A New 2H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet
A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one ( 1 ), together with four known compounds, 5,6-dehydrokawain ( 2 ), dihydro-5,6-dehydrokawain ( 3 ), (E)-labda-8(17),12-diene-15,16-dial ( 4 ), and quercetin ( 5 ) were isolated from the rhizomes of Alpinia zerumbet. (E...
Gespeichert in:
| Veröffentlicht in: | Chemistry of natural compounds 2017, Vol.53 (1), p.40-43 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 43 |
|---|---|
| container_issue | 1 |
| container_start_page | 40 |
| container_title | Chemistry of natural compounds |
| container_volume | 53 |
| creator | Chen, Jih-Jung Liao, Hsiang-Ruei Chen, Keh-Shaw Cheng, Ming-Jen Shu, Chih-Wen Sung, Ping-Jyun Lim, Yun-Ping Wang, Tai-Chi Kuo, Wen-Lung |
| description | A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one (
1
), together with four known compounds, 5,6-dehydrokawain (
2
), dihydro-5,6-dehydrokawain (
3
), (E)-labda-8(17),12-diene-15,16-dial (
4
), and quercetin (
5
) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial (
4
) and quercetin (
5
) exhibited potent inhibition, with IC
50
values of 3.18 ± 1.13 and 1.17 ± 0.13 μg/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O
2
−
) generation. |
| doi_str_mv | 10.1007/s10600-017-1906-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_1880758336</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A551030891</galeid><sourcerecordid>A551030891</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-2efc608aec85c9850b8eef9c77fa2efa2d249e080e6e966ddcd92aa04154eb613</originalsourceid><addsrcrecordid>eNp1kUFrGzEQhUVoIG7SH5CboKce5Ix2vVrtcXHb2BCSkrS9Clk7axS8WlfSunF-fWQ2kBha5iBG-t4bDY-QSw5TDlBeBQ4CgAEvGa9AMHFCJrwocyZzKT-QCQBULOc5nJGPITymVgohJ-R3TW_xL80W7Mfea8cydueQfkVvdzraHVLtGlq7aJl17UZ3nY6939N570K0cUAXA-1bWm-21llNn9EP3QrjBTlt9Sbgp9fznPz6_u3nfMFu7q6X8_qGmRkvI8uwNQKkRiMLU8kCVhKxrUxZtjq96azJZhWCBBRYCdE0pqkyrWHGixmuBM_PyefRd-v7PwOGqB77wbs0UnEpoSxknos3aq03qNIiffTadDYYVRcFhxxkdfCa_oNK1WBnTe-wten-SPDlSJCYiE9xrYcQ1PLh_pjlI2t8H4LHVm297bTfKw7qkKAaE1QpQXVIUB2-nY2akFi3Rv9uuf-KXgA_a5tD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1880758336</pqid></control><display><type>article</type><title>A New 2H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet</title><source>SpringerNature Journals</source><creator>Chen, Jih-Jung ; Liao, Hsiang-Ruei ; Chen, Keh-Shaw ; Cheng, Ming-Jen ; Shu, Chih-Wen ; Sung, Ping-Jyun ; Lim, Yun-Ping ; Wang, Tai-Chi ; Kuo, Wen-Lung</creator><creatorcontrib>Chen, Jih-Jung ; Liao, Hsiang-Ruei ; Chen, Keh-Shaw ; Cheng, Ming-Jen ; Shu, Chih-Wen ; Sung, Ping-Jyun ; Lim, Yun-Ping ; Wang, Tai-Chi ; Kuo, Wen-Lung</creatorcontrib><description>A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one (
1
), together with four known compounds, 5,6-dehydrokawain (
2
), dihydro-5,6-dehydrokawain (
3
), (E)-labda-8(17),12-diene-15,16-dial (
4
), and quercetin (
5
) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial (
4
) and quercetin (
5
) exhibited potent inhibition, with IC
50
values of 3.18 ± 1.13 and 1.17 ± 0.13 μg/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O
2
−
) generation.</description><identifier>ISSN: 0009-3130</identifier><identifier>EISSN: 1573-8388</identifier><identifier>DOI: 10.1007/s10600-017-1906-6</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Anti-inflammatory agents ; Medical schools ; Medicine ; Organic Chemistry ; Pharmacy ; Phenylalanine ; Plant Sciences</subject><ispartof>Chemistry of natural compounds, 2017, Vol.53 (1), p.40-43</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-2efc608aec85c9850b8eef9c77fa2efa2d249e080e6e966ddcd92aa04154eb613</citedby><cites>FETCH-LOGICAL-c417t-2efc608aec85c9850b8eef9c77fa2efa2d249e080e6e966ddcd92aa04154eb613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10600-017-1906-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10600-017-1906-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids></links><search><creatorcontrib>Chen, Jih-Jung</creatorcontrib><creatorcontrib>Liao, Hsiang-Ruei</creatorcontrib><creatorcontrib>Chen, Keh-Shaw</creatorcontrib><creatorcontrib>Cheng, Ming-Jen</creatorcontrib><creatorcontrib>Shu, Chih-Wen</creatorcontrib><creatorcontrib>Sung, Ping-Jyun</creatorcontrib><creatorcontrib>Lim, Yun-Ping</creatorcontrib><creatorcontrib>Wang, Tai-Chi</creatorcontrib><creatorcontrib>Kuo, Wen-Lung</creatorcontrib><title>A New 2H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet</title><title>Chemistry of natural compounds</title><addtitle>Chem Nat Compd</addtitle><description>A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one (
1
), together with four known compounds, 5,6-dehydrokawain (
2
), dihydro-5,6-dehydrokawain (
3
), (E)-labda-8(17),12-diene-15,16-dial (
