Synthesis of new 1,3-thiazole derivatives from 2(5)-hydroxyalkyl-1,3-thiazole-5(2)-carbaldehydes

Synthesis of new 1,3-thiazole derivatives from 2(5)-hydroxyalkyl-1,3-thiazole-5(2)-carbaldehydes

Reactions of substituted 2-hydroxyalkyl-1,3-thiazole-5-carbaldehydes and 5-hydroxyalkyl-1,3-thiazole-2-carbaldehydes with phenylhydrazine, isoniazid, N-substituted rhodanines were performed as well as Biginelli reaction with acetoacetic ester and urea. As a result, new 1,3-thiazole derivatives were...

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Veröffentlicht in:Russian journal of general chemistry 2016-07, Vol.86 (7), p.1597-1603
Hauptverfasser: Sinenko, V. O., Slivchuk, S. R., Pil’o, S. G., Raenko, G. F., Brovarets, V. S.
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Biocompatibility
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
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container_end_page 1603
container_issue 7
container_start_page 1597
container_title Russian journal of general chemistry
container_volume 86
creator Sinenko, V. O.
Slivchuk, S. R.
Pil’o, S. G.
Raenko, G. F.
Brovarets, V. S.
description Reactions of substituted 2-hydroxyalkyl-1,3-thiazole-5-carbaldehydes and 5-hydroxyalkyl-1,3-thiazole-2-carbaldehydes with phenylhydrazine, isoniazid, N-substituted rhodanines were performed as well as Biginelli reaction with acetoacetic ester and urea. As a result, new 1,3-thiazole derivatives were obtained. They are of interest as potential bioactive substances.
doi_str_mv 10.1134/S1070363216070100
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subjects Biocompatibility
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
title Synthesis of new 1,3-thiazole derivatives from 2(5)-hydroxyalkyl-1,3-thiazole-5(2)-carbaldehydes
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