Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of A[beta] and LRP1 in Hippocampus
Objectives. To explore the alterations of β-amyloid (Aβ) and low density lipoprotein receptor-related protein-1 (LRP1) in APP/PS1 mice after electroacupuncture (EA) treatment and further to explore the mechanism. Methods. Forty 6-month-old APP/PS1 mice were randomly divided into a model group and an...
Gespeichert in:
| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2016-01, Vol.2016 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | Evidence-based complementary and alternative medicine |
| container_volume | 2016 |
| creator | Wang, Xin Miao, Yanhuan Abulizi, Jiawula Li, Fu Mo, Yuping Xue, Weiguo Li, Zhigang |
| description | Objectives. To explore the alterations of β-amyloid (Aβ) and low density lipoprotein receptor-related protein-1 (LRP1) in APP/PS1 mice after electroacupuncture (EA) treatment and further to explore the mechanism. Methods. Forty 6-month-old APP/PS1 mice were randomly divided into a model group and an EA group, with twenty wild-type mice used as a normal control group. Mice in the EA group were treated with EA at GV 20 (bai huì) and bilateral KI 1 (y[obreve]ng quán) acupoints for 6 weeks. The Morris water maze was applied to assess the spatial memory in behavior. Immunohistochemistry (IHC), ELISA, Western blotting, and so forth were used to observe the expression of LRP1 and Aβ. Results. The Morris water maze test showed that, compared with the normal control group, the model group's learning and memory capabilities were significantly decreased (P |
| doi_str_mv | 10.1155/2016/7603975 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_1846088432</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A610316897</galeid><sourcerecordid>A610316897</sourcerecordid><originalsourceid>FETCH-LOGICAL-g562-2883622041e6b6ff4fc64bd83ed9ba6fa2211c5e428046f8c10025156a915af3</originalsourceid><addsrcrecordid>eNpFkF9LwzAUxYsoOKdvfoCAz3O5aZu2j2NMN9iwuD0IIiVNb0ZGm9SkFfdR_LbWP-jTuQ_n_g7nBME10FuAOJ4yCnyacBpmSXwSjCCJYBKxND39u5On8-DC-wOlLEuSZBR8rJrW2Tds0HTEKrKoUXbOCtm3vZFd75BYQ2Z5Ps23QHZOGL9HoyXZaIlEG7JtRadFTdYonNFmT4SpyAYb644kd7YUZX0kVY-ks2Tx3jr0Xg_EIWr2XGInXr4f1o85fNGWum2tFE3b-8vgTIna49WvjoPt3WI3X07WD_er-Ww92cecTYZ2IWeMRoC85EpFSvKorNIQq6wUXAnGAGSMwww04iqVMFSPIeYig1iocBzc_FCHFV579F1xsL0zQ2ABacRpmkYh-3ftRY2FNsp2TshGe1nMONAQeJol4SeMznPh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1846088432</pqid></control><display><type>article</type><title>Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of A[beta] and LRP1 in Hippocampus</title><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Wang, Xin ; Miao, Yanhuan ; Abulizi, Jiawula ; Li, Fu ; Mo, Yuping ; Xue, Weiguo ; Li, Zhigang</creator><creatorcontrib>Wang, Xin ; Miao, Yanhuan ; Abulizi, Jiawula ; Li, Fu ; Mo, Yuping ; Xue, Weiguo ; Li, Zhigang</creatorcontrib><description><![CDATA[Objectives. To explore the alterations of β-amyloid (Aβ) and low density lipoprotein receptor-related protein-1 (LRP1) in APP/PS1 mice after electroacupuncture (EA) treatment and further to explore the mechanism. Methods. Forty 6-month-old APP/PS1 mice were randomly divided into a model group and an EA group, with twenty wild-type mice used as a normal control group. Mice in the EA group were treated with EA at GV 20 (bai huì) and bilateral KI 1 (y[obreve]ng quán) acupoints for 6 weeks. The Morris water maze was applied to assess the spatial memory in behavior. Immunohistochemistry (IHC), ELISA, Western blotting, and so forth were used to observe the expression of LRP1 and Aβ. Results. The Morris water maze test showed that, compared with the normal control group, the model group's learning and memory capabilities were significantly decreased (P<0.05; P<0.01). The EA group was reversed (P<0.05; P<0.01). The hippocampal expression of Aβ in the EA group was significantly decreased compared to the model group (P<0.01). The expression of LRP1 in the model group was significantly lower than that in the normal control group (P<0.01); the expression in the EA group was significantly higher than that in the model group (P<0.01). Conclusions. EA therapy can improve the learning and memory capabilities of APP/PS1 mice. The underlying mechanism may lie in the upregulation of an Aβ transport receptor and LRP1.]]