Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis/ Survivin i vegf kao novi biomarkeri u dijagnostici endometrioze
Background: The aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis. Methods: This study included 40 patients undergoing laparoscopy for suspected endometriosis from Janua...
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| Veröffentlicht in: | Journal of medical biochemistry 2016-01, Vol.35 (1), p.63-68 |
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| creator | Acimovic, Milena Vidakovic, Snezana Milic, Natasa Jeremic, Katarina Markovic, Milos Milosevic-Djeric, Ana Lazovic-Radonjic, Gordana |
| description | Background: The aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis.
Methods: This study included 40 patients undergoing laparoscopy for suspected endometriosis from January to December 2012. Preoperative levels of serum CA125, CA19-9, CEA and mRNA expression levels for survivin and VEGF were obtained. Real-time PCR was used to determine relative gene expression. A new diagnostic score was obtained by deploying the peripheral blood markers to the TVU findings. Statistical methods used were Chi-square, Fisher’s, Student’s t-test or the Mann - Whitney test.
Results: There was a statistically significant difference in serum CA125, survivin and VEGF levels in patients with endometriosis and those without endometriosis (p |
| doi_str_mv | 10.1515/jomb-2015-0005 |
| format | Article |
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Methods: This study included 40 patients undergoing laparoscopy for suspected endometriosis from January to December 2012. Preoperative levels of serum CA125, CA19-9, CEA and mRNA expression levels for survivin and VEGF were obtained. Real-time PCR was used to determine relative gene expression. A new diagnostic score was obtained by deploying the peripheral blood markers to the TVU findings. Statistical methods used were Chi-square, Fisher’s, Student’s t-test or the Mann - Whitney test.
Results: There was a statistically significant difference in serum CA125, survivin and VEGF levels in patients with endometriosis and those without endometriosis (p<0.001, p=0.025 and p=0.009, respectively). False negative TVU findings were noted in 3/13 patients (23.1%) with peritoneal endometriosis without ovaries involvement. High sensitivity (93.3%), specificity (90.0%), PPV (96.6%), NPV (81.8%) and accuracy (92.5%) were obtained for a diagnostic score based on TVU and significant peripheral blood markers (CA125, survivin and VEGF).
Conclusions: Determination of serum CA125, mRNA expression levels for survivin and VEGF along with TVU can contribute to higher accuracy of the noninvasive diagnostic tools for endometriosis.
Uvod: Cilj ovog istraživanja je da se ispita značaj određivanja koncentracija serumskih biomarkera (CA125, CA19-9, CEA i ekspresije iRNK za survivin i VEGF) zajedno sa trans- vaginalnim ultrazvučnim pregledom (TVU) prilikom dijag- nostikovanja endometrioze.
Metode: Ova studija obuhvata 40 pacijentkinja kojima je zbog sumnje|na postojanje endometrioze urađena dijagnostička laparoskopija sa patohistološkom analizom u jednogodišnjem periodu od januara 2012. do decembra 2013. Preoperativno su određivane koncentracije CA125, CA19- 9, CEA kao i nivoi ekspresije iRNK za survivin i VEGF. Real- time PCR je korišćen za određivanje relativne ekspresije gena. Određivanjem vrednosti serumskih biomarkera zajedno sa TVU dobijen je novi dijagnostički skor. Statističke metode koje su korišćene su Hi kvadratni test, Fishe- rov, Studentov t test ili Mann-Whitney test.
Rezultati: Postoji statistički značajna razlika u serumskoj koncentraciji CA125, survivina i nivoa VEGF kod pacijentkinja sa endometriozom i onih bez endometrioze (p<0,001, p=0,025 i p=0,009). Lažno negativan nalaz TVU zabeležen je kod 3/13 pacijenata (23,1%) sa perito- nealnom endometriozom. Visoka osetljivost (93,3%), specifičnost (90,0%), PPV (96,6%), NPV (81,8%) i tačnost (92,5%) postižu se određivanjem koncentracija serumskih biomarkera (CA125, survivin i VEGF) i TVU.
