MicroRNA-15b silencing inhibits IL-1[beta]-induced extracellular matrix degradation by targeting SMAD3 in human nucleus pulposus cells

Objectives To determine the role of microRNA-15b (miR-15b) in interleukin-1 beta (IL-1[beta])-induced extracellular matrix (ECM) degradation in the nucleus pulposus (NP). Results MiR-15b was up-regulated in degenerative NP tissues and in IL-1[beta]-stimulated NP cells, as compared to the levels in n...

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Veröffentlicht in:	Biotechnology letters 2017-04, Vol.39 (4), p.623
Hauptverfasser:	Kang, Liang, Yang, Cao, Yin, Huipeng, Zhao, Kangcheng, Liu, Wei, Hua, Wenbin, Wang, Kun, Song, Yu, Tu, Ji, Li, Shuai, Luo, Rongjin, Zhang, Yukun
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Cellular biology Extracellular matrix Genetics Ribonucleic acid RNA Scoliosis Vertebrae
Online-Zugang:	Volltext
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