Protective role of quercetin against hematotoxic and immunotoxic effects of furan in rats
Furan (Fu) is a liver carcinogen produced during heating process of food and concerns a public health problem. The current study was undertaken to evaluate the protective role of quercetin (Que) on Fu-induced hematological, immunological, and histopathological alterations in rats. Fifty male Sprague...
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| description | Furan (Fu) is a liver carcinogen produced during heating process of food and concerns a public health problem. The current study was undertaken to evaluate the protective role of quercetin (Que) on Fu-induced hematological, immunological, and histopathological alterations in rats. Fifty male Sprague Dawley rats were divided into five equal groups. Group I (Cont) received distilled water, group II (CO) received corn oil, group III (Que) received Que at 50 mg/kg BW, group IV (Fu) received Fu at 16 mg/kg BW, and group V received Que + Fu simultaneously; all groups gavaged daily for 30 days. Our results revealed that Fu administration significantly elevated RBCs, Hb, PCV, WBCs, lymphocytes, and granulocytes and reduced phagocytic percent (Ph%) and index (PhI). Fu decreased the serum total protein, albumin, globulin, IgM, IgG, and IL4, with a significant increase in the TNFα and 8-OHdG. Moreover, it decreased the GSH content and GST activity and increased the MDA levels in the splenic tissue. Histopathologically, Fu led to a moderate depletion in the lymphoid cells and weak immunostaining of CD20 antigen of few lymphocytes appeared in the spleen. Meanwhile, Que co-administration ameliorated the altered hematological parameters and improved the Ph% and PhI. It modulated the serum biochemical parameters and immunoglobulins. Moreover, it decreased lipid peroxidation and enhanced antioxidant status in the spleen. The results indicated that Que possesses antioxidant protective activity against Fu-induced oxidative damage and stimulates the immune function. |
| doi_str_mv | 10.1007/s11356-016-8108-9 |
| format | Article |
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Abu ; Imam, Tamer S.</creator><creatorcontrib>Alam, Rasha T. ; Zeid, Ehsan H. Abu ; Imam, Tamer S.</creatorcontrib><description>Furan (Fu) is a liver carcinogen produced during heating process of food and concerns a public health problem. The current study was undertaken to evaluate the protective role of quercetin (Que) on Fu-induced hematological, immunological, and histopathological alterations in rats. Fifty male Sprague Dawley rats were divided into five equal groups. Group I (Cont) received distilled water, group II (CO) received corn oil, group III (Que) received Que at 50 mg/kg BW, group IV (Fu) received Fu at 16 mg/kg BW, and group V received Que + Fu simultaneously; all groups gavaged daily for 30 days. Our results revealed that Fu administration significantly elevated RBCs, Hb, PCV, WBCs, lymphocytes, and granulocytes and reduced phagocytic percent (Ph%) and index (PhI). Fu decreased the serum total protein, albumin, globulin, IgM, IgG, and IL4, with a significant increase in the TNFα and 8-OHdG. Moreover, it decreased the GSH content and GST activity and increased the MDA levels in the splenic tissue. Histopathologically, Fu led to a moderate depletion in the lymphoid cells and weak immunostaining of CD20 antigen of few lymphocytes appeared in the spleen. Meanwhile, Que co-administration ameliorated the altered hematological parameters and improved the Ph% and PhI. It modulated the serum biochemical parameters and immunoglobulins. Moreover, it decreased lipid peroxidation and enhanced antioxidant status in the spleen. The results indicated that Que possesses antioxidant protective activity against Fu-induced oxidative damage and stimulates the immune function.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-016-8108-9</identifier><identifier>PMID: 27889890</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Antioxidants ; Antioxidants - metabolism ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Carcinogens ; Chemical compounds ; Distilled water ; DNA damage ; Drug dosages ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Experiments ; Furans - toxicity ; Granulocytes ; Hematology ; Immune response ; Immunoglobulins ; Laboratory animals ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Lymphocytes ; Male ; Medical research ; Oils & fats ; Oxidative Stress - drug effects ; Peroxidation ; Proteins ; Public health ; Quercetin - pharmacology ; Rats ; Rats, Sprague-Dawley ; Research Article ; Rodents ; Spleen ; Studies ; Tumor necrosis factor-TNF ; Veterinary medicine ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2017-02, Vol.24 (4), p.3780-3789</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Environmental Science and Pollution Research is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-50269b5e0725d9e48d128b44659f8785ab199d3d5807d791e6681d0b2c35271b3</citedby><cites>FETCH-LOGICAL-c372t-50269b5e0725d9e48d128b44659f8785ab199d3d5807d791e6681d0b2c35271b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-016-8108-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-016-8108-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27889890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alam, Rasha T.</creatorcontrib><creatorcontrib>Zeid, Ehsan H. Abu</creatorcontrib><creatorcontrib>Imam, Tamer S.