Zaključak: Određivanje serumskih koncentracija CA125, nivoa ekspresije iRNK za survivin i VEGF zajedno sa TVU od velikog je kliničkog značaja u neinvazivnoj dijagnostici endometrioze.</description><identifier>ISSN: 1452-8266</identifier><identifier>ISSN: 1452-8258</identifier><identifier>EISSN: 1452-8266</identifier><identifier>DOI: 10.1515/jomb-2015-0005</identifier><language>eng</language><publisher>Belgrade: De Gruyter Open</publisher><subject>CA125 ; Endometriosis ; endometrioza ; lapa - roscopy ; lapa- roskopija ; survivin ; transvaginal ultrasound ; transvaginalni ultrazvuk ; VEGE CA125 ; VEGF</subject><ispartof>Journal of medical biochemistry, 2016-01, Vol.35 (1), p.63-68</ispartof><rights>Copyright De Gruyter Open Sp. z o.o. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1643-bd5906694703abd443039e13f159fa16b4615ec8506eb4c6e7c0a7a7ac582f8e3</citedby><cites>FETCH-LOGICAL-c1643-bd5906694703abd443039e13f159fa16b4615ec8506eb4c6e7c0a7a7ac582f8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Acimovic, Milena</creatorcontrib><creatorcontrib>Vidakovic, Snezana</creatorcontrib><creatorcontrib>Milic, Natasa</creatorcontrib><creatorcontrib>Jeremic, Katarina</creatorcontrib><creatorcontrib>Markovic, Milos</creatorcontrib><creatorcontrib>Milosevic-Djeric, Ana</creatorcontrib><creatorcontrib>Lazovic-Radonjic, Gordana</creatorcontrib><title>Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis/ Survivin i vegf kao novi biomarkeri u dijagnostici endometrioze</title><title>Journal of medical biochemistry</title><description>Background: The aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis.
Methods: This study included 40 patients undergoing laparoscopy for suspected endometriosis from January to December 2012. Preoperative levels of serum CA125, CA19-9, CEA and mRNA expression levels for survivin and VEGF were obtained. Real-time PCR was used to determine relative gene expression. A new diagnostic score was obtained by deploying the peripheral blood markers to the TVU findings. Statistical methods used were Chi-square, Fisher’s, Student’s t-test or the Mann - Whitney test.
Results: There was a statistically significant difference in serum CA125, survivin and VEGF levels in patients with endometriosis and those without endometriosis (p<0.001, p=0.025 and p=0.009, respectively). False negative TVU findings were noted in 3/13 patients (23.1%) with peritoneal endometriosis without ovaries involvement. High sensitivity (93.3%), specificity (90.0%), PPV (96.6%), NPV (81.8%) and accuracy (92.5%) were obtained for a diagnostic score based on TVU and significant peripheral blood markers (CA125, survivin and VEGF).
Conclusions: Determination of serum CA125, mRNA expression levels for survivin and VEGF along with TVU can contribute to higher accuracy of the noninvasive diagnostic tools for endometriosis.
Uvod: Cilj ovog istraživanja je da se ispita značaj određivanja koncentracija serumskih biomarkera (CA125, CA19-9, CEA i ekspresije iRNK za survivin i VEGF) zajedno sa trans- vaginalnim ultrazvučnim pregledom (TVU) prilikom dijag- nostikovanja endometrioze.
Metode: Ova studija obuhvata 40 pacijentkinja kojima je zbog sumnje|na postojanje endometrioze urađena dijagnostička laparoskopija sa patohistološkom analizom u jednogodišnjem periodu od januara 2012. do decembra 2013. Preoperativno su određivane koncentracije CA125, CA19- 9, CEA kao i nivoi ekspresije iRNK za survivin i VEGF. Real- time PCR je korišćen za određivanje relativne ekspresije gena. Određivanjem vrednosti serumskih biomarkera zajedno sa TVU dobijen je novi dijagnostički skor. Statističke metode koje su korišćene su Hi kvadratni test, Fishe- rov, Studentov t test ili Mann-Whitney test.
