Comparative evaluation of [beta]-catenin and E-cadherin expression in liquid aspiration biopsy specimens of thyroid nodules
We compared the results of gene molecular and immunocytochemical studies of [beta]-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/[bet...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2016-06, Vol.161 (2), p.288 |
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| creator | Isaeva, A.V Zima, A.P Saprina, T.V Kasoyan, K.T Popov, O.S Brynova, O.V Berezkina, I.S Vasileva, O.A Ryazantseva, N.V Shabalova, I.P Litvinova, L.S Pak, Yu.D Novitskii, V.V |
| description | We compared the results of gene molecular and immunocytochemical studies of [beta]-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/[beta]-catenin complex leading to switching from adhesion function of [beta]-catenin in nodular colloid goiter to predominantly transcriptional activity in papillary carcinoma. The results confirm the important role of disturbances in E-cadherin-[beta]-catenin interactions in the mechanisms of malignant transformation of follicular epithelium. Key Words: [beta]-catenin; E-cadherin; thyroid cancer |
| doi_str_mv | 10.1007/s10517-016-3397-z |
| format | Article |
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| subjects | Analysis Colorectal cancer Diagnosis Genes Prostate cancer Thyroid cancer |
| title | Comparative evaluation of [beta]-catenin and E-cadherin expression in liquid aspiration biopsy specimens of thyroid nodules |
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