Activation of [sigma]1 and [sigma]2 receptors by afobazole increases glial cell survival and prevents glial cell activation and nitrosative stress after ischemic stroke

Activation of sigma receptors at delayed time points has been shown to decrease injury following ischemic stroke. The mixed σ1/σ2 receptor agonist, 5-ethoxy-2-[2-(morpholino)-ethylthio]benzimidazole (afobazole), provides superior long-term outcomes compared to other σ ligands in the rat middle cereb...

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Veröffentlicht in:	Journal of neurochemistry 2016-11, Vol.139 (3), p.497
Hauptverfasser:	Katnik, Christopher, Garcia, Angela, Behensky, Adam A, Yasny, Ilya E, Shuster, Alex M, Seredenin, Sergei B, Petrov, Andrey V, Cuevas, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Gangrene Neurochemistry Pharmacology Rodents Stroke Tumor necrosis factor-TNF
Online-Zugang:	Volltext
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