Rezultati: Postoji statistički značajna razlika u serumskoj koncentraciji CA125, survivina i nivoa VEGF kod pacijentkinja sa endometriozom i onih bez endometrioze (p<0,001, p=0,025 i p=0,009). Lažno negativan nalaz TVU zabeležen je kod 3/13 pacijenata (23,1%) sa perito- nealnom endometriozom. Visoka osetljivost (93,3%), specifičnost (90,0%), PPV (96,6%), NPV (81,8%) i tačnost (92,5%) postižu se određivanjem koncentracija serumskih biomarkera (CA125, survivin i VEGF) i TVU.
Zaključak: Određivanje serumskih koncentracija CA125, nivoa ekspresije iRNK za survivin i VEGF zajedno sa TVU od velikog je kliničkog značaja u neinvazivnoj dijagnostici endometrioze.</description><subject>CA125</subject><subject>Endometriosis</subject><subject>endometrioza</subject><subject>lapa - roscopy</subject><subject>lapa- roskopija</subject><subject>survivin</subject><subject>transvaginal ultrasound</subject><subject>transvaginalni ultrazvuk</subject><subject>VEGE CA125</subject><subject>VEGF</subject><issn>1452-8266</issn><issn>1452-8258</issn><issn>1452-8266</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkDtPwzAUhS0EEqWwMltiTutH7CRiglIeUgUDjzVykpvKaRsXOwkqMz8ch0LVAXnw0fU535UPQueUjKigYlyZVRYwQkVACBEHaEBDwYKYSXm4p4_RiXOVN8Q0iQbo67m1ne50jVVd4DeYl1g5_Gg6WOJrbVbKLsA67N9vtJrXxmmHTYmndWFW0FjdD8Z4B9G46xELZXBtOo2zP4TGLS509YNodK4x7AifcIqOSrV0cPZ7D9Hr7fRlch_Mnu4eJlezIKcy5EFWiIRImYQR4SorwpATngDlJRVJqajMQkkF5LEgErIwlxDlREX-5CJmZQx8iC623LU17y24Jq1Ma2u_MqWxFCyKGWPeNdq6cmucs1Cma6v9LzYpJWnfdNo3nfZNp33TPnC5DXyoZQO2gLltN17s0f8PCio5_wYwKYcD</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Acimovic, Milena</creator><creator>Vidakovic, Snezana</creator><creator>Milic, Natasa</creator><creator>Jeremic, Katarina</creator><creator>Markovic, Milos</creator><creator>Milosevic-Djeric, Ana</creator><creator>Lazovic-Radonjic, Gordana</creator><general>De Gruyter Open</general><general>Society of Medical Biochemists of Serbia</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope></search><sort><creationdate>20160101</creationdate><title>Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis/ Survivin i vegf kao novi biomarkeri u dijagnostici endometrioze</title><author>Acimovic, Milena ; Vidakovic, Snezana ; Milic, Natasa ; Jeremic, Katarina ; Markovic, Milos ; Milosevic-Djeric, Ana ; Lazovic-Radonjic, Gordana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1643-bd5906694703abd443039e13f159fa16b4615ec8506eb4c6e7c0a7a7ac582f8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>CA125</topic><topic>Endometriosis</topic><topic>endometrioza</topic><topic>lapa - roscopy</topic><topic>lapa- roskopija</topic><topic>survivin</topic><topic>transvaginal ultrasound</topic><topic>transvaginalni ultrazvuk</topic><topic>VEGE CA125</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Acimovic, Milena</creatorcontrib><creatorcontrib>Vidakovic, Snezana</creatorcontrib><creatorcontrib>Milic, Natasa</creatorcontrib><creatorcontrib>Jeremic, Katarina</creatorcontrib><creatorcontrib>Markovic, Milos</creatorcontrib><creatorcontrib>Milosevic-Djeric, Ana</creatorcontrib><creatorcontrib>Lazovic-Radonjic, Gordana</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><jtitle>Journal of medical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Acimovic, Milena</au><au>Vidakovic, Snezana</au><au>Milic, Natasa</au><au>Jeremic, Katarina</au><au>Markovic, Milos</au><au>Milosevic-Djeric, Ana</au><au>Lazovic-Radonjic, Gordana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis/ Survivin i vegf kao novi biomarkeri u dijagnostici endometrioze</atitle><jtitle>Journal of medical biochemistry</jtitle><date>2016-01-01</date><risdate>2016</risdate><volume>35</volume><issue>1</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><issn>1452-8266</issn><issn>1452-8258</issn><eissn>1452-8266</eissn><abstract>Background: The aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis.
