RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1[alpha] mRNA is translated

YTH domain containing 2 (YTHDC2) is a member of the DExD/H-box family of ATP-dependent RNA helicases. We previously found thatYTHDC2expression is up-regulated in several human cancer cells. In this study, we demonstrate novel roles for YTHDC2 in metastasis of colon tumor cells via translation-depend...

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Veröffentlicht in:	Cancer letters 2016-06, Vol.376 (1), p.34
Hauptverfasser:	Tanabe, Atsushi, Tanikawa, Kenya, Tsunetomi, Mai, Takai, Kaori, Ikeda, Hiroto, Konno, Junpei, Torigoe, Toshihiko, Maeda, Hideki, Kutomi, Goro, Okita, Kenji, Mori, Mitsuru, Sahara, Hiroeki
Format:	Artikel
Sprache:	eng
Schlagworte:	Cloning Colorectal cancer Deoxyribonucleic acid DNA Efficiency Gene expression Genomes Hypoxia Metastasis Plasmids Proteins Rodents Science Studies Transcription factors Tumor necrosis factor-TNF Tumorigenesis
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