Wnt/[Beta]-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells

In both mice and humans, pluripotent stem cells (PSCs) exist in at least two distinct states of pluripotency, known as the naive and primed states. Our understanding of the intrinsic and extrinsic factors that enable PSCs to self-renew and to transition between different pluripotent states is import...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-10, Vol.113 (42), p.E6382
Hauptverfasser:	Xu, Zhuojin, Robitaille, Aaron M, Berndt, Jason D, Davidson, Kathryn C, Fischer, Karin A, Mathieu, Julie, Potter, Jennifer C, Ruohola-Baker, Hannele, Moon, Randall T
Format:	Artikel
Sprache:	eng
Schlagworte:	Embryos Proteins Signal transduction Stem cells
Online-Zugang:	Volltext
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