</creatorcontrib><title>Protective role of quercetin against hematotoxic and immunotoxic effects of furan in rats</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Furan (Fu) is a liver carcinogen produced during heating process of food and concerns a public health problem. The current study was undertaken to evaluate the protective role of quercetin (Que) on Fu-induced hematological, immunological, and histopathological alterations in rats. Fifty male Sprague Dawley rats were divided into five equal groups. Group I (Cont) received distilled water, group II (CO) received corn oil, group III (Que) received Que at 50 mg/kg BW, group IV (Fu) received Fu at 16 mg/kg BW, and group V received Que + Fu simultaneously; all groups gavaged daily for 30 days. Our results revealed that Fu administration significantly elevated RBCs, Hb, PCV, WBCs, lymphocytes, and granulocytes and reduced phagocytic percent (Ph%) and index (PhI). Fu decreased the serum total protein, albumin, globulin, IgM, IgG, and IL4, with a significant increase in the TNFα and 8-OHdG. Moreover, it decreased the GSH content and GST activity and increased the MDA levels in the splenic tissue. Histopathologically, Fu led to a moderate depletion in the lymphoid cells and weak immunostaining of CD20 antigen of few lymphocytes appeared in the spleen. Meanwhile, Que co-administration ameliorated the altered hematological parameters and improved the Ph% and PhI. It modulated the serum biochemical parameters and immunoglobulins. Moreover, it decreased lipid peroxidation and enhanced antioxidant status in the spleen. The results indicated that Que possesses antioxidant protective activity against Fu-induced oxidative damage and stimulates the immune function.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Carcinogens</subject><subject>Chemical compounds</subject><subject>Distilled water</subject><subject>DNA damage</subject><subject>Drug dosages</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Experiments</subject><subject>Furans - toxicity</subject><subject>Granulocytes</subject><subject>Hematology</subject><subject>Immune response</subject><subject>Immunoglobulins</subject><subject>Laboratory animals</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical research</subject><subject>Oils & fats</subject><subject>Oxidative Stress - drug effects</subject><subject>Peroxidation</subject><subject>Proteins</subject><subject>Public health</subject><subject>Quercetin - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research Article</subject><subject>Rodents</subject><subject>Spleen</subject><subject>Studies</subject><subject>Tumor necrosis factor-TNF</subject><subject>Veterinary medicine</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LAzEURYMotlZ_gBsJuB7Ny-RzKeIXFHShC1chM8nUKZ2ZmmRE_70preLG1SO8c-4LF6FTIBdAiLyMACUXBQFRKCCq0HtoCgJYIZnW-2hKNGMFlIxN0FGMS0Io0VQeogmVSmmlyRS9PoUh-Tq1Hx6HYeXx0OD30Yfap7bHdmHbPib85jubhjR8tjW2vcNt14397u2bJvtxIzZjsD3OXrApHqODxq6iP9nNGXq5vXm-vi_mj3cP11fzoi4lTQUnVOiKeyIpd9oz5YCqijHBdaOk4rYCrV3puCLSSQ1eCAWOVLQuOZVQlTN0vs1dhyH_PCazHMbQ55MGlMy0VFpkCrZUHYYYg2_MOrSdDV8GiNmUabZlmlym2ZRpdHbOdslj1Xn3a_y0lwG6BWJe9Qsf_pz-N_UbO5h-2w</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Alam, Rasha T.</creator><creator>Zeid, Ehsan H. 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Abu</au><au>Imam, Tamer S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective role of quercetin against hematotoxic and immunotoxic effects of furan in rats</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>24</volume><issue>4</issue><spage>3780</spage><epage>3789</epage><pages>3780-3789</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Furan (Fu) is a liver carcinogen produced during heating process of food and concerns a public health problem. The current study was undertaken to evaluate the protective role of quercetin (Que) on Fu-induced hematological, immunological, and histopathological alterations in rats. Fifty male Sprague Dawley rats were divided into five equal groups. Group I (Cont) received distilled water, group II (CO) received corn oil, group III (Que) received Que at 50 mg/kg BW, group IV (Fu) received Fu at 16 mg/kg BW, and group V received Que + Fu simultaneously; all groups gavaged daily for 30 days. Our results revealed that Fu administration significantly elevated RBCs, Hb, PCV, WBCs, lymphocytes, and granulocytes and reduced phagocytic percent (Ph%) and index (PhI). Fu decreased the serum total protein, albumin, globulin, IgM, IgG, and IL4, with a significant increase in the TNFα and 8-OHdG. Moreover, it decreased the GSH content and GST activity and increased the MDA levels in the splenic tissue. Histopathologically, Fu led to a moderate depletion in the lymphoid cells and weak immunostaining of CD20 antigen of few lymphocytes appeared in the spleen. Meanwhile, Que co-administration ameliorated the altered hematological parameters and improved the Ph% and PhI. It modulated the serum biochemical parameters and immunoglobulins. Moreover, it decreased lipid peroxidation and enhanced antioxidant status in the spleen. The results indicated that Que possesses antioxidant protective activity against Fu-induced oxidative damage and stimulates the immune function.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27889890</pmid><doi>10.1007/s11356-016-8108-9</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Antioxidants Antioxidants - metabolism Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Carcinogens Chemical compounds Distilled water DNA damage Drug dosages Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Experiments Furans - toxicity Granulocytes Hematology Immune response Immunoglobulins Laboratory animals Lipid peroxidation Lipid Peroxidation - drug effects Lymphocytes Male Medical research Oils & fats Oxidative Stress - drug effects Peroxidation Proteins Public health Quercetin - pharmacology Rats Rats, Sprague-Dawley Research Article Rodents Spleen Studies Tumor necrosis factor-TNF Veterinary medicine Waste Water Technology Water Management Water Pollution Control |
| title | Protective role of quercetin against hematotoxic and immunotoxic effects of furan in rats |
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