4
), and quercetin (
5
) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial (
4
) and quercetin (
5
) exhibited potent inhibition, with IC
50
values of 3.18 ± 1.13 and 1.17 ± 0.13 μg/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O
2
−
) generation.</description><subject>Anti-inflammatory agents</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Organic Chemistry</subject><subject>Pharmacy</subject><subject>Phenylalanine</subject><subject>Plant Sciences</subject><issn>0009-3130</issn><issn>1573-8388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kUFrGzEQhUVoIG7SH5CboKce5Ix2vVrtcXHb2BCSkrS9Clk7axS8WlfSunF-fWQ2kBha5iBG-t4bDY-QSw5TDlBeBQ4CgAEvGa9AMHFCJrwocyZzKT-QCQBULOc5nJGPITymVgohJ-R3TW_xL80W7Mfea8cydueQfkVvdzraHVLtGlq7aJl17UZ3nY6939N570K0cUAXA-1bWm-21llNn9EP3QrjBTlt9Sbgp9fznPz6_u3nfMFu7q6X8_qGmRkvI8uwNQKkRiMLU8kCVhKxrUxZtjq96azJZhWCBBRYCdE0pqkyrWHGixmuBM_PyefRd-v7PwOGqB77wbs0UnEpoSxknos3aq03qNIiffTadDYYVRcFhxxkdfCa_oNK1WBnTe-wten-SPDlSJCYiE9xrYcQ1PLh_pjlI2t8H4LHVm297bTfKw7qkKAaE1QpQXVIUB2-nY2akFi3Rv9uuf-KXgA_a5tD</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Chen, Jih-Jung</creator><creator>Liao, Hsiang-Ruei</creator><creator>Chen, Keh-Shaw</creator><creator>Cheng, Ming-Jen</creator><creator>Shu, Chih-Wen</creator><creator>Sung, Ping-Jyun</creator><creator>Lim, Yun-Ping</creator><creator>Wang, Tai-Chi</creator><creator>Kuo, Wen-Lung</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>2017</creationdate><title>A New 2H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet</title><author>Chen, Jih-Jung ; Liao, Hsiang-Ruei ; Chen, Keh-Shaw ; Cheng, Ming-Jen ; Shu, Chih-Wen ; Sung, Ping-Jyun ; Lim, Yun-Ping ; Wang, Tai-Chi ; Kuo, Wen-Lung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2efc608aec85c9850b8eef9c77fa2efa2d249e080e6e966ddcd92aa04154eb613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Anti-inflammatory agents</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Organic Chemistry</topic><topic>Pharmacy</topic><topic>Phenylalanine</topic><topic>Plant Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jih-Jung</creatorcontrib><creatorcontrib>Liao, Hsiang-Ruei</creatorcontrib><creatorcontrib>Chen, Keh-Shaw</creatorcontrib><creatorcontrib>Cheng, Ming-Jen</creatorcontrib><creatorcontrib>Shu, Chih-Wen</creatorcontrib><creatorcontrib>Sung, Ping-Jyun</creatorcontrib><creatorcontrib>Lim, Yun-Ping</creatorcontrib><creatorcontrib>Wang, Tai-Chi</creatorcontrib><creatorcontrib>Kuo, Wen-Lung</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Chemistry of natural compounds</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jih-Jung</au><au>Liao, Hsiang-Ruei</au><au>Chen, Keh-Shaw</au><au>Cheng, Ming-Jen</au><au>Shu, Chih-Wen</au><au>Sung, Ping-Jyun</au><au>Lim, Yun-Ping</au><au>Wang, Tai-Chi</au><au>Kuo, Wen-Lung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A New 2H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet</atitle><jtitle>Chemistry of natural compounds</jtitle><stitle>Chem Nat Compd</stitle><date>2017</date><risdate>2017</risdate><volume>53</volume><issue>1</issue><spage>40</spage><epage>43</epage><pages>40-43</pages><issn>0009-3130</issn><eissn>1573-8388</eissn><abstract>A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one (
1
), together with four known compounds, 5,6-dehydrokawain (
2
), dihydro-5,6-dehydrokawain (
3
), (E)-labda-8(17),12-diene-15,16-dial (
4
), and quercetin (
5
) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial (
4
) and quercetin (
5
) exhibited potent inhibition, with IC
50
values of 3.18 ± 1.13 and 1.17 ± 0.13 μg/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O
2
−
) generation.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10600-017-1906-6</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-3130 |
| ispartof | Chemistry of natural compounds, 2017, Vol.53 (1), p.40-43 |
| issn | 0009-3130 1573-8388 |
| language | eng |
| recordid | cdi_proquest_journals_1880758336 |
| source | SpringerNature Journals |
| subjects | Anti-inflammatory agents Medical schools Medicine Organic Chemistry Pharmacy Phenylalanine Plant Sciences |
| title | A New 2H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T07%3A32%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20New%202H-Pyran-2-One%20Derivative%20and%20Anti-inflammatory%20Constituents%20of%20Alpinia%20zerumbet&rft.jtitle=Chemistry%20of%20natural%20compounds&rft.au=Chen,%20Jih-Jung&rft.date=2017&rft.volume=53&rft.issue=1&rft.spage=40&rft.epage=43&rft.pages=40-43&rft.issn=0009-3130&rft.eissn=1573-8388&rft_id=info:doi/10.1007/s10600-017-1906-6&rft_dat=%3Cgale_proqu%3EA551030891%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1880758336&rft_id=info:pmid/&rft_galeid=A551030891&rfr_iscdi=true |