Antinociceptive and Anti‐Inflammatory Effects of Ketamine and the Relationship to Its Antidepressant Action and GSK3 Inhibition

Ketamine (KET), a NMDA antagonist, exerts an antidepressant effect at subanaesthetic doses and possesses analgesic and anti‐inflammatory activities. We evaluated the involvement of KET antinociceptive and anti‐inflammatory effects with its antidepressant action. Male Swiss mice were subjected to for...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2016-12, Vol.119 (6), p.562-573
Hauptverfasser:	Vale, Eduardo Mulato, Xavier, Cecília Coelho, Nogueira, Brenda Gomes, Campos, Bruna Caldas, Aquino, Pedro Everson Alexandre, Costa, Roberta Oliveira, Leal, Luzia Kalyne Almeida Moreira, Vasconcelos, Silvânia Maria Mendes, Neves, Kelly Rose Tavares, Barros Viana, Glauce Socorro
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - administration & dosage Analgesics - therapeutic use Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antidepressive Agents - administration & dosage Antidepressive Agents - therapeutic use Behavior, Animal - drug effects Cyclooxygenase 2 - chemistry Cyclooxygenase 2 - metabolism Depression - metabolism Depression - pathology Depression - prevention & control Disease Models, Animal Dose-Response Relationship, Drug Drug Therapy, Combination Edema Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - therapeutic use Glycogen Synthase Kinase 3 beta - antagonists & inhibitors Glycogen Synthase Kinase 3 beta - metabolism Immunohistochemistry Ketamine - administration & dosage Ketamine - therapeutic use Lithium - therapeutic use Male Mice Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - metabolism Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - therapeutic use Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Rodents Subcutaneous Tissue - drug effects Subcutaneous Tissue - metabolism Subcutaneous Tissue - pathology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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