A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2R Antagonists

The neuropeptide Y2 receptor (Y2R) is involved in various pathophysiological processes such as epilepsy, mood disorders, angiogenesis, and tumor growth. Therefore, the Y2R is an interesting target for drug development. A detailed understanding of the binding pocket could facilitate the development o...

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Veröffentlicht in:	ChemMedChem 2017-01, Vol.12 (1), p.75-85
Hauptverfasser:	Burkert, Kerstin, Zellmann, Tristan, Meier, René, Kaiser, Anette, Stichel, Jan, Meiler, Jens, Mittapalli, Gopi K., Roberts, Edward, Beck‐Sickinger, Annette G.
Format:	Artikel
Sprache:	eng
Schlagworte:	antagonists binding models Binding sites G protein-coupled receptors neuropeptide Y Signal transduction
Online-Zugang:	Volltext
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