Hyper-Endorphin Syndrome in a Child with Necrotizing Encephalomyelopathy
SUBACUTE necrotizing encephalomyelopathy, or Leigh's syndrome, 1 is a degenerative disorder characterized by progressive deterioration of brain-stem functions, ataxia, convulsions, hypotonia, and failure to thrive. The histopathologic changes are found in the brain stem, basal ganglia, cerebell...
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| Veröffentlicht in: | The New England journal of medicine 1980-10, Vol.303 (16), p.914-916 |
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| container_title | The New England journal of medicine |
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| creator | Brandt, Niels Jacob Brandt, Sven Terenius, Lars Jacobsen, Bendt Brock Klinken, Leif Nordius, Åsa Blegvad, Karin Yssing, Minna |
| description | SUBACUTE necrotizing encephalomyelopathy, or Leigh's syndrome,
1
is a degenerative disorder characterized by progressive deterioration of brain-stem functions, ataxia, convulsions, hypotonia, and failure to thrive. The histopathologic changes are found in the brain stem, basal ganglia, cerebellar cortex, and dentate nucleus, and they consist of bilateral symmetrical areas of rarefaction, loss of myelin, and cell proliferation in the capillaries and glia. This disorder occurs in infancy and early childhood and is inherited as an autosomal-recessive trait, but the basic biochemical defect is unknown.
We report on a syndrome in a boy suffering from attacks mimicking acute morphine poisoning with prolonged apnea . . . |
| doi_str_mv | 10.1056/NEJM198010163031604 |
| format | Article |
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1
is a degenerative disorder characterized by progressive deterioration of brain-stem functions, ataxia, convulsions, hypotonia, and failure to thrive. The histopathologic changes are found in the brain stem, basal ganglia, cerebellar cortex, and dentate nucleus, and they consist of bilateral symmetrical areas of rarefaction, loss of myelin, and cell proliferation in the capillaries and glia. This disorder occurs in infancy and early childhood and is inherited as an autosomal-recessive trait, but the basic biochemical defect is unknown.
We report on a syndrome in a boy suffering from attacks mimicking acute morphine poisoning with prolonged apnea . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198010163031604</identifier><identifier>PMID: 7412823</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Ataxia ; Ataxia - etiology ; Brain - pathology ; Brain Chemistry ; Brain Diseases - diagnosis ; Brain Diseases - pathology ; Brain Diseases - physiopathology ; Case reports ; Cerebrospinal Fluid - analysis ; Dehydrogenases ; Diagnosis, Differential ; Endorphins ; Endorphins - analysis ; Endorphins - physiology ; Enkephalins - analysis ; Enkephalins - physiology ; Fibroblasts ; Humans ; Infant ; Injections, Intravenous ; Intellectual Disability - etiology ; Male ; Metabolism ; Metabolites ; Morphine - poisoning ; Naloxone - administration & dosage ; Naloxone - therapeutic use ; Narcotics ; Necrosis ; Pediatrics ; Peptides ; Poisoning ; Respiration ; Spinal Cord Diseases - diagnosis ; Spinal Cord Diseases - pathology ; Spinal Cord Diseases - physiopathology ; Syndrome ; Urine</subject><ispartof>The New England journal of medicine, 1980-10, Vol.303 (16), p.914-916</ispartof><rights>Copyright Massachusetts Medical Society Oct 16, 1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-bee3692deceace0d6a79aa74cc1b10356ef6326583dab2d2ea91c51a520e0b882</citedby><cites>FETCH-LOGICAL-c364t-bee3692deceace0d6a79aa74cc1b10356ef6326583dab2d2ea91c51a520e0b882</cites></display><links><openurl>$$Topenurl_article</openurl><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7412823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brandt, Niels Jacob</creatorcontrib><creatorcontrib>Brandt, Sven</creatorcontrib><creatorcontrib>Terenius, Lars</creatorcontrib><creatorcontrib>Jacobsen, Bendt Brock</creatorcontrib><creatorcontrib>Klinken, Leif</creatorcontrib><creatorcontrib>Nordius, Åsa</creatorcontrib><creatorcontrib>Blegvad, Karin</creatorcontrib><creatorcontrib>Yssing, Minna</creatorcontrib><title>Hyper-Endorphin Syndrome in a Child with Necrotizing Encephalomyelopathy</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>SUBACUTE necrotizing encephalomyelopathy, or Leigh's syndrome,
1
is a degenerative disorder characterized by progressive deterioration of brain-stem functions, ataxia, convulsions, hypotonia, and failure to thrive. The histopathologic changes are found in the brain stem, basal ganglia, cerebellar cortex, and dentate nucleus, and they consist of bilateral symmetrical areas of rarefaction, loss of myelin, and cell proliferation in the capillaries and glia. This disorder occurs in infancy and early childhood and is inherited as an autosomal-recessive trait, but the basic biochemical defect is unknown.
