A Facile and Efficient Synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens

A simple and convenient method has been developed for the synthesis of a series of 2‐(4‐substituted phenyl)‐4‐(substituted arylidene)‐1,3‐oxazol‐5‐ones (5a–j) via reactions of hippuric acid with differently substituted aromatic aldehydes (4a–j) in sodium acetate, potassium acetate, calcium acetate,...

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Veröffentlicht in:Journal of the Chinese Chemical Society (Taipei) 2016-11, Vol.63 (11), p.909-916
Hauptverfasser: Voosala, Christopher, Kilaru, Padma Suhasini, Dasari, Uday Kumar
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container_title Journal of the Chinese Chemical Society (Taipei)
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creator Voosala, Christopher
Kilaru, Padma Suhasini
Dasari, Uday Kumar
description A simple and convenient method has been developed for the synthesis of a series of 2‐(4‐substituted phenyl)‐4‐(substituted arylidene)‐1,3‐oxazol‐5‐ones (5a–j) via reactions of hippuric acid with differently substituted aromatic aldehydes (4a–j) in sodium acetate, potassium acetate, calcium acetate, and ammonium acetate, respectively, which were tested for their efficiency as catalysts in both conventional and microwave‐assisted synthetic methods in presence of 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human pathogens (bacterial and fungal) and phytopathogens (fungal) and were compared with standard drugs. The results of the study are reported. A series of 5‐(4H)‐oxazolones have been synthesized via both conventional and microwave‐assisted methods in the presence of calcium acetate and 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human and phytopathogens.
doi_str_mv 10.1002/jccs.201600083
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subjects 5(4H)-Oxazolones
Calcium acetate
Hippuric acid
Microwave synthesis
Phytopathogens
title A Facile and Efficient Synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens
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