Synthesis, characterization, and antimicrobial activity of some chiral linear carboxamides with incorporated peptide linkage

A new group of chiral linear 7-methyl-4-oxo-1,8-naphthyridine-3-carboxamides with incorporated peptide linkage have been synthesized via condensation of 1-ethyl- N -(1-hydrazinyl-3-methyl-1-oxobutan-2-yl)-7-methyl–4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide with various derivatives of sugar pe...

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Veröffentlicht in:	Russian journal of general chemistry 2016-12, Vol.86 (12), p.2785-2790
Hauptverfasser:	Khalifa, N. M., Amr, A. E. G., Al-Omar, M. A., Nossier, E. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical analysis Chemical compounds Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Condensates Pentose
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Zusammenfassung:	A new group of chiral linear 7-methyl-4-oxo-1,8-naphthyridine-3-carboxamides with incorporated peptide linkage have been synthesized via condensation of 1-ethyl- N -(1-hydrazinyl-3-methyl-1-oxobutan-2-yl)-7-methyl–4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide with various derivatives of sugar pentose, acetophenones and thiosemicarbazide. Structures of the products were elucidated by spectroscopic methods and chemical analysis. Antimicrobial properties of the synthesized compounds were tested.
ISSN:	1070-3632 1608-3350
DOI:	10.1134/S1070363216120409