Functional expression of G protein‐coupled receptor 30 in immature rat epididymal epithelium

The aim of this study is to investigate the functional role of G protein‐coupled receptor 30 (GPR30) in the epididymis. We found that GPR30 is expressed in the epithelium of the immature rat epididymis and is involved in chloride secretion into the caudal epididymis lumen. The short‐circuit current...

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Veröffentlicht in:	Cell biology international 2017-02, Vol.41 (2), p.134-146
Hauptverfasser:	Cao, Xiaonian, Huang, Jiehong, Zhang, Geng, Zuo, Wulin, Lan, Chongfeng, Sun, Qing, Yang, Dengliang, Gao, Dongdong, Cheng, Christopher H.K., Zhou, Wen‐Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cells, Cultured CFTR Chlorides - metabolism Cyclic AMP - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors Cystic Fibrosis Transmembrane Conductance Regulator - metabolism epididymis Epididymis - cytology Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Gene Expression Regulation - drug effects GPR30 Isc Male Microscopy, Fluorescence Motility Osmotic Pressure - drug effects Patch-Clamp Techniques Quinolines - chemistry Quinolines - pharmacology Quinolones - chemistry Quinolones - pharmacology Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Rodents sperm motility Sperm Motility - drug effects
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