Loss of [mu] opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

Opioid pain medications have detrimental side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). Tolerance and OIH counteract opioid analgesia and drive dose escalation. The cell types and receptors on which opioids act to initiate these maladaptive processes remain dispute...

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Veröffentlicht in:	Nature medicine 2017-02, Vol.23 (2), p.164
Hauptverfasser:	Corder, Gregory, Tawfik, Vivianne L, Wang, Dong, Sypek, Elizabeth I, Low, Sarah A, Dickinson, Jasmine R, Sotoudeh, Chaudy, Clark, J David, Barres, Ben A, Bohlen, Christopher J, Scherrer, Grégory
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics Cellular signal transduction Drug resistance Genetic aspects Health aspects Narcotics Opioid receptors Pain management Physiological aspects Side effects Signal transduction
Online-Zugang:	Volltext
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