Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol
The effects of 10 hormone preparations (having various estrogen/progestin potencies) on plasma levels of lipid and lipoprotein cholesterol were evaluated in a study of 374 women taking oral contraceptives (OC), 284 women taking estrogens after menopause, and 1086 women taking no hormones (control gr...
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| Veröffentlicht in: | The New England journal of medicine 1983-04, Vol.308 (15), p.862-867 |
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| container_title | The New England journal of medicine |
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| creator | Wahl, Patricia Walden, Carolyn Knopp, Robert Hoover, Joanne Wallace, Robert Heiss, Gerardo Rifkind, Basil |
| description | The effects of 10 hormone preparations (having various estrogen/progestin potencies) on plasma levels of lipid and lipoprotein cholesterol were evaluated in a study of 374 women taking oral contraceptives (OC), 284 women taking estrogens after menopause, and 1086 women taking no hormones (control group). Premenopausal women taking oral contraceptives containing a low estrogen and medium-to-high progestin level had 24% higher median low-density-lipoprotein (LDL) cholesterol and lower high-density lipoprotein (HDL) cholesterol levels than the controls; women taking OC containing a high estrogen and low progestin level had higher HDL cholesterol level than controls. The use of estrogen in postmenopausal women was associated with levels of LDL cholesterol that were 11-19% below the control postmenopausal women. The effects of estrogen-progestin balance on low-density and high-density lipoproteins may be associated with increased stroke and myocardial infarction incidence in women of child-bearing age taking OC. (wz) |
| doi_str_mv | 10.1056/NEJM198304143081502 |
| format | Article |
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Premenopausal women taking oral contraceptives containing a low estrogen and medium-to-high progestin level had 24% higher median low-density-lipoprotein (LDL) cholesterol and lower high-density lipoprotein (HDL) cholesterol levels than the controls; women taking OC containing a high estrogen and low progestin level had higher HDL cholesterol level than controls. The use of estrogen in postmenopausal women was associated with levels of LDL cholesterol that were 11-19% below the control postmenopausal women. The effects of estrogen-progestin balance on low-density and high-density lipoproteins may be associated with increased stroke and myocardial infarction incidence in women of child-bearing age taking OC. (wz)</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198304143081502</identifier><identifier>PMID: 6572785</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject><![CDATA[Adult ; adults ; Age Factors ; cardiovascular diseases ; cholesterol ; Cholesterol - blood ; Cholesterol, HDL ; Cholesterol, LDL ; Cholesterol, VLDL ; Contraceptives, oral ; Contraceptives, Oral, Sequential - adverse effects ; Contraceptives, Oral, Synthetic - adverse effects ; Drug Combinations ; Estrogens ; Estrogens - administration & dosage ; Estrogens - adverse effects ; Ethinyl Estradiol - administration & dosage ; Ethinyl Estradiol - adverse effects ; Female ; females ; Health risk assessment ; Hormones ; Humans ; Lipids ; Lipids - blood ; lipoproteins ; Lipoproteins - blood ; Lipoproteins, HDL - blood ; Lipoproteins, LDL - blood ; Lipoproteins, VLDL - blood ; Low density lipoprotein ; Mestranol - administration & dosage ; Mestranol - adverse effects ; Middle Aged ; Norethindrone - administration & dosage ; Norethindrone - adverse effects ; Norgestrel - administration & dosage ; Norgestrel - adverse effects ; Progestins - administration & dosage ; Progestins - adverse effects ; risk factors ; Triglycerides - blood ; Womens health]]></subject><ispartof>The New England journal of medicine, 1983-04, Vol.308 (15), p.862-867</ispartof><rights>Copyright Massachusetts Medical Society Apr 14, 1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-82333ee8efd1eef1bfd28887c0ac1d174dbf2c8c978ab77f5c9dfba84da85a483</citedby><cites>FETCH-LOGICAL-c500t-82333ee8efd1eef1bfd28887c0ac1d174dbf2c8c978ab77f5c9dfba84da85a483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1875184799?