We report on a syndrome in a boy suffering from attacks mimicking acute morphine poisoning with prolonged apnea . . .</description><subject>Ataxia</subject><subject>Ataxia - etiology</subject><subject>Brain - pathology</subject><subject>Brain Chemistry</subject><subject>Brain Diseases - diagnosis</subject><subject>Brain Diseases - pathology</subject><subject>Brain Diseases - physiopathology</subject><subject>Case reports</subject><subject>Cerebrospinal Fluid - analysis</subject><subject>Dehydrogenases</subject><subject>Diagnosis, Differential</subject><subject>Endorphins</subject><subject>Endorphins - analysis</subject><subject>Endorphins - physiology</subject><subject>Enkephalins - analysis</subject><subject>Enkephalins - physiology</subject><subject>Fibroblasts</subject><subject>Humans</subject><subject>Infant</subject><subject>Injections, Intravenous</subject><subject>Intellectual Disability - etiology</subject><subject>Male</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Morphine - poisoning</subject><subject>Naloxone - administration & dosage</subject><subject>Naloxone - therapeutic use</subject><subject>Narcotics</subject><subject>Necrosis</subject><subject>Pediatrics</subject><subject>Peptides</subject><subject>Poisoning</subject><subject>Respiration</subject><subject>Spinal Cord Diseases - diagnosis</subject><subject>Spinal Cord Diseases - pathology</subject><subject>Spinal Cord Diseases - physiopathology</subject><subject>Syndrome</subject><subject>Urine</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>false</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9UEtLxDAQDqKs6-ovEKHgUaqZJE2boyzVVdb1oJ5LmszaLn2ZdpH6643s4kmcywx8j5n5CDkHeg00kjer9PEJVEKBguSUg6TigEwh4jwUgspDMqWUJaGIFT8mJ32_ob5AqAmZxAJYwviULBZjhy5MG9u6riib4GVsrGtrDPysg3lRVjb4LIciWKFx7VB-lc17kDYGu0JXbT1i1XZ6KMZTcrTWVY9n-z4jb3fp63wRLp_vH-a3y9BwKYYwR-RSMYsGtUFqpY6V1rEwBnKgPJK4lpzJKOFW58wy1ApMBDpiFGmeJGxGLne-nWs_ttgP2abdusavzCCRKvLPcuVZfMfyN_e9w3XWubLWbsyAZj_hZX-E51UXe-9tXqP91ezT8vjVDq_rPmtwU__r9g3Ii3Y3</recordid><startdate>19801016</startdate><enddate>19801016</enddate><creator>Brandt, Niels Jacob</creator><creator>Brandt, Sven</creator><creator>Terenius, Lars</creator><creator>Jacobsen, Bendt Brock</creator><creator>Klinken, Leif</creator><creator>Nordius, Åsa</creator><creator>Blegvad, Karin</creator><creator>Yssing, Minna</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19801016</creationdate><title>Hyper-Endorphin Syndrome in a Child with Necrotizing Encephalomyelopathy</title><author>Brandt, Niels Jacob ; Brandt, Sven ; Terenius, Lars ; Jacobsen, Bendt Brock ; Klinken, Leif ; Nordius, Åsa ; Blegvad, Karin ; Yssing, Minna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-bee3692deceace0d6a79aa74cc1b10356ef6326583dab2d2ea91c51a520e0b882</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Ataxia</topic><topic>Ataxia - 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diagnosis</topic><topic>Spinal Cord Diseases - pathology</topic><topic>Spinal Cord Diseases - physiopathology</topic><topic>Syndrome</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><creatorcontrib>Brandt, Niels Jacob</creatorcontrib><creatorcontrib>Brandt, Sven</creatorcontrib><creatorcontrib>Terenius, Lars</creatorcontrib><creatorcontrib>Jacobsen, Bendt Brock</creatorcontrib><creatorcontrib>Klinken, Leif</creatorcontrib><creatorcontrib>Nordius, Åsa</creatorcontrib><creatorcontrib>Blegvad, Karin</creatorcontrib><creatorcontrib>Yssing, Minna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>no_fulltext</fulltext></delivery><addata><au>Brandt, Niels Jacob</au><au>Brandt, Sven</au><au>Terenius, Lars</au><au>Jacobsen, Bendt Brock</au><au>Klinken, Leif</au><au>Nordius, Åsa</au><au>Blegvad, Karin</au><au>Yssing, Minna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyper-Endorphin Syndrome in a Child with Necrotizing Encephalomyelopathy</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1980-10-16</date><risdate>1980</risdate><volume>303</volume><issue>16</issue><spage>914</spage><epage>916</epage><pages>914-916</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>SUBACUTE necrotizing encephalomyelopathy, or Leigh's syndrome,
1
is a degenerative disorder characterized by progressive deterioration of brain-stem functions, ataxia, convulsions, hypotonia, and failure to thrive. The histopathologic changes are found in the brain stem, basal ganglia, cerebellar cortex, and dentate nucleus, and they consist of bilateral symmetrical areas of rarefaction, loss of myelin, and cell proliferation in the capillaries and glia. This disorder occurs in infancy and early childhood and is inherited as an autosomal-recessive trait, but the basic biochemical defect is unknown.
We report on a syndrome in a boy suffering from attacks mimicking acute morphine poisoning with prolonged apnea . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>7412823</pmid><doi>10.1056/NEJM198010163031604</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1980-10, Vol.303 (16), p.914-916 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE |
| subjects | Ataxia Ataxia - etiology Brain - pathology Brain Chemistry Brain Diseases - diagnosis Brain Diseases - pathology Brain Diseases - physiopathology Case reports Cerebrospinal Fluid - analysis Dehydrogenases Diagnosis, Differential Endorphins Endorphins - analysis Endorphins - physiology Enkephalins - analysis Enkephalins - physiology Fibroblasts Humans Infant Injections, Intravenous Intellectual Disability - etiology Male Metabolism Metabolites Morphine - poisoning Naloxone - administration & dosage Naloxone - therapeutic use Narcotics Necrosis Pediatrics Peptides Poisoning Respiration Spinal Cord Diseases - diagnosis Spinal Cord Diseases - pathology Spinal Cord Diseases - physiopathology Syndrome Urine |
| title | Hyper-Endorphin Syndrome in a Child with Necrotizing Encephalomyelopathy |
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