Methods: This study included 40 patients undergoing laparoscopy for suspected endometriosis from January to December 2012. Preoperative levels of serum CA125, CA19-9, CEA and mRNA expression levels for survivin and VEGF were obtained. Real-time PCR was used to determine relative gene expression. A new diagnostic score was obtained by deploying the peripheral blood markers to the TVU findings. Statistical methods used were Chi-square, Fisher’s, Student’s t-test or the Mann - Whitney test.
Results: There was a statistically significant difference in serum CA125, survivin and VEGF levels in patients with endometriosis and those without endometriosis (p<0.001, p=0.025 and p=0.009, respectively). False negative TVU findings were noted in 3/13 patients (23.1%) with peritoneal endometriosis without ovaries involvement. High sensitivity (93.3%), specificity (90.0%), PPV (96.6%), NPV (81.8%) and accuracy (92.5%) were obtained for a diagnostic score based on TVU and significant peripheral blood markers (CA125, survivin and VEGF).
Conclusions: Determination of serum CA125, mRNA expression levels for survivin and VEGF along with TVU can contribute to higher accuracy of the noninvasive diagnostic tools for endometriosis.
Uvod: Cilj ovog istraživanja je da se ispita značaj određivanja koncentracija serumskih biomarkera (CA125, CA19-9, CEA i ekspresije iRNK za survivin i VEGF) zajedno sa trans- vaginalnim ultrazvučnim pregledom (TVU) prilikom dijag- nostikovanja endometrioze.
Metode: Ova studija obuhvata 40 pacijentkinja kojima je zbog sumnje|na postojanje endometrioze urađena dijagnostička laparoskopija sa patohistološkom analizom u jednogodišnjem periodu od januara 2012. do decembra 2013. Preoperativno su određivane koncentracije CA125, CA19- 9, CEA kao i nivoi ekspresije iRNK za survivin i VEGF. Real- time PCR je korišćen za određivanje relativne ekspresije gena. Određivanjem vrednosti serumskih biomarkera zajedno sa TVU dobijen je novi dijagnostički skor. Statističke metode koje su korišćene su Hi kvadratni test, Fishe- rov, Studentov t test ili Mann-Whitney test.
Rezultati: Postoji statistički značajna razlika u serumskoj koncentraciji CA125, survivina i nivoa VEGF kod pacijentkinja sa endometriozom i onih bez endometrioze (p<0,001, p=0,025 i p=0,009). Lažno negativan nalaz TVU zabeležen je kod 3/13 pacijenata (23,1%) sa perito- nealnom endometriozom. Visoka osetljivost (93,3%), specifičnost (90,0%), PPV (96,6%), NPV (81,8%) i tačnost (92,5%) postižu se određivanjem koncentracija serumskih biomarkera (CA125, survivin i VEGF) i TVU.
Zaključak: Određivanje serumskih koncentracija CA125, nivoa ekspresije iRNK za survivin i VEGF zajedno sa TVU od velikog je kliničkog značaja u neinvazivnoj dijagnostici endometrioze.</abstract><cop>Belgrade</cop><pub>De Gruyter Open</pub><doi>10.1515/jomb-2015-0005</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | CA125 Endometriosis endometrioza lapa - roscopy lapa- roskopija survivin transvaginal ultrasound transvaginalni ultrazvuk VEGE CA125 VEGF |
| title | Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis/ Survivin i vegf kao novi biomarkeri u dijagnostici endometrioze |
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