Isolated BAL Neutrophilia and Unimodal Airway Epithelial IL-13 Inducible Gene Signatures Characterize Children with Treatment-Resistant Asthma

Isolated BAL Neutrophilia and Unimodal Airway Epithelial IL-13 Inducible Gene Signatures Characterize Children with Treatment-Resistant Asthma

Unlike studies of adults with milder asthma on low-dose ICS, we could not identify a bimodal pattern of Th2 HIGH and LOW gene expression profiles, likely due to the suppressive effects of high-dose corticosteroid treatment in our sample.

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Veröffentlicht in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB181-AB181
Hauptverfasser: Borish, Larry, MD, FAAAAI, Braciale, Thomas J., MD, PhD, Shirley, Debbie-Ann, MD, Steinke, John W., PhD, FAAAAI, Williams, Sandford, MS, Pollack, Karlyn, BS, Capaldo, Brian J., PhD, Teague, W. Gerald, MD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Asthma
Gene expression
Granulocytes
Pathogens
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Zusammenfassung:Unlike studies of adults with milder asthma on low-dose ICS, we could not identify a bimodal pattern of Th2 HIGH and LOW gene expression profiles, likely due to the suppressive effects of high-dose corticosteroid treatment in our sample.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.591