Proliferative Potential of Cardiomyocytes in Hypertrophic Cardiomyopathy: Correlation with Myocardial Remodeling
Proliferating Ki-67 + cardiomyocytes were detected in the interventricular septum myocardium of adult patients with hypertrophic cardiomyopathy. In the same patients, the severity of hypertrophy and the degree of cardiomyocyte differentiation were assessed by the content of myofibrils, ultrastructur...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2016-11, Vol.162 (1), p.160-169 |
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| creator | Sukhacheva, T. V. Chudinovskikh, Yu. A. Eremeeva, M. V. Serov, R. A. Bockeria, L. A. |
| description | Proliferating Ki-67
+
cardiomyocytes were detected in the interventricular septum myocardium of adult patients with hypertrophic cardiomyopathy. In the same patients, the severity of hypertrophy and the degree of cardiomyocyte differentiation were assessed by the content of myofibrils, ultrastructural morphology, and the pattern of connexin 43-containing gap junction distribution. Adult Ki-67
+
cardiomyocytes containing sarcomeric α-actin (sarc α-act
+
) in the sarcoplasm (diameter 23.9±6.9 μ) were detected in the myocardium of patients with hypertrophic cardiomyopathy; their relative content varied from 2 to 3084 cells per 1 million cardiomyocytes. Small early differentiating Ki-67
+
/sarc α-act
+
cardiomyocytes with a thin cytoplasm layer (diameter 5.9±1.7 μ) constituted from 3 to 2262 cells per 1 million cardiomyocytes. These cells were found in the myocardium with the most pronounced structural changes: hypertrophy of cardiomyocytes with signs of their partial dedifferentiation. |
| doi_str_mv | 10.1007/s10517-016-3566-0 |
| format | Article |
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+
cardiomyocytes were detected in the interventricular septum myocardium of adult patients with hypertrophic cardiomyopathy. In the same patients, the severity of hypertrophy and the degree of cardiomyocyte differentiation were assessed by the content of myofibrils, ultrastructural morphology, and the pattern of connexin 43-containing gap junction distribution. Adult Ki-67
+
cardiomyocytes containing sarcomeric α-actin (sarc α-act
+
) in the sarcoplasm (diameter 23.9±6.9 μ) were detected in the myocardium of patients with hypertrophic cardiomyopathy; their relative content varied from 2 to 3084 cells per 1 million cardiomyocytes. Small early differentiating Ki-67
+
/sarc α-act
+
cardiomyocytes with a thin cytoplasm layer (diameter 5.9±1.7 μ) constituted from 3 to 2262 cells per 1 million cardiomyocytes. These cells were found in the myocardium with the most pronounced structural changes: hypertrophy of cardiomyocytes with signs of their partial dedifferentiation.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-016-3566-0</identifier><identifier>PMID: 27882462</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Actin ; Actins - genetics ; Actins - metabolism ; Adolescent ; Adult ; Biomedical and Life Sciences ; Biomedicine ; Cardiomyocytes ; Cardiomyopathy ; Cardiomyopathy, Hypertrophic - genetics ; Cardiomyopathy, Hypertrophic - metabolism ; Cardiomyopathy, Hypertrophic - pathology ; Cell Biology ; Cell Count ; Cell Differentiation ; Cell Proliferation ; Connexin 43 ; Connexin 43 - genetics ; Connexin 43 - metabolism ; Cytoplasm ; Female ; Gene Expression ; Heart cells ; Heart Ventricles - metabolism ; Heart Ventricles - pathology ; Heart Ventricles - ultrastructure ; Humans ; Hypertrophic cardiomyopathy ; Hypertrophy ; Internal Medicine ; Ki-67 Antigen - genetics ; Ki-67 Antigen - metabolism ; Laboratory Medicine ; Male ; Middle Aged ; Muscle proteins ; Myocardium ; Myocardium - metabolism ; Myocardium - pathology ; Myocardium - ultrastructure ; Myocytes, Cardiac - metabolism ; Myocytes, Cardiac - pathology ; Myocytes, Cardiac - ultrastructure ; Myofibrils ; Pathology ; Sarcomeres - metabolism ; Sarcomeres - pathology ; Sarcomeres - ultrastructure ; Septum ; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) ; Ventricular Remodeling</subject><ispartof>Bulletin of experimental biology and medicine, 2016-11, Vol.162 (1), p.160-169</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-1cec437ca8b95341881a4e7ea185dcdf64679c20b4268326e0074c1f39101bcb3</citedby><cites>FETCH-LOGICAL-c507t-1cec437ca8b95341881a4e7ea185dcdf64679c20b4268326e0074c1f39101bcb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-016-3566-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-016-3566-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27882462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sukhacheva, T. V.</creatorcontrib><creatorcontrib>Chudinovskikh, Yu. A.</creatorcontrib><creatorcontrib>Eremeeva, M. V.</creatorcontrib><creatorcontrib>Serov, R. A.</creatorcontrib><creatorcontrib>Bockeria, L. A.</creatorcontrib><title>Proliferative Potential of Cardiomyocytes in Hypertrophic Cardiomyopathy: Correlation with Myocardial Remodeling</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Proliferating Ki-67
