Des-[gamma]-Carboxy (Abnormal) Prothrombin as a Serum Marker of Primary Hepatocellular Carcinoma

Abstract We detected des-γ-carboxy prothrombin, an abnormal prothrombin, in the serum of 69 of 76 patients (91 per cent) with biopsy-confirmed hepatocellular carcinoma (the mean level of the abnormal prothrombin was 900 ng per milliliter). In contrast, levels of the abnormal prothrombin were low in...

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