Nucleostemin/GNL3 promotes nucleolar polyubiquitylation of p27kip1to drive hepatocellular carcinoma progression

p27kip, as a cyclin dependent kinase inhibitor (CDKI), plays a pivotal role in the regulation of cell cycle progression and hepatocarcinogenesis. Herein, we revealed that p27 exhibited apparent nucleolar distribution and interacted with nucleolar protein nucleostemin (NS) in Hepatocellular carcinoma...

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Veröffentlicht in:	Cancer letters 2017-03, Vol.388, p.220
Hauptverfasser:	Hu, Baoying, Hua, Lu, Ni, Wenkai, Wu, Miaomiao, Yan, Daliang, Chen, Yuyan, Lu, Cuihua, Chen, Buyou, Wan, Chunhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell cycle Cell growth Cyclin-dependent kinases Cytoplasm Immunoglobulins Kinases Liver cancer Localization Medical prognosis Phase transitions Proteins Stem cells Studies Tumorigenesis
Online-Zugang:	Volltext
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