+
cardiomyocytes were detected in the interventricular septum myocardium of adult patients with hypertrophic cardiomyopathy. In the same patients, the severity of hypertrophy and the degree of cardiomyocyte differentiation were assessed by the content of myofibrils, ultrastructural morphology, and the pattern of connexin 43-containing gap junction distribution. Adult Ki-67
+
cardiomyocytes containing sarcomeric α-actin (sarc α-act
+
) in the sarcoplasm (diameter 23.9±6.9 μ) were detected in the myocardium of patients with hypertrophic cardiomyopathy; their relative content varied from 2 to 3084 cells per 1 million cardiomyocytes. Small early differentiating Ki-67
+
/sarc α-act
+
cardiomyocytes with a thin cytoplasm layer (diameter 5.9±1.7 μ) constituted from 3 to 2262 cells per 1 million cardiomyocytes. These cells were found in the myocardium with the most pronounced structural changes: hypertrophy of cardiomyocytes with signs of their partial dedifferentiation.</description><subject>Actin</subject><subject>Actins - genetics</subject><subject>Actins - metabolism</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiomyocytes</subject><subject>Cardiomyopathy</subject><subject>Cardiomyopathy, Hypertrophic - genetics</subject><subject>Cardiomyopathy, Hypertrophic - metabolism</subject><subject>Cardiomyopathy, Hypertrophic - pathology</subject><subject>Cell Biology</subject><subject>Cell Count</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Connexin 43</subject><subject>Connexin 43 - genetics</subject><subject>Connexin 43 - metabolism</subject><subject>Cytoplasm</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Heart cells</subject><subject>Heart Ventricles - metabolism</subject><subject>Heart Ventricles - pathology</subject><subject>Heart Ventricles - ultrastructure</subject><subject>Humans</subject><subject>Hypertrophic cardiomyopathy</subject><subject>Hypertrophy</subject><subject>Internal Medicine</subject><subject>Ki-67 Antigen - genetics</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle proteins</subject><subject>Myocardium</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Myocardium - ultrastructure</subject><subject>Myocytes, Cardiac - metabolism</subject><subject>Myocytes, Cardiac - pathology</subject><subject>Myocytes, Cardiac - ultrastructure</subject><subject>Myofibrils</subject><subject>Pathology</subject><subject>Sarcomeres - metabolism</subject><subject>Sarcomeres - pathology</subject><subject>Sarcomeres - ultrastructure</subject><subject>Septum</subject><subject>Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)</subject><subject>Ventricular Remodeling</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kdFr1TAYxYMo7m76B_giBWFvnfnSNkl9G5e5CZMN0eeQpl9vM9qmJrlK_3tT7nQbOPIQku93Tjg5hLwDegaUio8BaAUip8DzouI8py_IBipR5JIxeEk2NEF5KaU8Isch3K1HyuE1OWJCSlZytiHzrXeD7dDraH9hdusiTtHqIXNdttW-tW5cnFkihsxO2dUyo4_ezb01D-NZx375lG2d9zgkHzdlv23ss69JuTLJ7RuOrsXBTrs35FWnh4Bv7_cT8uPzxfftVX59c_lle36dm4qKmINBUxbCaNnUVVGClKBLFKhBVq1pO15yURtGm5JxWTCOKVtpoCtqoNCYpjghHw6-s3c_9xiiunN7P6UnFUhOZS1FJR-onR5Q2alz0Wsz2mDUeVnLRFRSJOrsP1RaLY7WuAk7m-6fCE4fCXrUQ-yDG_br34SnIBxA410IHjs1eztqvyigau1YHTpWqWO1dqxo0ry_T7ZvRmz_Kf6WmgB2AEIaTTv0j6I_6_oHec6w-Q</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Sukhacheva, T. V.</creator><creator>Chudinovskikh, Yu. A.</creator><creator>Eremeeva, M. V.</creator><creator>Serov, R. A.</creator><creator>Bockeria, L. A.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20161101</creationdate><title>Proliferative Potential of Cardiomyocytes in Hypertrophic Cardiomyopathy: Correlation with Myocardial Remodeling</title><author>Sukhacheva, T. V. ; Chudinovskikh, Yu. A. ; Eremeeva, M. V. ; Serov, R. A. ; Bockeria, L. