE2eq8R-2E5F_wE_G0evtCBR-eCVd2a8s0PISwYnDEC8jQC8agpgTVFXDAp4RDaMV2XB2rp-TDbQ5hoYqw7IsxivAJhoOH9KDkohWS2qZkN-XerRYbKGOu38TodcThipDki3dtxONzT5n7mdPDXbyQf_Y7EOi4DRxqRdol8nHWff22Wmg56MzRrLfEx7dOOC9NqGJdKjd-efi_LNMdWup2mLNtDZx6yUVa_RJB_ic_Ik0yO-uL0Pyff359_OPhYXXz58Oju9KAyXZSp4rdsODJMl7xCZBilqISpdQdPJRpbNugjAdmg7LSvokPFeykY3Unec87I6JK_3urvVCsakrvwSXP5SMSlBtHlpcI8a9YTKusGnoM1so1GndQ0tEyWwjDr5DyqfHmdrvMPB5vd_CGxPMMHHGHBQu2BnHW4UA7VGqvaRqhypWp2odZRXtwMv3Yz9HeNPhhlQ7gExt9yI4S9HD6r-BifBqrc</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Murugan, Kadarkarai</creator><creator>Wei, Jiang</creator><creator>Alsalhi, Mohamad Saleh</creator><creator>Nicoletti, Marcello</creator><creator>Paulpandi, Manickam</creator><creator>Samidoss, Christina Mary</creator><creator>Dinesh, Devakumar</creator><creator>Chandramohan, Balamurugan</creator><creator>Paneerselvam, Chellasamy</creator><creator>Subramaniam, Jayapal</creator><creator>Vadivalagan, Chithravel</creator><creator>Wei, Hui</creator><creator>Amuthavalli, Pandiyan</creator><creator>Jaganathan, Anitha</creator><creator>Devanesan, Sandhanasamy</creator><creator>Higuchi, Akon</creator><creator>Kumar, Suresh</creator><creator>Aziz, Al Thabiani</creator><creator>Nataraj, Devaraj</creator><creator>Vaseeharan, Baskaralingam</creator><creator>Canale, Angelo</creator><creator>Benelli, Giovanni</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20170201</creationdate><title>Magnetic nanoparticles are highly toxic to chloroquine-resistant Plasmodium falciparum, dengue virus (DEN-2), and their mosquito vectors</title><author>Murugan, Kadarkarai ; Wei, Jiang ; Alsalhi, Mohamad Saleh ; Nicoletti, Marcello ; Paulpandi, Manickam ; Samidoss, Christina Mary ; Dinesh, Devakumar ; Chandramohan, Balamurugan ; Paneerselvam, Chellasamy ; Subramaniam, Jayapal ; Vadivalagan, Chithravel ; Wei, Hui ; Amuthavalli, Pandiyan ; Jaganathan, Anitha ; Devanesan, Sandhanasamy ; Higuchi, Akon ; Kumar, Suresh ; Aziz, Al Thabiani ; Nataraj, Devaraj ; Vaseeharan, Baskaralingam ; Canale, Angelo ; Benelli, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-45a9b0c1824bee1a0875773a306b8682653100e9f9ba830be14d886a68ab44423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aedes - drug effects</topic><topic>Aedes - physiology</topic><topic>Aedes aegypti</topic><topic>Animals</topic><topic>Anopheles - drug effects</topic><topic>Anopheles - physiology</topic><topic>Anopheles stephensi</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cercopithecus aethiops</topic><topic>Chloroquine</topic><topic>Chloroquine - pharmacology</topic><topic>Cytotoxicity</topic><topic>Dengue fever</topic><topic>Dengue virus</topic><topic>Dengue Virus - drug effects</topic><topic>Dengue Virus - physiology</topic><topic>Disease transmission</topic><topic>Drug Resistance</topic><topic>Electron microscopy</topic><topic>Erythrocytes</topic><topic>Fourier transforms</topic><topic>Immunology</topic><topic>Infrared spectroscopy</topic><topic>Insecticides - pharmacology</topic><topic>Larvae</topic><topic>Magnetic properties</topic><topic>Magnetite Nanoparticles - toxicity</topic><topic>Magnetospirillum gryphiswaldense</topic><topic>Malaria</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Mosquito Vectors - drug effects</topic><topic>Mosquito Vectors - physiology</topic><topic>Mosquitoes</topic><topic>Nanoparticles</topic><topic>Original Paper</topic><topic>Physiological aspects</topic><topic>Plasmodium berghei</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - drug effects</topic><topic>Plasmodium falciparum - physiology</topic><topic>Pupae</topic><topic>Toxicity</topic><topic>Transmission electron microscopy</topic><topic>Vectors</topic><topic>Vero Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murugan, Kadarkarai</creatorcontrib><creatorcontrib>Wei, Jiang</creatorcontrib><creatorcontrib>Alsalhi, Mohamad Saleh</creatorcontrib><creatorcontrib>Nicoletti, Marcello</creatorcontrib><creatorcontrib>Paulpandi, Manickam</creatorcontrib><creatorcontrib>Samidoss, Christina Mary</creatorcontrib><creatorcontrib>Dinesh, Devakumar</creatorcontrib><creatorcontrib>Chandramohan, Balamurugan</creatorcontrib><creatorcontrib>Paneerselvam, Chellasamy</creatorcontrib><creatorcontrib>Subramaniam, Jayapal</creatorcontrib><creatorcontrib>Vadivalagan, Chithravel</creatorcontrib><creatorcontrib>Wei, Hui</creatorcontrib><creatorcontrib>Amuthavalli, Pandiyan</creatorcontrib><creatorcontrib>Jaganathan, Anitha</creatorcontrib><creatorcontrib>Devanesan, Sandhanasamy</creatorcontrib><creatorcontrib>Higuchi, Akon</creatorcontrib><creatorcontrib>Kumar, Suresh</creatorcontrib><creatorcontrib>Aziz, Al