Application of autologous platelet-rich plasma (PRP) onwound healing after caesarean section in high-risk patients
Background : Platelet-rich plasma (PRP) is ahumanplasma product enriched by platelets, growth factors, and fibrinogen with high hemostatic and healing properties. Objectives : The aim of this study was to evaluate the effect of autologous PRP on wound healing in high-risk women undergoing cesarean s...
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| Veröffentlicht in: | Iranian red crescent medical journal 2016-07, Vol.18 (7), p.1-8 |
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| creator | Heidary, Somaye Sadat Pirjani, Reihaneh Rezaei, Negar Sepidarkish, Mahdi Tehranian, Afsaneh IsfIhani Mihr, Baharih |
| description | Background : Platelet-rich plasma (PRP) is ahumanplasma product enriched by platelets, growth factors, and fibrinogen with high
hemostatic and healing properties.
Objectives : The aim of this study was to evaluate the effect of autologous PRP on wound healing in high-risk women undergoing
cesarean sections.
Patients and Methods : In this balanced, randomized, and controlled trial, 140 patients were admitted to Arash women’s hospital,
Tehran, Iran from May of 2013 to November of 2014 for elective cesarean surgery. The patients were randomly assigned into two
groups. The intervention group received PRP after surgery, whereas the control group received the usual care. All patients were
evaluated at baseline, five days, and eight weeks after the cesarean section. The primary endpoint used the REEDA scale for assessing
the changes in wound healing. The secondary outcome measures used were the Vancouver scar scale (VSS) and the visual analog
scale (VAS). All scale scores were analyzed using a repeated measures test for variance.
Results : At the end of study, the PRP group showed a greater reduction in the edema ecchymosed discharge approximation (REEDA)
score compared to the control group (85.5 % reduction in the PRP group; 72 % in the control group) (P < 0.001). Compared with the
control group, the PRP group had a significantly greater reduction in the VANscore, beginning on the fifth day after the cesarean section
(-0.7, 38 % reduction in PRP group; -0.8, 33 % in control group) (P < 0.001), and this trend was stable at the end of the eighth week
(-0.6, 54 % reduction in PRP group ; -0.3, 18 % in control group). Furthermore, patients treated with PRP experienced a 93 % reduction
in the VAS score at the end of follow-up, but the control group only observed a 79 % reduction (P < 0.001).
Conclusions : It seems that applying PRP is an effective therapeutic approach for wound healing, and faster wound healing is expected
due to the presence of more platelets and growth factors. |
| doi_str_mv | 10.5812/ircmj.34449. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_emare</sourceid><recordid>TN_cdi_proquest_journals_1830836571</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4223018611</sourcerecordid><originalsourceid>FETCH-LOGICAL-e501-755a28c0f340e143e84033b3625b82812839cab6ff9f752e2303a69443862d183</originalsourceid><addsrcrecordid>eNo9j81LAzEQxYMoWKs3r0LAix625nM3eyziFxQs0vuSbifd1G2yJlnE_95oxdO84T1-bwahS0pmUlF2Z0O73824EKKeHaEJI5UoaDaO_zURp-gsxh0hsi4Zn6AwH4betjpZ77A3WI_J937rx4iHXifoIRXBtt3PFvca3yzflrfYu08_ug3uQPfWbbE2CQJuNUQdQDscof0FWoc7u-0yIb7jIZeAS_EcnRjdR7j4m1O0enxY3T8Xi9enl_v5ogBJaFFJqZlqieGCABUclCCcr3nJ5Fqx_JTidavXpTG1qSQDxgnXZS0EVyXbUMWn6PqAHYL_GCGmZufH4HJjk12ieCkrmlNXhxTs8-lGN0OwWX01FaFKKv4Ne0tlrg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1830836571</pqid></control><display><type>article</type><title>Application of autologous platelet-rich plasma (PRP) onwound healing after caesarean section in high-risk patients</title><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Heidary, Somaye Sadat ; Pirjani, Reihaneh ; Rezaei, Negar ; Sepidarkish, Mahdi ; Tehranian, Afsaneh ; IsfIhani Mihr, Baharih</creator><creatorcontrib>Heidary, Somaye Sadat ; Pirjani, Reihaneh ; Rezaei, Negar ; Sepidarkish, Mahdi ; Tehranian, Afsaneh ; IsfIhani Mihr, Baharih</creatorcontrib><description>Background : Platelet-rich plasma (PRP) is ahumanplasma product enriched by platelets, growth factors, and fibrinogen with high
hemostatic and healing properties.
