Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland
Development of the salivary gland is characterized by extensive branching morphogenesis and lumen formation as well as differentiation into acinar and ductal cells. Although various molecules have been implicated in salivary gland development, transcription factors regulating the expression of those...
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| Veröffentlicht in: | Journal of Oral Tissue Engineering 2016, Vol.14(2), pp.98-106 |
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| container_title | Journal of Oral Tissue Engineering |
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| creator | MATSUSHITA, Takumi SAKAI, Takayoshi YOSHIDA, Hiroaki MORITA, Shosuke |
| description | Development of the salivary gland is characterized by extensive branching morphogenesis and lumen formation as well as differentiation into acinar and ductal cells. Although various molecules have been implicated in salivary gland development, transcription factors regulating the expression of those molecules and salivary gland development are largely unknown. The GRHL2 transcription factor and its target gene product SPINT1 as well as the SPINT1-regualted protease matriptase play crucial roles in epithelial development in several organs. Here we examined the expression of these epithelial regulators in developing mouse SMG. Of the three Grhl gene members, Grhl2 was the most abundant in embryonic SMG. The expression levels of GRHL2, SPINT1 and matriptase were increased during development of the gland. All of these molecules were expressed exclusively in the epithelial tissue. The present data may suggest the involvement of these molecules in SMG development and give a clue to developing a regenerative therapy of damaged salivary glands. |
| doi_str_mv | 10.11223/jarde.14.98 |
| format | Article |
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Although various molecules have been implicated in salivary gland development, transcription factors regulating the expression of those molecules and salivary gland development are largely unknown. The GRHL2 transcription factor and its target gene product SPINT1 as well as the SPINT1-regualted protease matriptase play crucial roles in epithelial development in several organs. Here we examined the expression of these epithelial regulators in developing mouse SMG. Of the three Grhl gene members, Grhl2 was the most abundant in embryonic SMG. The expression levels of GRHL2, SPINT1 and matriptase were increased during development of the gland. All of these molecules were expressed exclusively in the epithelial tissue. The present data may suggest the involvement of these molecules in SMG development and give a clue to developing a regenerative therapy of damaged salivary glands.</description><identifier>ISSN: 1348-9623</identifier><identifier>EISSN: 1880-0823</identifier><identifier>DOI: 10.11223/jarde.14.98</identifier><language>eng</language><publisher>Okayama: Japanese Association of Regenerative Dentistry</publisher><subject>Damage ; Development ; Differentiation ; Embryos ; Exocrine glands ; Gene expression ; Glands ; Grhl2 ; Matriptase ; Morphogenesis ; Organs ; Regulators ; Salivary gland ; Salivary glands ; SPINT1 ; Submandibular gland ; Transcription factors</subject><ispartof>Journal of Oral Tissue Engineering, 2016, Vol.14(2), pp.98-106</ispartof><rights>2016 by Japanese Association of Regenerative Dentistry</rights><rights>Copyright Japan Science and Technology Agency 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>MATSUSHITA, Takumi</creatorcontrib><creatorcontrib>SAKAI, Takayoshi</creatorcontrib><creatorcontrib>YOSHIDA, Hiroaki</creatorcontrib><creatorcontrib>MORITA, Shosuke</creatorcontrib><creatorcontrib>Deprtment of Oral-facial Disorders</creatorcontrib><creatorcontrib>Osaka University Graduate School of Dentistry</creatorcontrib><creatorcontrib>Graduate School of Dentistry (Department of Oral and Maxillofacial Surgery Osaka Dental University</creatorcontrib><creatorcontrib>Department of Oral and Maxillofacial Surgery</creatorcontrib><creatorcontrib>Osaka Dental University</creatorcontrib><title>Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland</title><title>Journal of Oral Tissue Engineering</title><addtitle>J. Oral Tissue Engin.</addtitle><description>Development of the salivary gland is characterized by extensive branching morphogenesis and lumen formation as well as differentiation into acinar and ductal cells. Although various molecules have been implicated in salivary gland development, transcription factors regulating the expression of those molecules and salivary gland development are largely unknown. The GRHL2 transcription factor and its target gene product SPINT1 as well as the SPINT1-regualted protease matriptase play crucial roles in epithelial development in several organs. Here we examined the expression of these epithelial regulators in developing mouse SMG. Of the three Grhl gene members, Grhl2 was the most abundant in embryonic SMG. The expression levels of GRHL2, SPINT1 and matriptase were increased during development of the gland. All of these molecules were expressed exclusively in the epithelial tissue. The present data may suggest the involvement of these molecules in SMG development and give a clue to developing a regenerative therapy of damaged salivary glands.