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,64384,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6572785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wahl, Patricia</creatorcontrib><creatorcontrib>Walden, Carolyn</creatorcontrib><creatorcontrib>Knopp, Robert</creatorcontrib><creatorcontrib>Hoover, Joanne</creatorcontrib><creatorcontrib>Wallace, Robert</creatorcontrib><creatorcontrib>Heiss, Gerardo</creatorcontrib><creatorcontrib>Rifkind, Basil</creatorcontrib><title>Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>The effects of 10 hormone preparations (having various estrogen/progestin potencies) on plasma levels of lipid and lipoprotein cholesterol were evaluated in a study of 374 women taking oral contraceptives (OC), 284 women taking estrogens after menopause, and 1086 women taking no hormones (control group). Premenopausal women taking oral contraceptives containing a low estrogen and medium-to-high progestin level had 24% higher median low-density-lipoprotein (LDL) cholesterol and lower high-density lipoprotein (HDL) cholesterol levels than the controls; women taking OC containing a high estrogen and low progestin level had higher HDL cholesterol level than controls. The use of estrogen in postmenopausal women was associated with levels of LDL cholesterol that were 11-19% below the control postmenopausal women. The effects of estrogen-progestin balance on low-density and high-density lipoproteins may be associated with increased stroke and myocardial infarction incidence in women of child-bearing age taking OC. (wz)</description><subject>Adult</subject><subject>adults</subject><subject>Age Factors</subject><subject>cardiovascular diseases</subject><subject>cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL</subject><subject>Cholesterol, LDL</subject><subject>Cholesterol, VLDL</subject><subject>Contraceptives, oral</subject><subject>Contraceptives, Oral, Sequential - adverse effects</subject><subject>Contraceptives, Oral, Synthetic - adverse effects</subject><subject>Drug Combinations</subject><subject>Estrogens</subject><subject>Estrogens - administration & dosage</subject><subject>Estrogens - adverse effects</subject><subject>Ethinyl Estradiol - administration & dosage</subject><subject>Ethinyl Estradiol - adverse effects</subject><subject>Female</subject><subject>females</subject><subject>Health risk assessment</subject><subject>Hormones</subject><subject>Humans</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>lipoproteins</subject><subject>Lipoproteins - blood</subject><subject>Lipoproteins, HDL - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Lipoproteins, VLDL - blood</subject><subject>Low density lipoprotein</subject><subject>Mestranol - administration & dosage</subject><subject>Mestranol - adverse effects</subject><subject>Middle Aged</subject><subject>Norethindrone - administration & dosage</subject><subject>Norethindrone - adverse effects</subject><subject>Norgestrel - administration & dosage</subject><subject>Norgestrel - adverse effects</subject><subject>Progestins - administration & dosage</subject><subject>Progestins - adverse effects</subject><subject>risk factors</subject><subject>Triglycerides - blood</subject><subject>Womens health</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFUMtOwzAQtBColMIXIEQkjijUju16c0RVeKnAAXq2HMcuqZK42Omhf4-rVJyQ2MPuYWZndgehS4LvCOaz6Vvx8kpyoJgRRjEQjrMjNCac0pQxPDtGY4wzSJnI6Sk6C2GNYxGWj9BoxkUmgI9RUVhrdJ84m5jQe7cy3XSzH6Gvu2TjetPpXeK6pKk3dTWN3UW4NxHUX66JNONdc45OrGqCuTjMCVo-FJ_zp3Tx_vg8v1-kmmPcp5BRSo0BYytijCWlrTIAEBorTSoiWFXaTIPOBahSCMt1XtlSAasUcMWATtDNoBtv-N5Gc7l2W99FS0lAcALx1zyy6MDS3oXgjZUbX7fK7yTBcp-c_CO5uHV10N6Wral-dw5RRfx2wNs2yM6s23_Urge2VU6qla-DXH5kmFCckZwC5_QHrNR_ew</recordid><startdate>19830414</startdate><enddate>19830414</enddate><creator>Wahl, Patricia</creator><creator>Walden, Carolyn</creator><creator>Knopp, Robert</creator><creator>Hoover, Joanne</creator><creator>Wallace, Robert</creator><creator>Heiss, Gerardo</creator><creator>Rifkind, Basil</creator><general>Massachusetts Medical Society</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19830414</creationdate><title>Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol</title><author>Wahl, Patricia ; Walden, Carolyn ; Knopp, Robert ; Hoover, Joanne ; Wallace, Robert ; Heiss, Gerardo ; Rifkind, Basil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-82333ee8efd1eef1bfd28887c0ac1d174dbf2c8c978ab77f5c9dfba84da85a483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>adults</topic><topic>Age Factors</topic><topic>cardiovascular diseases</topic><topic>cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL</topic><topic>Cholesterol, LDL</topic><topic>Cholesterol, VLDL</topic><topic>Contraceptives, oral</topic><topic>Contraceptives, Oral, Sequential - adverse effects</topic><topic>Contraceptives, Oral, Synthetic - adverse effects</topic><topic>Drug Combinations</topic><topic>Estrogens</topic><topic>Estrogens - administration & dosage</topic><topic>Estrogens - adverse effects</topic><topic>Ethinyl Estradiol - administration & dosage</topic><topic>Ethinyl Estradiol - adverse effects</topic><topic>Female</topic><topic>females</topic><topic>Health risk assessment</topic><topic>Hormones</topic><topic>Humans</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>lipoproteins</topic><topic>Lipoproteins - blood</topic><topic>Lipoproteins, HDL - blood</topic><topic>Lipoproteins, LDL - blood</topic><topic>Lipoproteins, VLDL - blood</topic><topic>Low density lipoprotein</topic><topic>Mestranol - administration & dosage</topic><topic>Mestranol - adverse effects</topic><topic>Middle Aged</topic><topic>Norethindrone - administration & dosage</topic><topic>Norethindrone - adverse effects</topic><topic>Norgestrel - administration & dosage</topic><topic>Norgestrel - adverse effects</topic><topic>Progestins - administration & dosage</topic><topic>Progestins - adverse effects</topic><topic>risk factors</topic><topic>Triglycerides - blood</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wahl, Patricia</creatorcontrib><creatorcontrib>Walden, Carolyn</creatorcontrib><creatorcontrib>Knopp, Robert</creatorcontrib><creatorcontrib>Hoover, Joanne</creatorcontrib><creatorcontrib>Wallace, Robert</creatorcontrib><creatorcontrib>Heiss, Gerardo</creatorcontrib><creatorcontrib>Rifkind, Basil</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>ProQuest - 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Premenopausal women taking oral contraceptives containing a low estrogen and medium-to-high progestin level had 24% higher median low-density-lipoprotein (LDL) cholesterol and lower high-density lipoprotein (HDL) cholesterol levels than the controls; women taking OC containing a high estrogen and low progestin level had higher HDL cholesterol level than controls. The use of estrogen in postmenopausal women was associated with levels of LDL cholesterol that were 11-19% below the control postmenopausal women. The effects of estrogen-progestin balance on low-density and high-density lipoproteins may be associated with increased stroke and myocardial infarction incidence in women of child-bearing age taking OC. (wz)</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>6572785</pmid><doi>10.1056/NEJM198304143081502</doi><tpages>6</tpages></addata></record> |
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| ispartof | The New England journal of medicine, 1983-04, Vol.308 (15), p.862-867 |
| issn | 0028-4793 1533-4406 |
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| subjects | Adult adults Age Factors cardiovascular diseases cholesterol Cholesterol - blood Cholesterol, HDL Cholesterol, LDL Cholesterol, VLDL Contraceptives, oral Contraceptives, Oral, Sequential - adverse effects Contraceptives, Oral, Synthetic - adverse effects Drug Combinations Estrogens Estrogens - administration & dosage Estrogens - adverse effects Ethinyl Estradiol - administration & dosage Ethinyl Estradiol - adverse effects Female females Health risk assessment Hormones Humans Lipids Lipids - blood lipoproteins Lipoproteins - blood Lipoproteins, HDL - blood Lipoproteins, LDL - blood Lipoproteins, VLDL - blood Low density lipoprotein Mestranol - administration & dosage Mestranol - adverse effects Middle Aged Norethindrone - administration & dosage Norethindrone - adverse effects Norgestrel - administration & dosage Norgestrel - adverse effects Progestins - administration & dosage Progestins - adverse effects risk factors Triglycerides - blood Womens health |
| title | Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol |
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