Frontispiece: Mechanistic Study of the Stereoselective Hydroxylation of [2‐2H1,3‐2H1]Butanes Catalyzed by Cytochrome P450 BM3 Variants

Catalytic mechanism of cytochrome P450 A high H/D kinetic isotope effect (KIE) (18–25) is observed from the hydroxylation of tailored di‐deuterated butane substrate, (2S,3S)‐[2‐2H1,3‐2H1]butane, mediated by engineered cytochrome P450 BM3. For the first time, the experimental evidence that supports t...

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Veröffentlicht in:	Chemistry : a European journal 2017-02, Vol.23 (11), p.n/a
Hauptverfasser:	Yang, Chung‐Ling, Lin, Cheng‐Hung, Luo, Wen‐I, Lee, Tsu‐Lin, Ramu, Ravirala, Ng, Kok Yaoh, Tsai, Yi‐Fang, Wei, Guor‐Tzo, Yu, Steve S.‐F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Cytochrome cytochrome P450 enzyme catalysis heme proteins isotope effects oxidation stereoselectivity
Online-Zugang:	Volltext
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