</description><subject>Damage</subject><subject>Development</subject><subject>Differentiation</subject><subject>Embryos</subject><subject>Exocrine glands</subject><subject>Gene expression</subject><subject>Glands</subject><subject>Grhl2</subject><subject>Matriptase</subject><subject>Morphogenesis</subject><subject>Organs</subject><subject>Regulators</subject><subject>Salivary gland</subject><subject>Salivary glands</subject><subject>SPINT1</subject><subject>Submandibular gland</subject><subject>Transcription factors</subject><issn>1348-9623</issn><issn>1880-0823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpFUU1LJDEQDcsKOzvubX9AwHOP-ep0-iLIOPYKLiuo4C2k09UzaXqSMekW_fcbGcVD1Suq3nsFVQj9pmRFKWP8fDCxgxUVq1p9QwuqFCmIYvx7rrlQRS0Z_4F-pjQQUsqaVgv0tHk9REjJBY9Dj5u4Gxk2vsM3U8IPJm5hwg14wHcxdLPNTefxFbzAGA7Ob_HfMCfA93O7zyLXzqOJuBlzfYpOejMm-PWBS_R4vXlY_ylu_zU368vbYuCyUkWnKkpYX9oWwNREcZs7tWzLVvV1VdvScCZbW3YVIVYoDqSkXW9NSUvBFG35Ep0dfQ8xPM-QJj2EOfq8UlNVCVFRmWVL1BxZe-icNWPwo_PwRe0cD3FySTNCpSaECsIyiBy10oQSyfIduZLZ6eLoNKTJbEEfotub-KZNltsxW76_QFOh2XvK4s-B3ZmowfP_KYmATA</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>MATSUSHITA, Takumi</creator><creator>SAKAI, Takayoshi</creator><creator>YOSHIDA, Hiroaki</creator><creator>MORITA, Shosuke</creator><general>Japanese Association of Regenerative Dentistry</general><general>Japan Science and Technology Agency</general><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>2016</creationdate><title>Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland</title><author>MATSUSHITA, Takumi ; SAKAI, Takayoshi ; YOSHIDA, Hiroaki ; MORITA, Shosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j3678-d87102f5cbeea9083cd8796b5b8f979c5a326bc5d700c483e051dfca5154281b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Damage</topic><topic>Development</topic><topic>Differentiation</topic><topic>Embryos</topic><topic>Exocrine glands</topic><topic>Gene expression</topic><topic>Glands</topic><topic>Grhl2</topic><topic>Matriptase</topic><topic>Morphogenesis</topic><topic>Organs</topic><topic>Regulators</topic><topic>Salivary gland</topic><topic>Salivary glands</topic><topic>SPINT1</topic><topic>Submandibular gland</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MATSUSHITA, Takumi</creatorcontrib><creatorcontrib>SAKAI, Takayoshi</creatorcontrib><creatorcontrib>YOSHIDA, Hiroaki</creatorcontrib><creatorcontrib>MORITA, Shosuke</creatorcontrib><creatorcontrib>Deprtment of Oral-facial Disorders</creatorcontrib><creatorcontrib>Osaka University Graduate School of Dentistry</creatorcontrib><creatorcontrib>Graduate School of Dentistry (Department of Oral and Maxillofacial Surgery Osaka Dental University</creatorcontrib><creatorcontrib>Department of Oral and Maxillofacial Surgery</creatorcontrib><creatorcontrib>Osaka Dental University</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of Oral Tissue Engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATSUSHITA, Takumi</au><au>SAKAI, Takayoshi</au><au>YOSHIDA, Hiroaki</au><au>MORITA, Shosuke</au><aucorp>Deprtment of Oral-facial Disorders</aucorp><aucorp>Osaka University Graduate School of Dentistry</aucorp><aucorp>Graduate School of Dentistry (Department of Oral and Maxillofacial Surgery Osaka Dental University</aucorp><aucorp>Department of Oral and Maxillofacial Surgery</aucorp><aucorp>Osaka Dental University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland</atitle><jtitle>Journal of Oral Tissue Engineering</jtitle><addtitle>J. Oral Tissue Engin.</addtitle><date>2016</date><risdate>2016</risdate><volume>14</volume><issue>2</issue><spage>98</spage><epage>106</epage><pages>98-106</pages><issn>1348-9623</issn><eissn>1880-0823</eissn><abstract>Development of the salivary gland is characterized by extensive branching morphogenesis and lumen formation as well as differentiation into acinar and ductal cells. Although various molecules have been implicated in salivary gland development, transcription factors regulating the expression of those molecules and salivary gland development are largely unknown. The GRHL2 transcription factor and its target gene product SPINT1 as well as the SPINT1-regualted protease matriptase play crucial roles in epithelial development in several organs. Here we examined the expression of these epithelial regulators in developing mouse SMG. Of the three Grhl gene members, Grhl2 was the most abundant in embryonic SMG. The expression levels of GRHL2, SPINT1 and matriptase were increased during development of the gland. All of these molecules were expressed exclusively in the epithelial tissue. The present data may suggest the involvement of these molecules in SMG development and give a clue to developing a regenerative therapy of damaged salivary glands.</abstract><cop>Okayama</cop><pub>Japanese Association of Regenerative Dentistry</pub><doi>10.11223/jarde.14.98</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Oral Tissue Engineering, 2016, Vol.14(2), pp.98-106 |
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| language | eng |
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| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Damage Development Differentiation Embryos Exocrine glands Gene expression Glands Grhl2 Matriptase Morphogenesis Organs Regulators Salivary gland Salivary glands SPINT1 Submandibular gland Transcription factors |
| title | Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland |
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