Polyphenols from sorbus aucuparia ameliorate insulin resistance and metabolic disorders in diabetic mice
The aim of this study was designed to evaluate the effects of Sorbus aucuparia fruit Polyphenols (SAFP) against high-glucose-fat diet (HGFD) combined with Streptozocin (STZ) induced diabetes in Kunming mice. The model mice were fed by water or SAFP (10, 50 or 100 mg.L^sup -1^) fluid for 4 weeks. As...
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| description | The aim of this study was designed to evaluate the effects of Sorbus aucuparia fruit Polyphenols (SAFP) against high-glucose-fat diet (HGFD) combined with Streptozocin (STZ) induced diabetes in Kunming mice. The model mice were fed by water or SAFP (10, 50 or 100 mg.L^sup -1^) fluid for 4 weeks. As a comparison, mice were fed by a normal-fat (ND) and water. The HGFD group developed more severe symptoms of metabolic syndrome than the ND group. SAFP treatment significantly ameliorated metabolic disorders such as hyperglycemia, dyslipidemia and insulin resistance in diabetic mice. Furthermore, SAFP lowered MDA and improved the activity of SOD and GSH-Px in serum. Histopathological examination indicated that the impaired hepatic tissues were effectively restored in diabetic mice following the SAFP treatment. Moreover, SAFP markedly up-regulated protein levels for insulin receptor (IR), insulin receptor substrate-1 (IRS-1), p-AKT and p-GSK3β in the liver and enhanced the insulin signaling pathway. This is the first report documenting that S. aucuparia fruit Polyphenols can ameliorate the HGFD combined with STZ induced insulin resistance and metabolic syndrome. |
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The model mice were fed by water or SAFP (10, 50 or 100 mg.L^sup -1^) fluid for 4 weeks. As a comparison, mice were fed by a normal-fat (ND) and water. The HGFD group developed more severe symptoms of metabolic syndrome than the ND group. SAFP treatment significantly ameliorated metabolic disorders such as hyperglycemia, dyslipidemia and insulin resistance in diabetic mice. Furthermore, SAFP lowered MDA and improved the activity of SOD and GSH-Px in serum. Histopathological examination indicated that the impaired hepatic tissues were effectively restored in diabetic mice following the SAFP treatment. Moreover, SAFP markedly up-regulated protein levels for insulin receptor (IR), insulin receptor substrate-1 (IRS-1), p-AKT and p-GSK3β in the liver and enhanced the insulin signaling pathway. This is the first report documenting that S. aucuparia fruit Polyphenols can ameliorate the HGFD combined with STZ induced insulin resistance and metabolic syndrome.</description><identifier>ISSN: 1540-7535</identifier><identifier>EISSN: 2641-452X</identifier><language>eng</language><publisher>Coppell: New Century Health Publishers, LLC</publisher><subject>Bioengineering ; Care and treatment ; Cholesterol ; Diabetes ; Diet ; Ethanol ; Glucose ; Grants ; Health aspects ; Hyperglycemia ; Insulin resistance ; Kinases ; Laboratory animals ; Lipid peroxidation ; Lipids ; Metabolism ; Phosphorylation ; Polyphenols ; Proteins ; Studies</subject><ispartof>Current topics in nutraceuticals research, 2016-08, Vol.14 (3), p.227</ispartof><rights>COPYRIGHT 2016 New Century Health Publishers, LLC</rights><rights>Copyright New Century Health Publishers, LLC Aug 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids></links><search><creatorcontrib>Wei, Jie</creatorcontrib><creatorcontrib>Zhang, Guokun</creatorcontrib><creatorcontrib>Zhang, Xiao</creatorcontrib><creatorcontrib>Gao, Jun</creatorcontrib><creatorcontrib>Zhou, Zhiquan</creatorcontrib><creatorcontrib>Fan, Jungang</creatorcontrib><title>Polyphenols from sorbus aucuparia ameliorate insulin resistance and metabolic disorders in diabetic mice</title><title>Current topics in nutraceuticals research</title><description>The aim of this study was designed to evaluate the effects of Sorbus aucuparia fruit Polyphenols (SAFP) against high-glucose-fat diet (HGFD) combined with Streptozocin (STZ) induced diabetes in Kunming mice. 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This is the first report documenting that S. aucuparia fruit Polyphenols can ameliorate the HGFD combined with STZ induced insulin resistance and metabolic syndrome.</description><subject>Bioengineering</subject><subject>Care and treatment</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Ethanol</subject><subject>Glucose</subject><subject>Grants</subject><subject>Health aspects</subject><subject>Hyperglycemia</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Metabolism</subject><subject>Phosphorylation</subject><subject>Polyphenols</subject><subject>Proteins</subject><subject>Studies</subject><issn>1540-7535</issn><issn>2641-452X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptj01LxDAQhosouK7-h4DgrZLPbntcFr9gQQ978Fam6XSbJU3WJD347w0ouILMYZiX55lhzooFryQrpeLv58WCKUnLlRLqsriK8UBpJXjNF8X45u3ncUTnbSRD8BOJPnRzJDDr-QjBAIEJrfEBEhLj4myNIwGjiQmcRgKuJxMm6Lw1mvQm6z2GmNE8QIcpp5PReF1cDGAj3vz0ZbF7fNhtnsvt69PLZr0t95yxVOqeNZ2gXMiBSg5s0Eo0WmmqucauqWSvqEYYoAfeKaZ1BY0ECn1dC2CdWBa332uPwX_MGFN78HNw-WLL6hVtaN2sql9qDxZb4wafAujJRN2u5apppKBKZur-HypXj_kj73AwOf8j3J0II4JNY_R2Tsa7eAp-AbiDfyg</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Wei, Jie</creator><creator>Zhang, Guokun</creator><creator>Zhang, Xiao</creator><creator>Gao, Jun</creator><creator>Zhou, Zhiquan</creator><creator>Fan, Jungang</creator><general>New Century Health Publishers, LLC</general><scope>3V.</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20160801</creationdate><title>Polyphenols from sorbus aucuparia ameliorate insulin resistance and metabolic disorders in diabetic mice</title><author>Wei, Jie ; 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The model mice were fed by water or SAFP (10, 50 or 100 mg.L^sup -1^) fluid for 4 weeks. As a comparison, mice were fed by a normal-fat (ND) and water. The HGFD group developed more severe symptoms of metabolic syndrome than the ND group. SAFP treatment significantly ameliorated metabolic disorders such as hyperglycemia, dyslipidemia and insulin resistance in diabetic mice. Furthermore, SAFP lowered MDA and improved the activity of SOD and GSH-Px in serum. Histopathological examination indicated that the impaired hepatic tissues were effectively restored in diabetic mice following the SAFP treatment. Moreover, SAFP markedly up-regulated protein levels for insulin receptor (IR), insulin receptor substrate-1 (IRS-1), p-AKT and p-GSK3β in the liver and enhanced the insulin signaling pathway. This is the first report documenting that S. aucuparia fruit Polyphenols can ameliorate the HGFD combined with STZ induced insulin resistance and metabolic syndrome.</abstract><cop>Coppell</cop><pub>New Century Health Publishers, LLC</pub></addata></record> |
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| subjects | Bioengineering Care and treatment Cholesterol Diabetes Diet Ethanol Glucose Grants Health aspects Hyperglycemia Insulin resistance Kinases Laboratory animals Lipid peroxidation Lipids Metabolism Phosphorylation Polyphenols Proteins Studies |
| title | Polyphenols from sorbus aucuparia ameliorate insulin resistance and metabolic disorders in diabetic mice |
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