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-1cec437ca8b95341881a4e7ea185dcdf64679c20b4268326e0074c1f39101bcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Actin</topic><topic>Actins - genetics</topic><topic>Actins - metabolism</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiomyocytes</topic><topic>Cardiomyopathy</topic><topic>Cardiomyopathy, Hypertrophic - genetics</topic><topic>Cardiomyopathy, Hypertrophic - metabolism</topic><topic>Cardiomyopathy, Hypertrophic - pathology</topic><topic>Cell Biology</topic><topic>Cell Count</topic><topic>Cell Differentiation</topic><topic>Cell Proliferation</topic><topic>Connexin 43</topic><topic>Connexin 43 - genetics</topic><topic>Connexin 43 - metabolism</topic><topic>Cytoplasm</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Heart cells</topic><topic>Heart Ventricles - metabolism</topic><topic>Heart Ventricles - pathology</topic><topic>Heart Ventricles - ultrastructure</topic><topic>Humans</topic><topic>Hypertrophic cardiomyopathy</topic><topic>Hypertrophy</topic><topic>Internal Medicine</topic><topic>Ki-67 Antigen - genetics</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle proteins</topic><topic>Myocardium</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Myocardium - ultrastructure</topic><topic>Myocytes, Cardiac - metabolism</topic><topic>Myocytes, Cardiac - pathology</topic><topic>Myocytes, Cardiac - ultrastructure</topic><topic>Myofibrils</topic><topic>Pathology</topic><topic>Sarcomeres - metabolism</topic><topic>Sarcomeres - pathology</topic><topic>Sarcomeres - ultrastructure</topic><topic>Septum</topic><topic>Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sukhacheva, T. V.</creatorcontrib><creatorcontrib>Chudinovskikh, Yu. A.</creatorcontrib><creatorcontrib>Eremeeva, M. V.</creatorcontrib><creatorcontrib>Serov, R. A.</creatorcontrib><creatorcontrib>Bockeria, L. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sukhacheva, T. V.</au><au>Chudinovskikh, Yu. A.</au><au>Eremeeva, M. V.</au><au>Serov, R. A.</au><au>Bockeria, L. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proliferative Potential of Cardiomyocytes in Hypertrophic Cardiomyopathy: Correlation with Myocardial Remodeling</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>162</volume><issue>1</issue><spage>160</spage><epage>169</epage><pages>160-169</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Proliferating Ki-67
+
cardiomyocytes were detected in the interventricular septum myocardium of adult patients with hypertrophic cardiomyopathy. In the same patients, the severity of hypertrophy and the degree of cardiomyocyte differentiation were assessed by the content of myofibrils, ultrastructural morphology, and the pattern of connexin 43-containing gap junction distribution. Adult Ki-67
+
cardiomyocytes containing sarcomeric α-actin (sarc α-act
+
) in the sarcoplasm (diameter 23.9±6.9 μ) were detected in the myocardium of patients with hypertrophic cardiomyopathy; their relative content varied from 2 to 3084 cells per 1 million cardiomyocytes. Small early differentiating Ki-67
+
/sarc α-act
+
cardiomyocytes with a thin cytoplasm layer (diameter 5.9±1.7 μ) constituted from 3 to 2262 cells per 1 million cardiomyocytes. These cells were found in the myocardium with the most pronounced structural changes: hypertrophy of cardiomyocytes with signs of their partial dedifferentiation.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27882462</pmid><doi>10.1007/s10517-016-3566-0</doi><tpages>10</tpages></addata></record> |
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| ispartof | Bulletin of experimental biology and medicine, 2016-11, Vol.162 (1), p.160-169 |
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| language | eng |
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| subjects | Actin Actins - genetics Actins - metabolism Adolescent Adult Biomedical and Life Sciences Biomedicine Cardiomyocytes Cardiomyopathy Cardiomyopathy, Hypertrophic - genetics Cardiomyopathy, Hypertrophic - metabolism Cardiomyopathy, Hypertrophic - pathology Cell Biology Cell Count Cell Differentiation Cell Proliferation Connexin 43 Connexin 43 - genetics Connexin 43 - metabolism Cytoplasm Female Gene Expression Heart cells Heart Ventricles - metabolism Heart Ventricles - pathology Heart Ventricles - ultrastructure Humans Hypertrophic cardiomyopathy Hypertrophy Internal Medicine Ki-67 Antigen - genetics Ki-67 Antigen - metabolism Laboratory Medicine Male Middle Aged Muscle proteins Myocardium Myocardium - metabolism Myocardium - pathology Myocardium - ultrastructure Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Myocytes, Cardiac - ultrastructure Myofibrils Pathology Sarcomeres - metabolism Sarcomeres - pathology Sarcomeres - ultrastructure Septum Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Ventricular Remodeling |
| title | Proliferative Potential of Cardiomyocytes in Hypertrophic Cardiomyopathy: Correlation with Myocardial Remodeling |
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