Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study

The mechanism causing gastrointestinal intolerance to metformin treatment is unknown. We have previously shown that reduced-function alleles of organic cation transporter 1 (OCT1) are associated with increased intolerance to metformin. Considering recent findings that serotonin reuptake transporter...

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Veröffentlicht in:	Diabetes care 2016-11, Vol.39 (11), p.1896-1901
Hauptverfasser:	Dujic, Tanja, Zhou, Kaixin, Tavendale, Roger, Palmer, Colin N A, Pearson, Ewan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Diabetes Diabetes Mellitus, Type 2 - drug therapy Female Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - genetics Genotype Genotype & phenotype Humans Hypoglycemic Agents - adverse effects Male Metformin - adverse effects Middle Aged Octamer Transcription Factor-1 - genetics Pharmaceuticals Polymorphism Polymorphism, Genetic Serotonin Serotonin Plasma Membrane Transport Proteins - genetics Side effects
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