Thabiani</creatorcontrib><creatorcontrib>Nataraj, Devaraj</creatorcontrib><creatorcontrib>Vaseeharan, Baskaralingam</creatorcontrib><creatorcontrib>Canale, Angelo</creatorcontrib><creatorcontrib>Benelli, Giovanni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murugan, Kadarkarai</au><au>Wei, Jiang</au><au>Alsalhi, Mohamad Saleh</au><au>Nicoletti, Marcello</au><au>Paulpandi, Manickam</au><au>Samidoss, Christina Mary</au><au>Dinesh, Devakumar</au><au>Chandramohan, Balamurugan</au><au>Paneerselvam, Chellasamy</au><au>Subramaniam, Jayapal</au><au>Vadivalagan, Chithravel</au><au>Wei, Hui</au><au>Amuthavalli, Pandiyan</au><au>Jaganathan, Anitha</au><au>Devanesan, Sandhanasamy</au><au>Higuchi, Akon</au><au>Kumar, Suresh</au><au>Aziz, Al Thabiani</au><au>Nataraj, Devaraj</au><au>Vaseeharan, Baskaralingam</au><au>Canale, Angelo</au><au>Benelli, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic nanoparticles are highly toxic to chloroquine-resistant Plasmodium falciparum, dengue virus (DEN-2), and their mosquito vectors</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>116</volume><issue>2</issue><spage>495</spage><epage>502</epage><pages>495-502</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><abstract>A main challenge in parasitology is the development of reliable tools to prevent or treat mosquito-borne diseases. We investigated the toxicity of magnetic nanoparticles (MNP) produced by
Magnetospirillum gryphiswaldense
(strain MSR-1) on chloroquine-resistant (CQ-r) and sensitive (CQ-s)
Plasmodium falciparum
, dengue virus (DEN-2), and two of their main vectors,
Anopheles stephensi
and
Aedes aegypti
, respectively. MNP were studied by Fourier-transform infrared spectroscopy and transmission electron microscopy. They were toxic to larvae and pupae of
An. stephensi
, LC
50
ranged from 2.563 ppm (1st instar larva) to 6.430 ppm (pupa), and
Ae. aegypti
, LC
50
ranged from 3.231 ppm (1st instar larva) to 7.545 ppm (pupa). MNP IC
50
on
P. falciparum
were 83.32 μg ml
−1
(CQ-s) and 87.47 μg ml
−1
(CQ-r). However, the in vivo efficacy of MNP on
Plasmodium berghei
was low if compared to CQ-based treatments. Moderate cytotoxicity was detected on Vero cells post-treatment with MNP doses lower than 4 μg ml
−1
. MNP evaluated at 2–8 μg ml
−1
inhibited DEN-2 replication inhibiting the expression of the envelope (E) protein. In conclusion, our findings represent the first report about the use of MNP in medical and veterinary entomology, proposing them as suitable materials to develop reliable tools to combat mosquito-borne diseases.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27815736</pmid><doi>10.1007/s00436-016-5310-0</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0113 |
| ispartof | Parasitology research (1987), 2017-02, Vol.116 (2), p.495-502 |
| issn | 0932-0113 1432-1955 |
| language | eng |
| recordid | cdi_proquest_journals_1880790930 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aedes - drug effects Aedes - physiology Aedes aegypti Animals Anopheles - drug effects Anopheles - physiology Anopheles stephensi Biomedical and Life Sciences Biomedicine Cercopithecus aethiops Chloroquine Chloroquine - pharmacology Cytotoxicity Dengue fever Dengue virus Dengue Virus - drug effects Dengue Virus - physiology Disease transmission Drug Resistance Electron microscopy Erythrocytes Fourier transforms Immunology Infrared spectroscopy Insecticides - pharmacology Larvae Magnetic properties Magnetite Nanoparticles - toxicity Magnetospirillum gryphiswaldense Malaria Medical Microbiology Microbiology Mosquito Vectors - drug effects Mosquito Vectors - physiology Mosquitoes Nanoparticles Original Paper Physiological aspects Plasmodium berghei Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - physiology Pupae Toxicity Transmission electron microscopy Vectors Vero Cells |
| title | Magnetic nanoparticles are highly toxic to chloroquine-resistant Plasmodium falciparum, dengue virus (DEN-2), and their mosquito vectors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T17%3A20%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Magnetic%20nanoparticles%20are%20highly%20toxic%20to%20chloroquine-resistant%20Plasmodium%20falciparum,%20dengue%20virus%20(DEN-2),%20and%20their%20mosquito%20vectors&rft.jtitle=Parasitology%20research%20(1987)&rft.au=Murugan,%20Kadarkarai&rft.date=2017-02-01&rft.volume=116&rft.issue=2&rft.spage=495&rft.epage=502&rft.pages=495-502&rft.issn=0932-0113&rft.eissn=1432-1955&rft_id=info:doi/10.1007/s00436-016-5310-0&rft_dat=%3Cgale_proqu%3EA550917201%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1880790930&rft_id=info:pmid/27815736&rft_galeid=A550917201&rfr_iscdi=true |