A Facile and Efficient Synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens
A simple and convenient method has been developed for the synthesis of a series of 2‐(4‐substituted phenyl)‐4‐(substituted arylidene)‐1,3‐oxazol‐5‐ones (5a–j) via reactions of hippuric acid with differently substituted aromatic aldehydes (4a–j) in sodium acetate, potassium acetate, calcium acetate,...
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Veröffentlicht in: | Journal of the Chinese Chemical Society (Taipei) 2016-11, Vol.63 (11), p.909-916 |
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creator | Voosala, Christopher Kilaru, Padma Suhasini Dasari, Uday Kumar |
description | A simple and convenient method has been developed for the synthesis of a series of 2‐(4‐substituted phenyl)‐4‐(substituted arylidene)‐1,3‐oxazol‐5‐ones (5a–j) via reactions of hippuric acid with differently substituted aromatic aldehydes (4a–j) in sodium acetate, potassium acetate, calcium acetate, and ammonium acetate, respectively, which were tested for their efficiency as catalysts in both conventional and microwave‐assisted synthetic methods in presence of 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human pathogens (bacterial and fungal) and phytopathogens (fungal) and were compared with standard drugs. The results of the study are reported.
A series of 5‐(4H)‐oxazolones have been synthesized via both conventional and microwave‐assisted methods in the presence of calcium acetate and 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human and phytopathogens. |
doi_str_mv | 10.1002/jccs.201600083 |
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A series of 5‐(4H)‐oxazolones have been synthesized via both conventional and microwave‐assisted methods in the presence of calcium acetate and 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human and phytopathogens.</description><identifier>ISSN: 0009-4536</identifier><identifier>EISSN: 2192-6549</identifier><identifier>DOI: 10.1002/jccs.201600083</identifier><language>eng</language><publisher>Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA</publisher><subject>5(4H)-Oxazolones ; Calcium acetate ; Hippuric acid ; Microwave synthesis ; Phytopathogens</subject><ispartof>Journal of the Chinese Chemical Society (Taipei), 2016-11, Vol.63 (11), p.909-916</ispartof><rights>2016 The Chemical Society Located in Taipei & Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3923-4c1cea233fa7dcc4d5f76ecc5ea74f1cc2cfc487a4c0c10a0526d3f36c5b51ce3</citedby><cites>FETCH-LOGICAL-c3923-4c1cea233fa7dcc4d5f76ecc5ea74f1cc2cfc487a4c0c10a0526d3f36c5b51ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjccs.201600083$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjccs.201600083$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Voosala, Christopher</creatorcontrib><creatorcontrib>Kilaru, Padma Suhasini</creatorcontrib><creatorcontrib>Dasari, Uday Kumar</creatorcontrib><title>A Facile and Efficient Synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens</title><title>Journal of the Chinese Chemical Society (Taipei)</title><addtitle>Journal of the Chinese Chemical Society</addtitle><description>A simple and convenient method has been developed for the synthesis of a series of 2‐(4‐substituted phenyl)‐4‐(substituted arylidene)‐1,3‐oxazol‐5‐ones (5a–j) via reactions of hippuric acid with differently substituted aromatic aldehydes (4a–j) in sodium acetate, potassium acetate, calcium acetate, and ammonium acetate, respectively, which were tested for their efficiency as catalysts in both conventional and microwave‐assisted synthetic methods in presence of 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human pathogens (bacterial and fungal) and phytopathogens (fungal) and were compared with standard drugs. The results of the study are reported.
A series of 5‐(4H)‐oxazolones have been synthesized via both conventional and microwave‐assisted methods in the presence of calcium acetate and 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human and phytopathogens.</description><subject>5(4H)-Oxazolones</subject><subject>Calcium acetate</subject><subject>Hippuric acid</subject><subject>Microwave synthesis</subject><subject>Phytopathogens</subject><issn>0009-4536</issn><issn>2192-6549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkE1vEzEQhi0EEqFw5WyJCxwcvP7YzR6jkDRUVahoEdwsd3bcddjYYe1Atz-E38u2QRU3TiON3ucdzUPI64JPC87F-y1AmgpelJzzmXxCJqKoBSu1qp-SybirmdKyfE5epLTlXEmh6wn5PacrC75DakNDl8558BgyvRxCbjH5RKOjis37ofMNBmSC7VsMQ8f0W7V-x-KtvYtdDJgeCq5a9D2dh-x3Hvp47W1Hlz9td7DZx0DtjfUhje3YIWRs6Pqws-GBvGiHHPc2t_EGQ3pJnjnbJXz1d56QL6vl1WLNzj-dflzMzxnIWkimoAC0QkpnqwZANdpVJQJotJVyBYAAB2pWWQUcCm65FmUjnSxBX-sRlSfkzbF338cfB0zZbOOhD-NJU8yU5rzSpR5T02NqfCmlHp3Z935n-8EU3Ny7N_fuzaP7EaiPwK_R7PCftDlbLC7_ZdmR9Snj7SNr---mrGSlzdfNqdnUHz6v-MXGfJN_ADmQmd4</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Voosala, Christopher</creator><creator>Kilaru, Padma Suhasini</creator><creator>Dasari, Uday Kumar</creator><general>Wiley-VCH Verlag GmbH & Co. KGaA</general><general>Wiley‐VCH Verlag GmbH & Co. KGaA</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201611</creationdate><title>A Facile and Efficient Synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens</title><author>Voosala, Christopher ; Kilaru, Padma Suhasini ; Dasari, Uday Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3923-4c1cea233fa7dcc4d5f76ecc5ea74f1cc2cfc487a4c0c10a0526d3f36c5b51ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>5(4H)-Oxazolones</topic><topic>Calcium acetate</topic><topic>Hippuric acid</topic><topic>Microwave synthesis</topic><topic>Phytopathogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voosala, Christopher</creatorcontrib><creatorcontrib>Kilaru, Padma Suhasini</creatorcontrib><creatorcontrib>Dasari, Uday Kumar</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Journal of the Chinese Chemical Society (Taipei)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voosala, Christopher</au><au>Kilaru, Padma Suhasini</au><au>Dasari, Uday Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Facile and Efficient Synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens</atitle><jtitle>Journal of the Chinese Chemical Society (Taipei)</jtitle><addtitle>Journal of the Chinese Chemical Society</addtitle><date>2016-11</date><risdate>2016</risdate><volume>63</volume><issue>11</issue><spage>909</spage><epage>916</epage><pages>909-916</pages><issn>0009-4536</issn><eissn>2192-6549</eissn><abstract>A simple and convenient method has been developed for the synthesis of a series of 2‐(4‐substituted phenyl)‐4‐(substituted arylidene)‐1,3‐oxazol‐5‐ones (5a–j) via reactions of hippuric acid with differently substituted aromatic aldehydes (4a–j) in sodium acetate, potassium acetate, calcium acetate, and ammonium acetate, respectively, which were tested for their efficiency as catalysts in both conventional and microwave‐assisted synthetic methods in presence of 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human pathogens (bacterial and fungal) and phytopathogens (fungal) and were compared with standard drugs. The results of the study are reported.
A series of 5‐(4H)‐oxazolones have been synthesized via both conventional and microwave‐assisted methods in the presence of calcium acetate and 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human and phytopathogens.</abstract><cop>Weinheim</cop><pub>Wiley-VCH Verlag GmbH & Co. KGaA</pub><doi>10.1002/jccs.201600083</doi><tpages>8</tpages></addata></record> |
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subjects | 5(4H)-Oxazolones Calcium acetate Hippuric acid Microwave synthesis Phytopathogens |
title | A Facile and Efficient Synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens |
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