G389(P) Does bladder drainage with intermittent catheterisation preserve kidney function in boys with posterior urethral valves?
BackgroundPosterior urethral valves (PUV) is the commonest congenital urinary tract anomaly associated with progression to end stage renal disease (ESRD) in children, with bladder dysfunction being a major risk factor. The effect of bladder drainage with intermittent catheterisation on the rate of d...
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| Veröffentlicht in: | Archives of disease in childhood 2016-04, Vol.101 (Suppl 1), p.A226-A227 |
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| creator | Doheny-Shanley, J Woodward, M Hayes, W |
| description | BackgroundPosterior urethral valves (PUV) is the commonest congenital urinary tract anomaly associated with progression to end stage renal disease (ESRD) in children, with bladder dysfunction being a major risk factor. The effect of bladder drainage with intermittent catheterisation on the rate of decline in renal function has not previously been assessed.MethodsA retrospective analysis of changes in the rate of decline in renal function and the degree of hydronephrosis following initiation of bladder drainage was undertaken comparing 10 children undergoing drainage to controls in a single centre cohort of 58 patients with PUV.ResultsIn the cohort, maximal renal pelvis diameter > 25mm was associated with increased risk of ESRD (p = 0.005). In patients with bladder dysfunction, initiation of bladder drainage was associated with reduction in hydronephrosis (p < 0.001) but no significant reduction in the rate of decline of renal function (p = 0.6).ConclusionsIn patients with PUV and bladder dysfunction, initiation of catheter bladder drainage was associated with reduction in hydronephrosis. Whilst no reduction in the rate of decline of renal function was observed in this retrospective analysis, a prospective randomised evaluation of the long-term effect of bladder drainage on renal function is merited. |
| doi_str_mv | 10.1136/archdischild-2016-310863.379 |
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The effect of bladder drainage with intermittent catheterisation on the rate of decline in renal function has not previously been assessed.MethodsA retrospective analysis of changes in the rate of decline in renal function and the degree of hydronephrosis following initiation of bladder drainage was undertaken comparing 10 children undergoing drainage to controls in a single centre cohort of 58 patients with PUV.ResultsIn the cohort, maximal renal pelvis diameter > 25mm was associated with increased risk of ESRD (p = 0.005). In patients with bladder dysfunction, initiation of bladder drainage was associated with reduction in hydronephrosis (p < 0.001) but no significant reduction in the rate of decline of renal function (p = 0.6).ConclusionsIn patients with PUV and bladder dysfunction, initiation of catheter bladder drainage was associated with reduction in hydronephrosis. Whilst no reduction in the rate of decline of renal function was observed in this retrospective analysis, a prospective randomised evaluation of the long-term effect of bladder drainage on renal function is merited.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/archdischild-2016-310863.379</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Medical instruments ; Patients ; Renal function ; Risk factors</subject><ispartof>Archives of disease in childhood, 2016-04, Vol.101 (Suppl 1), p.A226-A227</ispartof><rights>2016, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2016 (c) 2016, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://adc.bmj.com/content/101/Suppl_1/A226.2.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://adc.bmj.com/content/101/Suppl_1/A226.2.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids></links><search><creatorcontrib>Doheny-Shanley, J</creatorcontrib><creatorcontrib>Woodward, M</creatorcontrib><creatorcontrib>Hayes, W</creatorcontrib><title>G389(P) Does bladder drainage with intermittent catheterisation preserve kidney function in boys with posterior urethral valves?