Anti-inflammatory [gamma]- and [delta]-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats
Purpose This study tested the hypothesis that γ- and δ-tocotrienols are more effective than [alpha]-tocotrienol and [alpha]-tocopherol in attenuating the signs of diet-induced metabolic syndrome in rats. Methods Five groups of rats were fed a corn starch-rich (C) diet containing 68 % carbohydrates a...
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description | Purpose This study tested the hypothesis that γ- and δ-tocotrienols are more effective than [alpha]-tocotrienol and [alpha]-tocopherol in attenuating the signs of diet-induced metabolic syndrome in rats. Methods Five groups of rats were fed a corn starch-rich (C) diet containing 68 % carbohydrates as polysaccharides, while the other five groups were fed a diet (H) high in simple carbohydrates (fructose and sucrose in food, 25 % fructose in drinking water, total 68 %) and fats (beef tallow, total 24 %) for 16 weeks. Separate groups from each diet were supplemented with either [alpha]-, γ-, δ-tocotrienol or [alpha]-tocopherol (85 mg/kg/day) for the final 8 of the 16 weeks. Results H rats developed visceral obesity, hypertension, insulin resistance, cardiovascular remodelling and fatty liver. [alpha]-Tocopherol, [alpha]-, γ- and δ-tocotrienols reduced collagen deposition and inflammatory cell infiltration in the heart. Only γ- and δ-tocotrienols improved cardiovascular function and normalised systolic blood pressure compared to H rats. Further, δ-tocotrienol improved glucose tolerance, insulin sensitivity, lipid profile and abdominal adiposity. In the liver, these interventions reduced lipid accumulation, inflammatory infiltrates and plasma liver enzyme activities. Tocotrienols were measured in heart, liver and adipose tissue showing that chronic oral dosage delivered tocotrienols to these organs despite low or no detection of tocotrienols in plasma. Conclusion In rats, δ-tocotrienol improved inflammation, heart structure and function, and liver structure and function, while γ-tocotrienol produced more modest improvements, with minimal changes with [alpha]-tocotrienol and [alpha]-tocopherol. The most important mechanism of action is likely to be reduction in organ inflammation. |
doi_str_mv | 10.1007/s00394-015-1064-1 |
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Methods Five groups of rats were fed a corn starch-rich (C) diet containing 68 % carbohydrates as polysaccharides, while the other five groups were fed a diet (H) high in simple carbohydrates (fructose and sucrose in food, 25 % fructose in drinking water, total 68 %) and fats (beef tallow, total 24 %) for 16 weeks. Separate groups from each diet were supplemented with either [alpha]-, γ-, δ-tocotrienol or [alpha]-tocopherol (85 mg/kg/day) for the final 8 of the 16 weeks. Results H rats developed visceral obesity, hypertension, insulin resistance, cardiovascular remodelling and fatty liver. [alpha]-Tocopherol, [alpha]-, γ- and δ-tocotrienols reduced collagen deposition and inflammatory cell infiltration in the heart. Only γ- and δ-tocotrienols improved cardiovascular function and normalised systolic blood pressure compared to H rats. Further, δ-tocotrienol improved glucose tolerance, insulin sensitivity, lipid profile and abdominal adiposity. In the liver, these interventions reduced lipid accumulation, inflammatory infiltrates and plasma liver enzyme activities. Tocotrienols were measured in heart, liver and adipose tissue showing that chronic oral dosage delivered tocotrienols to these organs despite low or no detection of tocotrienols in plasma. Conclusion In rats, δ-tocotrienol improved inflammation, heart structure and function, and liver structure and function, while γ-tocotrienol produced more modest improvements, with minimal changes with [alpha]-tocotrienol and [alpha]-tocopherol. The most important mechanism of action is likely to be reduction in organ inflammation.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-015-1064-1</identifier><language>eng</language><publisher>Heidelberg: Springer Nature B.V</publisher><ispartof>European journal of nutrition, 2017-02, Vol.56 (1), p.133</ispartof><rights>European Journal of Nutrition is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Wong, Weng-yew</creatorcontrib><creatorcontrib>Ward, Leigh C</creatorcontrib><creatorcontrib>Fong, Chee Wai</creatorcontrib><creatorcontrib>Yap, Wei Ney</creatorcontrib><creatorcontrib>Brown, Lindsay</creatorcontrib><title>Anti-inflammatory [gamma]- and [delta]-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats</title><title>European journal of nutrition</title><description>Purpose This study tested the hypothesis that γ- and δ-tocotrienols are more effective than [alpha]-tocotrienol and [alpha]-tocopherol in attenuating the signs of diet-induced metabolic syndrome in rats. Methods Five groups of rats were fed a corn starch-rich (C) diet containing 68 % carbohydrates as polysaccharides, while the other five groups were fed a diet (H) high in simple carbohydrates (fructose and sucrose in food, 25 % fructose in drinking water, total 68 %) and