Objectives : The aim of this study was to evaluate the effect of autologous PRP on wound healing in high-risk women undergoing
cesarean sections.
Patients and Methods : In this balanced, randomized, and controlled trial, 140 patients were admitted to Arash women’s hospital,
Tehran, Iran from May of 2013 to November of 2014 for elective cesarean surgery. The patients were randomly assigned into two
groups. The intervention group received PRP after surgery, whereas the control group received the usual care. All patients were
evaluated at baseline, five days, and eight weeks after the cesarean section. The primary endpoint used the REEDA scale for assessing
the changes in wound healing. The secondary outcome measures used were the Vancouver scar scale (VSS) and the visual analog
scale (VAS). All scale scores were analyzed using a repeated measures test for variance.
Results : At the end of study, the PRP group showed a greater reduction in the edema ecchymosed discharge approximation (REEDA)
score compared to the control group (85.5 % reduction in the PRP group; 72 % in the control group) (P < 0.001). Compared with the
control group, the PRP group had a significantly greater reduction in the VANscore, beginning on the fifth day after the cesarean section
(-0.7, 38 % reduction in PRP group; -0.8, 33 % in control group) (P < 0.001), and this trend was stable at the end of the eighth week
(-0.6, 54 % reduction in PRP group ; -0.3, 18 % in control group). Furthermore, patients treated with PRP experienced a 93 % reduction
in the VAS score at the end of follow-up, but the control group only observed a 79 % reduction (P < 0.001).
Conclusions : It seems that applying PRP is an effective therapeutic approach for wound healing, and faster wound healing is expected
due to the presence of more platelets and growth factors.</description><identifier>ISSN: 2074-1804</identifier><identifier>EISSN: 2074-1812</identifier><identifier>DOI: 10.5812/ircmj.34449.</identifier><language>eng</language><publisher>Dubai, United Arab Emirates: Iranian Hospital</publisher><ispartof>Iranian red crescent medical journal, 2016-07, Vol.18 (7), p.1-8</ispartof><rights>Copyright Iranian Hospital Dubai Jul 2016</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Heidary, Somaye Sadat</creatorcontrib><creatorcontrib>Pirjani, Reihaneh</creatorcontrib><creatorcontrib>Rezaei, Negar</creatorcontrib><creatorcontrib>Sepidarkish, Mahdi</creatorcontrib><creatorcontrib>Tehranian, Afsaneh</creatorcontrib><creatorcontrib>IsfIhani Mihr, Baharih</creatorcontrib><title>Application of autologous platelet-rich plasma (PRP) onwound healing after caesarean section in high-risk patients</title><title>Iranian red crescent medical journal</title><description>Background : Platelet-rich plasma (PRP) is ahumanplasma product enriched by platelets, growth factors, and fibrinogen with high
hemostatic and healing properties.
Objectives : The aim of this study was to evaluate the effect of autologous PRP on wound healing in high-risk women undergoing
cesarean sections.
Patients and Methods : In this balanced, randomized, and controlled trial, 140 patients were admitted to Arash women’s hospital,
Tehran, Iran from May of 2013 to November of 2014 for elective cesarean surgery. The patients were randomly assigned into two
groups. The intervention group received PRP after surgery, whereas the control group received the usual care. All patients were
evaluated at baseline, five days, and eight weeks after the cesarean section. The primary endpoint used the REEDA scale for assessing
the changes in wound healing. The secondary outcome measures used were the Vancouver scar scale (VSS) and the visual analog
scale (VAS). All scale scores were analyzed using a repeated measures test for variance.
Results : At the end of study, the PRP group showed a greater reduction in the edema ecchymosed discharge approximation (REEDA)
score compared to the control group (85.5 % reduction in the PRP group; 72 % in the control group) (P < 0.001). Compared with the
control group, the PRP group had a significantly greater reduction in the VANscore, beginning on the fifth day after the cesarean section
(-0.7, 38 % reduction in PRP group; -0.8, 33 % in control group) (P < 0.001), and this trend was stable at the end of the eighth week
(-0.6, 54 % reduction in PRP group ; -0.3, 18 % in control group). Furthermore, patients treated with PRP experienced a 93 % reduction
in the VAS score at the end of follow-up, but the control group only observed a 79 % reduction (P < 0.001).
