CALCIUM-DEPENDENT SECRETORY RESPONSE OF ISOLATED RAT PANCREAS TO THE VENOM OF THE SYDNEY FUNNEL-WEB SPIDER (ATRAX ROBUSTUS)

CALCIUM-DEPENDENT SECRETORY RESPONSE OF ISOLATED RAT PANCREAS TO THE VENOM OF THE SYDNEY FUNNEL-WEB SPIDER (ATRAX ROBUSTUS)

The effects of the venom of the male Sydney funnel-Web spider (Atrax robustus) on pancreatic exocrine secretion were studied in an isolated rat pancreas preparation perfused with modified Krebs-Henseleit solution. The venom increased pancreatic juice flow and protein concentration. The protein outpu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biomedical Research 1987/04/01, Vol.8(2), pp.89-93
Hauptverfasser: NEVALAINEN, TIMO J., KANNNO, TOMIO, INOOKA, GEN, SUTHERLAND, STRUAN K.
Format: Artikel
Sprache:eng
Schlagworte:
Atrax robustus
Calcium
Calcium (extracellular)
Glands
Pancreas
Rodents
Secretion
Spiders
Venom
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The effects of the venom of the male Sydney funnel-Web spider (Atrax robustus) on pancreatic exocrine secretion were studied in an isolated rat pancreas preparation perfused with modified Krebs-Henseleit solution. The venom increased pancreatic juice flow and protein concentration. The protein output depended on the presence of extracellular Ca2+ ion and was dose-dependent over a wide venom concentration (6 ng/ml-10 μg/ml). No ultrastructural changes were seen in the venom-treated glands. The mechanism of the stimulatory effect of the venom remains to be elucidated.
ISSN:0388-6107
1880-313X
DOI:10.2220/biomedres.8.89