fats (beef tallow, total 24 %) for 16 weeks. Separate groups from each diet were supplemented with either [alpha]-, γ-, δ-tocotrienol or [alpha]-tocopherol (85 mg/kg/day) for the final 8 of the 16 weeks. Results H rats developed visceral obesity, hypertension, insulin resistance, cardiovascular remodelling and fatty liver. [alpha]-Tocopherol, [alpha]-, γ- and δ-tocotrienols reduced collagen deposition and inflammatory cell infiltration in the heart. Only γ- and δ-tocotrienols improved cardiovascular function and normalised systolic blood pressure compared to H rats. Further, δ-tocotrienol improved glucose tolerance, insulin sensitivity, lipid profile and abdominal adiposity. In the liver, these interventions reduced lipid accumulation, inflammatory infiltrates and plasma liver enzyme activities. Tocotrienols were measured in heart, liver and adipose tissue showing that chronic oral dosage delivered tocotrienols to these organs despite low or no detection of tocotrienols in plasma. Conclusion In rats, δ-tocotrienol improved inflammation, heart structure and function, and liver structure and function, while γ-tocotrienol produced more modest improvements, with minimal changes with [alpha]-tocotrienol and [alpha]-tocopherol. The most important mechanism of action is likely to be reduction in organ inflammation.</description><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNjc1KBDEQhIMouP48gLcGr0Y7mZmMexRRfABviyzZpEd6ySSaZAY8--KOIp491VdUFSXEhcJrhdjfFMRm3UpUnVRoWqkOxEq1jZFGq-7wj7E_Fiel7BFRN0atxOddrCw5DsGOo60pf8Dm9RtfJNjoYeMp1MXU5FLNTDGFAjy-5TQTOJs9p9kWNwWbryDwTPlnNlK1uxTYwTBFVzlF4AieqS5ffnLkIe2oEGRby5k4GmwodP6rp-Ly8eH5_kkuL-8TlbrdpynHJdqqW9Ppbq173fyv9QWHRVkb</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Wong, Weng-yew</creator><creator>Ward, Leigh C</creator><creator>Fong, Chee Wai</creator><creator>Yap, Wei Ney</creator><creator>Brown, Lindsay</creator><general>Springer Nature B.V</general><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20170201</creationdate><title>Anti-inflammatory [gamma]- and [delta]-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats</title><author>Wong, Weng-yew ; Ward, Leigh C ; Fong, Chee Wai ; Yap, Wei Ney ; Brown, Lindsay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_18652592723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Weng-yew</creatorcontrib><creatorcontrib>Ward, Leigh C</creatorcontrib><creatorcontrib>Fong, Chee Wai</creatorcontrib><creatorcontrib>Yap, Wei Ney</creatorcontrib><creatorcontrib>Brown, Lindsay</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Weng-yew</au><au>Ward, Leigh C</au><au>Fong, Chee Wai</au><au>Yap, Wei Ney</au><au>Brown, Lindsay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory [gamma]- and [delta]-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats</atitle><jtitle>European journal of nutrition</jtitle><date>2017-02-01</date><risdate>2017</risdate><volume>56</volume><issue>1</issue><spage>133</spage><pages>133-</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose This study tested the hypothesis that γ- and δ-tocotrienols are more effective than [alpha]-tocotrienol and [alpha]-tocopherol in attenuating the signs of diet-induced metabolic syndrome in rats. Methods Five groups of rats were fed a corn starch-rich (C) diet containing 68 % carbohydrates as polysaccharides, while the other five groups were fed a diet (H) high in simple carbohydrates (fructose and sucrose in food, 25 % fructose in drinking water, total 68 %) and fats (beef tallow, total 24 %) for 16 weeks. Separate groups from each diet were supplemented with either [alpha]-, γ-, δ-tocotrienol or [alpha]-tocopherol (85 mg/kg/day) for the final 8 of the 16 weeks. Results H rats developed visceral obesity, hypertension, insulin resistance, cardiovascular remodelling and fatty liver. [alpha]-Tocopherol, [alpha]-, γ- and δ-tocotrienols reduced collagen deposition and inflammatory cell infiltration in the heart. Only γ- and δ-tocotrienols improved cardiovascular function and normalised systolic blood pressure compared to H rats. Further, δ-tocotrienol improved glucose tolerance, insulin sensitivity, lipid profile and abdominal adiposity. In the liver, these interventions reduced lipid accumulation, inflammatory infiltrates and plasma liver enzyme activities. Tocotrienols were measured in heart, liver and adipose tissue showing that chronic oral dosage delivered tocotrienols to these organs despite low or no detection of tocotrienols in plasma. Conclusion In rats, δ-tocotrienol improved inflammation, heart structure and function, and liver structure and function, while γ-tocotrienol produced more modest improvements, with minimal changes with [alpha]-tocotrienol and [alpha]-tocopherol. The most important mechanism of action is likely to be reduction in organ inflammation.</abstract><cop>Heidelberg</cop><pub>Springer Nature B.V</pub><doi>10.1007/s00394-015-1064-1</doi></addata></record> |
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title | Anti-inflammatory [gamma]- and [delta]-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats |
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