Synthesis, antitumor evaluation, and molecular docking studies of indole–indazolyl hydrazide–hydrazone derivatives

A series of ten novel hydrazide–hydrazones linked indole and indazole moieties were designed and synthesized. All the synthesized compounds were evaluated for their cytotoxicity against four human cancer cell lines (HeLa, MDA-MB-231, MCF-7, and A549). Three of the synthesized compounds showed promis...

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Veröffentlicht in:	Monatshefte für Chemie 2017-02, Vol.148 (2), p.305-314
Hauptverfasser:	Sreenivasulu, Reddymasu, Sujitha, Pombala, Jadav, Surender Singh, Ahsan, Mohamed Jawed, Kumar, C. Ganesh, Raju, Rudraraju Ramesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Doxorubicin Hydrazones Inorganic Chemistry Molecular docking Organic Chemistry Original Paper Physical Chemistry Theoretical and Computational Chemistry Toxicity testing
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