A simple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature
A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature...
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| Veröffentlicht in: | Green chemistry letters and reviews 2014-07, Vol.7 (3), p.228-235 |
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| container_end_page | 235 |
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| container_issue | 3 |
| container_start_page | 228 |
| container_title | Green chemistry letters and reviews |
| container_volume | 7 |
| creator | Desai, Uday V. Kulkarni, Makarand A. Pandit, Kapil S. Kulkarni, Aparna M. Wadgaonkar, Prakash P. |
| description | A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature and avoidance of conventional work-up as well as purification procedure qualify this cost-effective protocol for "green synthesis." |
| doi_str_mv | 10.1080/17518253.2014.925144 |
| format | Article |
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| ispartof | Green chemistry letters and reviews, 2014-07, Vol.7 (3), p.228-235 |
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; Access via Taylor & Francis (Open Access Collection); Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | diethylamine Green chemistry multicomponent reactions organocatalyst pyridine-3,5-dicarbonitriles Temperature |
| title | A simple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature |
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