</title><title>Archives of disease in childhood</title><description>BackgroundPosterior urethral valves (PUV) is the commonest congenital urinary tract anomaly associated with progression to end stage renal disease (ESRD) in children, with bladder dysfunction being a major risk factor. The effect of bladder drainage with intermittent catheterisation on the rate of decline in renal function has not previously been assessed.MethodsA retrospective analysis of changes in the rate of decline in renal function and the degree of hydronephrosis following initiation of bladder drainage was undertaken comparing 10 children undergoing drainage to controls in a single centre cohort of 58 patients with PUV.ResultsIn the cohort, maximal renal pelvis diameter > 25mm was associated with increased risk of ESRD (p = 0.005). In patients with bladder dysfunction, initiation of bladder drainage was associated with reduction in hydronephrosis (p < 0.001) but no significant reduction in the rate of decline of renal function (p = 0.6).ConclusionsIn patients with PUV and bladder dysfunction, initiation of catheter bladder drainage was associated with reduction in hydronephrosis. Whilst no reduction in the rate of decline of renal function was observed in this retrospective analysis, a prospective randomised evaluation of the long-term effect of bladder drainage on renal function is merited.</description><subject>Medical instruments</subject><subject>Patients</subject><subject>Renal function</subject><subject>Risk factors</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVkM9q3DAQxkVJoJtN30HQHpKDNxrbkiUIlLJtNoVAcmjPQv9ca-u1N5K8YW8hkBftk8Qb95BrTsPMfN83zA-hL0AWAAW7UME01kfT-NZmOQGWFUA4KxZFJT6gGZSMj-OyPEIzQkiRCc75R3QS45oQyDkvZuhpVXBxdnf-7_H5e-8i1q2y1gVsg_Kd-uPwg08N9l1yYeNTcl3CRqXGjb2PKvm-w9vgogs7h_9627k9rofOvC58h3W_j1PEto8HTx_wEFxqgmrxTrU7F7-eouNatdF9-l_n6PfVj1_L6-zmdvVz-e0m05ALnlFNjRUGQFFOAKgV42dag6qY4ZozRmuiwCpTKkGFqQQhFMByqrmiec2KOfo85W5Dfz-4mOS6H0I3npTAK8JolZd8VF1OKhP6GIOr5Tb4jQp7CUQeqMu31OWBupyoy5H6aK8mu96s3-d8AejVjoc</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Doheny-Shanley, J</creator><creator>Woodward, M</creator><creator>Hayes, W</creator><general>BMJ Publishing Group LTD</general><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>201604</creationdate><title>G389(P) Does bladder drainage with intermittent catheterisation preserve kidney function in boys with posterior urethral valves?</title><author>Doheny-Shanley, J ; Woodward, M ; Hayes, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1298-5b5cd9c11a580115d9044bb1a76c8b8665f0a1dac4a959c7900511d85b8a52f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Medical instruments</topic><topic>Patients</topic><topic>Renal function</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doheny-Shanley, J</creatorcontrib><creatorcontrib>Woodward, M</creatorcontrib><creatorcontrib>Hayes, W</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Education Journals</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doheny-Shanley, J</au><au>Woodward, M</au><au>Hayes, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>G389(P) Does bladder drainage with intermittent catheterisation preserve kidney function in boys with posterior urethral valves?</atitle><jtitle>Archives of disease in childhood</jtitle><date>2016-04</date><risdate>2016</risdate><volume>101</volume><issue>Suppl 1</issue><spage>A226</spage><epage>A227</epage><pages>A226-A227</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>BackgroundPosterior urethral valves (PUV) is the commonest congenital urinary tract anomaly associated with progression to end stage renal disease (ESRD) in children, with bladder dysfunction being a major risk factor. The effect of bladder drainage with intermittent catheterisation on the rate of decline in renal function has not previously been assessed.MethodsA retrospective analysis of changes in the rate of decline in renal function and the degree of hydronephrosis following initiation of bladder drainage was undertaken comparing 10 children undergoing drainage to controls in a single centre cohort of 58 patients with PUV.ResultsIn the cohort, maximal renal pelvis diameter > 25mm was associated with increased risk of ESRD (p = 0.005). In patients with bladder dysfunction, initiation of bladder drainage was associated with reduction in hydronephrosis (p < 0.001) but no significant reduction in the rate of decline of renal function (p = 0.6).ConclusionsIn patients with PUV and bladder dysfunction, initiation of catheter bladder drainage was associated with reduction in hydronephrosis. Whilst no reduction in the rate of decline of renal function was observed in this retrospective analysis, a prospective randomised evaluation of the long-term effect of bladder drainage on renal function is merited.</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/archdischild-2016-310863.379</doi></addata></record> |
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| title | G389(P) Does bladder drainage with intermittent catheterisation preserve kidney function in boys with posterior urethral valves? |
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