Neuronal NOS Activates Spinal NADPH Oxidase 2 Contributing to Central Sigma-1 Receptor-Induced Pain Hypersensitivity in Mice

We recently demonstrated that activation of spinal sigma-1 receptors (Sig-1Rs) induces pain hypersensitivity via the activation of neuronal nitric oxide synthase (nNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2). However, the potential direct interaction between nNOS-de...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2016/12/01, Vol.39(12), pp.1922-1931
Hauptverfasser:	Choi, Sheu-Ran, Kwon, Soon-Gu, Choi, Hoon-Seong, Han, Ho-Jae, Beitz, Alvin James, Lee, Jang-Hern
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CYBB protein Dorsal horn Glutamic acid receptors (ionotropic) Hot Temperature Hyperalgesia - metabolism Hypersensitivity Iron Kinases Male Membrane Glycoproteins - metabolism Mice Mice, Inbred ICR N-Methyl-D-aspartic acid receptors NAD(P)H oxidase NADPH Oxidase 2 NADPH Oxidases - metabolism NADPH-diaphorase Nerve Tissue Proteins - metabolism neuronal nitric oxide synthase nicotinamide adenine dinucleotide phosphate oxidase 2 Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type I - metabolism Nitric-oxide synthase Pain Pain - metabolism pain hypersensitivity Peroxynitrite Phosphates Phosphorylation Physical Stimulation Potentiation Protein kinase Protein kinase C Protein Kinase C - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Receptors, sigma - metabolism Rodents Sigma-1 Receptor Spinal cord Spinal Cord Dorsal Horn - metabolism Superoxide
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