Conclusions : It seems that applying PRP is an effective therapeutic approach for wound healing, and faster wound healing is expected
due to the presence of more platelets and growth factors.</description><issn>2074-1804</issn><issn>2074-1812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNo9j81LAzEQxYMoWKs3r0LAix625nM3eyziFxQs0vuSbifd1G2yJlnE_95oxdO84T1-bwahS0pmUlF2Z0O73824EKKeHaEJI5UoaDaO_zURp-gsxh0hsi4Zn6AwH4betjpZ77A3WI_J937rx4iHXifoIRXBtt3PFvca3yzflrfYu08_ug3uQPfWbbE2CQJuNUQdQDscof0FWoc7u-0yIb7jIZeAS_EcnRjdR7j4m1O0enxY3T8Xi9enl_v5ogBJaFFJqZlqieGCABUclCCcr3nJ5Fqx_JTidavXpTG1qSQDxgnXZS0EVyXbUMWn6PqAHYL_GCGmZufH4HJjk12ieCkrmlNXhxTs8-lGN0OwWX01FaFKKv4Ne0tlrg</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Heidary, Somaye Sadat</creator><creator>Pirjani, Reihaneh</creator><creator>Rezaei, Negar</creator><creator>Sepidarkish, Mahdi</creator><creator>Tehranian, Afsaneh</creator><creator>IsfIhani Mihr, Baharih</creator><general>Iranian Hospital</general><general>Zamen Salamati Publishing</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20160701</creationdate><title>Application of autologous platelet-rich plasma (PRP) onwound healing after caesarean section in high-risk patients</title><author>Heidary, Somaye Sadat ; Pirjani, Reihaneh ; Rezaei, Negar ; Sepidarkish, Mahdi ; Tehranian, Afsaneh ; IsfIhani Mihr, Baharih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e501-755a28c0f340e143e84033b3625b82812839cab6ff9f752e2303a69443862d183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Heidary, Somaye Sadat</creatorcontrib><creatorcontrib>Pirjani, Reihaneh</creatorcontrib><creatorcontrib>Rezaei, Negar</creatorcontrib><creatorcontrib>Sepidarkish, Mahdi</creatorcontrib><creatorcontrib>Tehranian, Afsaneh</creatorcontrib><creatorcontrib>IsfIhani Mihr, Baharih</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Iranian red crescent medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heidary, Somaye Sadat</au><au>Pirjani, Reihaneh</au><au>Rezaei, Negar</au><au>Sepidarkish, Mahdi</au><au>Tehranian, Afsaneh</au><au>IsfIhani Mihr, Baharih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of autologous platelet-rich plasma (PRP) onwound healing after caesarean section in high-risk patients</atitle><jtitle>Iranian red crescent medical journal</jtitle><date>2016-07-01</date><risdate>2016</risdate><volume>18</volume><issue>7</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2074-1804</issn><eissn>2074-1812</eissn><abstract>Background : Platelet-rich plasma (PRP) is ahumanplasma product enriched by platelets, growth factors, and fibrinogen with high
hemostatic and healing properties.
Objectives : The aim of this study was to evaluate the effect of autologous PRP on wound healing in high-risk women undergoing
cesarean sections.
Patients and Methods : In this balanced, randomized, and controlled trial, 140 patients were admitted to Arash women’s hospital,
Tehran, Iran from May of 2013 to November of 2014 for elective cesarean surgery. The patients were randomly assigned into two
groups. The intervention group received PRP after surgery, whereas the control group received the usual care. All patients were
evaluated at baseline, five days, and eight weeks after the cesarean section. The primary endpoint used the REEDA scale for assessing
the changes in wound healing. The secondary outcome measures used were the Vancouver scar scale (VSS) and the visual analog
scale (VAS). All scale scores were analyzed using a repeated measures test for variance.
Results : At the end of study, the PRP group showed a greater reduction in the edema ecchymosed discharge approximation (REEDA)
score compared to the control group (85.5 % reduction in the PRP group; 72 % in the control group) (P < 0.001). Compared with the
control group, the PRP group had a significantly greater reduction in the VANscore, beginning on the fifth day after the cesarean section
(-0.7, 38 % reduction in PRP group; -0.8, 33 % in control group) (P < 0.001), and this trend was stable at the end of the eighth week
(-0.6, 54 % reduction in PRP group ; -0.3, 18 % in control group). Furthermore, patients treated with PRP experienced a 93 % reduction
in the VAS score at the end of follow-up, but the control group only observed a 79 % reduction (P < 0.001).
Conclusions : It seems that applying PRP is an effective therapeutic approach for wound healing, and faster wound healing is expected
due to the presence of more platelets and growth factors.</abstract><cop>Dubai, United Arab Emirates</cop><pub>Iranian Hospital</pub><doi>10.5812/ircmj.34449.</doi><tpages>8</tpages></addata></record> |
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| title | Application of autologous platelet-rich plasma (PRP) onwound healing after caesarean section in high-risk patients |
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