></description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2016/7603975</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Acupuncture ; Alzheimer's disease ; Behavior ; Brain ; Brain research ; Community health care ; Dementia ; Early intervention ; Genetic engineering ; Immunohistochemistry ; Laboratory animals ; Low density lipoprotein receptors ; Medical research ; Medicine ; Memory ; Older people ; Proteins ; Rodents ; Sedimentation & deposition ; Smooth muscle ; Studies ; Transgenic animals</subject><ispartof>Evidence-based complementary and alternative medicine, 2016-01, Vol.2016</ispartof><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Xin Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Miao, Yanhuan</creatorcontrib><creatorcontrib>Abulizi, Jiawula</creatorcontrib><creatorcontrib>Li, Fu</creatorcontrib><creatorcontrib>Mo, Yuping</creatorcontrib><creatorcontrib>Xue, Weiguo</creatorcontrib><creatorcontrib>Li, Zhigang</creatorcontrib><title>Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of A[beta] and LRP1 in Hippocampus</title><title>Evidence-based complementary and alternative medicine</title><description><![CDATA[Objectives. To explore the alterations of β-amyloid (Aβ) and low density lipoprotein receptor-related protein-1 (LRP1) in APP/PS1 mice after electroacupuncture (EA) treatment and further to explore the mechanism. Methods. Forty 6-month-old APP/PS1 mice were randomly divided into a model group and an EA group, with twenty wild-type mice used as a normal control group. Mice in the EA group were treated with EA at GV 20 (bai huì) and bilateral KI 1 (y[obreve]ng quán) acupoints for 6 weeks. The Morris water maze was applied to assess the spatial memory in behavior. Immunohistochemistry (IHC), ELISA, Western blotting, and so forth were used to observe the expression of LRP1 and Aβ. Results. The Morris water maze test showed that, compared with the normal control group, the model group's learning and memory capabilities were significantly decreased (P<0.05; P<0.01). The EA group was reversed (P<0.05; P<0.01). The hippocampal expression of Aβ in the EA group was significantly decreased compared to the model group (P<0.01). The expression of LRP1 in the model group was significantly lower than that in the normal control group (P<0.01); the expression in the EA group was significantly higher than that in the model group (P<0.01). Conclusions. EA therapy can improve the learning and memory capabilities of APP/PS1 mice. The underlying mechanism may lie in the upregulation of an Aβ transport receptor and LRP1.]]></description><subject>Acupuncture</subject><subject>Alzheimer's disease</subject><subject>Behavior</subject><subject>Brain</subject><subject>Brain research</subject><subject>Community health care</subject><subject>Dementia</subject><subject>Early intervention</subject><subject>Genetic engineering</subject><subject>Immunohistochemistry</subject><subject>Laboratory animals</subject><subject>Low density lipoprotein receptors</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Memory</subject><subject>Older people</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Sedimentation & deposition</subject><subject>Smooth muscle</subject><subject>Studies</subject><subject>Transgenic animals</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpFkF9LwzAUxYsoOKdvfoCAz3O5aZu2j2NMN9iwuD0IIiVNb0ZGm9SkFfdR_LbWP-jTuQ_n_g7nBME10FuAOJ4yCnyacBpmSXwSjCCJYBKxND39u5On8-DC-wOlLEuSZBR8rJrW2Tds0HTEKrKoUXbOCtm3vZFd75BYQ2Z5Ps23QHZOGL9HoyXZaIlEG7JtRadFTdYonNFmT4SpyAYb644kd7YUZX0kVY-ks2Tx3jr0Xg_EIWr2XGInXr4f1o85fNGWum2tFE3b-8vgTIna49WvjoPt3WI3X07WD_er-Ww92cecTYZ2IWeMRoC85EpFSvKorNIQq6wUXAnGAGSMwww04iqVMFSPIeYig1iocBzc_FCHFV579F1xsL0zQ2ABacRpmkYh-3ftRY2FNsp2TshGe1nMONAQeJol4SeMznPh</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Wang, Xin</creator><creator>Miao, Yanhuan</creator><creator>Abulizi, Jiawula</creator><creator>Li, Fu</creator><creator>Mo, Yuping</creator><creator>Xue, Weiguo</creator><creator>Li, Zhigang</creator><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20160101</creationdate><title>Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of A[beta] and LRP1 in Hippocampus</title><author>Wang, Xin ; Miao, Yanhuan ; Abulizi, Jiawula ; Li, Fu ; Mo, Yuping ; Xue, Weiguo ; Li, Zhigang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g562-2883622041e6b6ff4fc64bd83ed9ba6fa2211c5e428046f8c10025156a915af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acupuncture</topic><topic>Alzheimer's disease</topic><topic>Behavior</topic><topic>Brain</topic><topic>Brain research</topic><topic>Community health care</topic><topic>Dementia</topic><topic>Early intervention</topic><topic>Genetic engineering</topic><topic>Immunohistochemistry</topic><topic>Laboratory animals</topic><topic>Low density lipoprotein receptors</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Memory</topic><topic>Older people</topic><topic>Proteins</topic><topic>Rodents</topic><topic>Sedimentation & deposition</topic><topic>Smooth muscle</topic><topic>Studies</topic><topic>Transgenic animals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Miao, Yanhuan</creatorcontrib><creatorcontrib>Abulizi, Jiawula</creatorcontrib><creatorcontrib>Li, Fu</creatorcontrib><creatorcontrib>Mo, Yuping</creatorcontrib><creatorcontrib>Xue, Weiguo</creatorcontrib><creatorcontrib>Li, Zhigang</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xin</au><au>Miao, Yanhuan</au><au>Abulizi, Jiawula</au><au>Li, Fu</au><au>Mo, Yuping</au><au>Xue, Weiguo</au><au>Li, Zhigang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of A[beta] and LRP1 in Hippocampus</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract><![CDATA[Objectives. To explore the alterations of β-amyloid (Aβ) and low density lipoprotein receptor-related protein-1 (LRP1) in APP/PS1 mice after electroacupuncture (EA) treatment and further to explore the mechanism. Methods. Forty 6-month-old APP/PS1 mice were randomly divided into a model group and an EA group, with twenty wild-type mice used as a normal control group. Mice in the EA group were treated with EA at GV 20 (bai huì) and bilateral KI 1 (y[obreve]ng quán) acupoints for 6 weeks. The Morris water maze was applied to assess the spatial memory in behavior. Immunohistochemistry (IHC), ELISA, Western blotting, and so forth were used to observe the expression of LRP1 and Aβ. Results. The Morris water maze test showed that, compared with the normal control group, the model group's learning and memory capabilities were significantly decreased (P<0.05; P<0.01). The EA group was reversed (P<0.05; P<0.01). The hippocampal expression of Aβ in the EA group was significantly decreased compared to the model group (P<0.01). The expression of LRP1 in the model group was significantly lower than that in the normal control group (P<0.01); the expression in the EA group was significantly higher than that in the model group (P<0.01). Conclusions. EA therapy can improve the learning and memory capabilities of APP/PS1 mice. The underlying mechanism may lie in the upregulation of an Aβ transport receptor and LRP1.]]></abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1155/2016/7603975</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1741-427X |
| ispartof | Evidence-based complementary and alternative medicine, 2016-01, Vol.2016 |
| issn | 1741-427X 1741-4288 |
| language | eng |
| recordid | cdi_proquest_journals_1846088432 |
| source | PubMed Central Open Access; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acupuncture Alzheimer's disease Behavior Brain Brain research Community health care Dementia Early intervention Genetic engineering Immunohistochemistry Laboratory animals Low density lipoprotein receptors Medical research Medicine Memory Older people Proteins Rodents Sedimentation & deposition Smooth muscle Studies Transgenic animals |
| title | Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of A[beta] and LRP1 in Hippocampus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T21%3A52%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Improvement%20of%20Electroacupuncture%20on%20APP/PS1%20Transgenic%20Mice%20in%20Spatial%20Learning%20and%20Memory%20Probably%20due%20to%20Expression%20of%20A%5Bbeta%5D%20and%20LRP1%20in%20Hippocampus&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Wang,%20Xin&rft.date=2016-01-01&rft.volume=2016&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2016/7603975&rft_dat=%3Cgale_proqu%3EA610316897%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1846088432&rft_id=info:pmid/&rft_galeid=A610316897&rfr_iscdi=true |