Design and synthesis of imidazo[4,5-c]pyridine derivatives as promising Aurora kinase A (AURKA) inhibitors
Computer simulation at the PM7 level of theory of the structures of imidazo[4,5- c ]pyridine derivatives (deaza analogs of purines) and their complexes with Aurora kinase A (AURKA) indicated prospects for their use as potential AURKA inhibitors in the treatment of oncological diseases. A number of n...
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| Veröffentlicht in: | Russian journal of organic chemistry 2016-12, Vol.52 (12), p.1822-1829 |
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| container_issue | 12 |
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| container_title | Russian journal of organic chemistry |
| container_volume | 52 |
| creator | Lomov, D. A. Lyashchuk, S. N. Abramyants, M. G. |
| description | Computer simulation at the PM7 level of theory of the structures of imidazo[4,5-
c
]pyridine derivatives (deaza analogs of purines) and their complexes with Aurora kinase A (AURKA) indicated prospects for their use as potential AURKA inhibitors in the treatment of oncological diseases. A number of new compounds of the selected imidazo[4,5-
c
]pyridine series, for which the highest inhibitory activity against AURKA was predicted, were synthesized in high yields for further biological testing. |
| doi_str_mv | 10.1134/S1070428016120198 |
| format | Article |
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c
]pyridine derivatives (deaza analogs of purines) and their complexes with Aurora kinase A (AURKA) indicated prospects for their use as potential AURKA inhibitors in the treatment of oncological diseases. A number of new compounds of the selected imidazo[4,5-
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]pyridine series, for which the highest inhibitory activity against AURKA was predicted, were synthesized in high yields for further biological testing.</description><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Computer simulation</subject><subject>Derivatives</subject><subject>Inhibitors</subject><subject>Organic Chemistry</subject><subject>Purines</subject><issn>1070-4280</issn><issn>1608-3393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LAzEQxYMoWKsfwFvAi4KrM0mazR6X-hcLgtqTyJJu0jbVZmuyLdRPb0o9COJpZnjv92YYQo4RLhC5uHxGyEEwBSiRARZqh3RQgso4L_hu6pOcbfR9chDjDAAECt4hsysb3cRT7Q2Na99O0xhpM6Zu7oz-al7FeS-r3xbr4Izzlhob3Eq3bmUj1ZEuQjN30fkJLZehCZq-O6-jpSU9LYdPD-UZdX7qRq5tQjwke2P9Ee3RT-2S4c31S_8uGzze3vfLQVZzlG3GuJJSclC9XIu6x5CDzccizwUYNCaXzIyYtkoBB22lVbVQI7QFFAXmzGreJSfb3HTc59LGtpo1y-DTygoTlYKYwuTCrasOTYzBjqtFcHMd1hVCtXlp9eeliWFbJiavn9jwK_lf6Bu84XaP</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Lomov, D. A.</creator><creator>Lyashchuk, S. N.</creator><creator>Abramyants, M. G.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20161201</creationdate><title>Design and synthesis of imidazo[4,5-c]pyridine derivatives as promising Aurora kinase A (AURKA) inhibitors</title><author>Lomov, D. A. ; Lyashchuk, S. N. ; Abramyants, M. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-23866630857a4c52130e7f47740d1dd762db2ae88030ae6e8c48b1e9099172ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Computer simulation</topic><topic>Derivatives</topic><topic>Inhibitors</topic><topic>Organic Chemistry</topic><topic>Purines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lomov, D. A.</creatorcontrib><creatorcontrib>Lyashchuk, S. N.</creatorcontrib><creatorcontrib>Abramyants, M. G.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of organic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lomov, D. A.</au><au>Lyashchuk, S. N.</au><au>Abramyants, M. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design and synthesis of imidazo[4,5-c]pyridine derivatives as promising Aurora kinase A (AURKA) inhibitors</atitle><jtitle>Russian journal of organic chemistry</jtitle><stitle>Russ J Org Chem</stitle><date>2016-12-01</date><risdate>2016</risdate><volume>52</volume><issue>12</issue><spage>1822</spage><epage>1829</epage><pages>1822-1829</pages><issn>1070-4280</issn><eissn>1608-3393</eissn><abstract>Computer simulation at the PM7 level of theory of the structures of imidazo[4,5-
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| subjects | Chemistry Chemistry and Materials Science Computer simulation Derivatives Inhibitors Organic Chemistry Purines |
| title | Design and synthesis of imidazo[4,5-c]pyridine derivatives as promising Aurora kinase A (AURKA) inhibitors |
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