Evaluation of the Antioxidant Activity of Copper(II) Complexes containing Tris-(hydroxymethyl)aminomethane (TRIS) Units

Evaluation of the Antioxidant Activity of Copper(II) Complexes containing Tris-(hydroxymethyl)aminomethane (TRIS) Units

The structural analysis and the SOD‐like activity of CuII complexes [(Cu)(C16H18N3O5)]ClO4 (1) and [(Cu)4(C36H52N8O12)] (2) are described with ligands obtained from the condensation of picolinaldehyde and 2‐formylpyrrole with tris(hydroxymethyl)aminomethane (TRIS). Finally, complex 1 catalyzes the d...

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Veröffentlicht in:Zeitschrift für anorganische und allgemeine Chemie (1950) 2016-10, Vol.642 (21), p.1192-1197
Hauptverfasser: Canabarro, Cibele M., Ceolin, Joice, Siqueira, Josiéli D., Iglesias, Bernardo A., Manzoni de Oliveira, Gelson, Back, Davi F., Campos, Patrick T.
Format: Artikel
Sprache:eng
Schlagworte:
Copper
Schiff bases
Schiff bases
Copper
Superoxide dismutase
SOD mimics
SOD mimics
Superoxide dismutase
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Zusammenfassung:The structural analysis and the SOD‐like activity of CuII complexes [(Cu)(C16H18N3O5)]ClO4 (1) and [(Cu)4(C36H52N8O12)] (2) are described with ligands obtained from the condensation of picolinaldehyde and 2‐formylpyrrole with tris(hydroxymethyl)aminomethane (TRIS). Finally, complex 1 catalyzes the dismutation of superoxide efficiently with IC50 values in the range of 0.43 micromolar solution, evaluated through the inhibition of the photoreduction of nitro blue tetrazolium (NBT) (superoxide dismutase assay).
ISSN:0044-2313
1521-3749
DOI:10.1002/zaac.201600214