An effective strategy to prevent allopurinol-induced hypersensitivity by HLA typing

Purpose: This study was conducted to evaluate the usefulness of human leukocyte antigen (HLA) typing in preventing allopurinol-induced severe cutaneous adverse reactions (SCARs) through the application of an allopurinol tolerance induction protocol or prescription of other alternative medications in...

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Veröffentlicht in:	Genetics in medicine 2015-10, Vol.17 (10), p.807-814
Hauptverfasser:	Jung, Jae-Woo, Kim, Dong-Ki, Park, Heung-Woo, Oh, Kook-Hwan, Joo, Kwon-Wook, Kim, Yon-Su, Ahn, Curie, Lee, Kyung Wha, Cho, Sang-Heon, Min, Kyung-Up, Kang, Hye-Ryun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/1512 692/699/1585 692/699/249 692/700/565/1436/434 Adult Aged Alleles Allopurinol - administration & dosage Allopurinol - adverse effects Biomedicine Desensitization, Immunologic Drug Hypersensitivity - diagnosis Drug Hypersensitivity - epidemiology Drug Hypersensitivity - genetics Drug Hypersensitivity - immunology Drug Hypersensitivity - prevention & control Female Histocompatibility Antigens - genetics Histocompatibility Antigens - immunology Histocompatibility Testing HLA-B Antigens - genetics HLA-B Antigens - immunology Human Genetics Humans Immune Tolerance Incidence Laboratory Medicine Male Middle Aged original-research-article Risk Factors
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