13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

13- cis -Retinoic acid has been reported to be effective in treating oral leukoplakia. We randomly assigned 44 patients with this disease to receive 13- cis -retinoic acid (24 patients) or placebo (20), 1 to 2 mg per kilogram of body weight per day for three months, and followed them for six months....

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Veröffentlicht in:	The New England journal of medicine 1986-12, Vol.315 (24), p.1501-1505
Hauptverfasser:	Hong, Waun Ki, Endicott, James, Itri, Loretta M, Doos, Wilhelm, Batsakis, John G, Bell, Richard, Fofonoff, Stephanie, Byers, Robert, Atkinson, E. Neely, Vaughan, Charles, Toth, Bela B, Kramer, Alan, Dimery, Isaiah W, Skipper, Paulette, Strong, Stuart
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aged Biological and medical sciences Body weight Clinical Trials as Topic Conjunctivitis Dysplasia Erythema Female Hospitals Humans Hypertriglyceridemia Isotretinoin Laboratories Leukokeratosis Leukoplakia, Oral - drug therapy Leukoplakia, Oral - pathology Male Medical sciences Middle Aged Oncology Oral cancer Otolaryngology Patients Pharmacology. Drug treatments Random Allocation Retinoic acid Rodents Skin Skin, nail, hair, dermoskeleton Toxicity Tretinoin - administration & dosage Tretinoin - adverse effects Tretinoin - therapeutic use Vitamin A
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