222 Brain Volumetry in Infants with Congenital Heart Disease: pre- and Post-Surgery Assessments Compared to Healthy Controls
Background and aims MRI studies in neonates with congenital heart disease (CHD) have demonstrated delayed brain maturation and mostly focal brain injury. To better define the distribution of cerebral injuries and regional brain growth in neonates with CHD, we compared volumetric measures from pre- a...
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| Veröffentlicht in: | Archives of disease in childhood 2012-10, Vol.97 (Suppl 2), p.A64-A64 |
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| creator | Rhein, M von Buchmann, A Drexel, C Hagmann, C Batinic, K Bertholdt, S Bernet, V Knirsch, W Latal, B |
| description | Background and aims MRI studies in neonates with congenital heart disease (CHD) have demonstrated delayed brain maturation and mostly focal brain injury. To better define the distribution of cerebral injuries and regional brain growth in neonates with CHD, we compared volumetric measures from pre- and postoperative MRI of patients to healthy neonates. Methods Cerebral MRIs of 32 term-born CHD patients, scanned before and after heart surgery (mean age: 6.8 days and 26.8 days, respectively), were manually segmented to measure volumes of total, grey and white matter and of selected brain regions. Results were compared with MRIs of 17 healthy term born neonates (mean age: 23.5 days). Results Between pre- and postoperative MRI, patients showed significant brain growth, especially in the cortical grey matter (0.25%/day), cerebellum (0.20%/day), and deep gray matter structures (0.10–0.15%/day, all p |
| doi_str_mv | 10.1136/archdischild-2012-302724.0222 |
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To better define the distribution of cerebral injuries and regional brain growth in neonates with CHD, we compared volumetric measures from pre- and postoperative MRI of patients to healthy neonates. Methods Cerebral MRIs of 32 term-born CHD patients, scanned before and after heart surgery (mean age: 6.8 days and 26.8 days, respectively), were manually segmented to measure volumes of total, grey and white matter and of selected brain regions. Results were compared with MRIs of 17 healthy term born neonates (mean age: 23.5 days). Results Between pre- and postoperative MRI, patients showed significant brain growth, especially in the cortical grey matter (0.25%/day), cerebellum (0.20%/day), and deep gray matter structures (0.10–0.15%/day, all p<0.004). Volume increase of the white matter was 0.05–0.06%/day (left/right; p=0.017/0.003); increase of total brain volume was 0.14%/day (p<0.001). Compared to healthy controls, the size of all brain structures (except ventricles and right amygdala) was significantly reduced postoperatively. Largest differences were found in deep gray matter structures (13.8–16.8%, p=0.05-< 0.001), cortical grey (12.1%, p=0.01) and white matter (11.8%, p<0.001). Total brain volumes were reduced by 11.3% (p<0.001). Conclusions In neonates with CHD, significant differences of white and deep grey matter volumes were found postoperatively. Brain growth was high, with notable regional differences. Our results contribute to the knowledge on the timing of cerebral injury in neonates with CHD.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/archdischild-2012-302724.0222</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Brain ; Cardiovascular diseases ; Control Groups ; Neonates ; Patients</subject><ispartof>Archives of disease in childhood, 2012-10, Vol.97 (Suppl 2), p.A64-A64</ispartof><rights>2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2012 (c) 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://adc.bmj.com/content/97/Suppl_2/A64.2.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://adc.bmj.com/content/97/Suppl_2/A64.2.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77342,77373</link.rule.ids></links><search><creatorcontrib>Rhein, M von</creatorcontrib><creatorcontrib>Buchmann, A</creatorcontrib><creatorcontrib>Drexel, C</creatorcontrib><creatorcontrib>Hagmann, C</creatorcontrib><creatorcontrib>Batinic, K</creatorcontrib><creatorcontrib>Bertholdt, S</creatorcontrib><creatorcontrib>Bernet, V</creatorcontrib><creatorcontrib>Knirsch, W</creatorcontrib><creatorcontrib>Latal, B</creatorcontrib><creatorcontrib>Brain Research Heart and Group</creatorcontrib><title>222 Brain Volumetry in Infants with Congenital Heart Disease: pre- and Post-Surgery Assessments Compared to Healthy Controls</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Background and aims MRI studies in neonates with congenital heart disease (CHD) have demonstrated delayed brain maturation and mostly focal brain injury. To better define the distribution of cerebral injuries and regional brain growth in neonates with CHD, we compared volumetric measures from pre- and postoperative MRI of patients to healthy neonates. Methods Cerebral MRIs of 32 term-born CHD patients, scanned before and after heart surgery (mean age: 6.8 days and 26.8 days, respectively), were manually segmented to measure volumes of total, grey and white matter and of selected brain regions. Results were compared with MRIs of 17 healthy term born neonates (mean age: 23.5 days). Results Between pre- and postoperative MRI, patients showed significant brain growth, especially in the cortical grey matter (0.25%/day), cerebellum (0.20%/day), and deep gray matter structures (0.10–0.15%/day, all p<0.004). Volume increase of the white matter was 0.05–0.06%/day (left/right; p=0.017/0.003); increase of total brain volume was 0.14%/day (p<0.001). Compared to healthy controls, the size of all brain structures (except ventricles and right amygdala) was significantly reduced postoperatively. Largest differences were found in deep gray matter structures (13.8–16.8%, p=0.05-< 0.001), cortical grey (12.1%, p=0.01) and white matter (11.8%, p<0.001). Total brain volumes were reduced by 11.3% (p<0.001). Conclusions In neonates with CHD, significant differences of white and deep grey matter volumes were found postoperatively. Brain growth was high, with notable regional differences. Our results contribute to the knowledge on the timing of cerebral injury in neonates with CHD.</description><subject>Brain</subject><subject>Cardiovascular diseases</subject><subject>Control Groups</subject><subject>Neonates</subject><subject>Patients</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqVkF1rFDEUhoMouFb_Q0C8TM3XZFLBi3ZqP2RbC2ovvAmZyUl31pnJmmSxC_54M4yIt14dzuF53wMPQm8YPWZMqLc2dhvXp27TD45wyjgRlNdcHlPO-RO0YlLpcpfyKVpRSgU50Vo_Ry9S2tJCay1W6FdB8Vm0_YTvw7AfIccDLsv15O2UE_7Z5w1uwvQAU5_tgK_AxozP-wQ2wTu8i0CwnRy-CymTz_v4ACV_mhKkNMJc0IRxZyM4nMMcHvLmMPflGIb0Ej3zdkjw6s88Ql8vPnxprsj60-V1c7omLeeSk4rS1msmqq5mnindVoo6rSonnetYrYUCXYBWemilUp1nFVhxUutWOy-ZF0fo9dK7i-HHHlI227CPU3lpmC4eKi0pK9T7hepiSCmCN7vYjzYeDKNmFm7-FW5m4WYRbmbhJU-WfJ8yPP4N2_jdqFrUlbm9b8y3s7vbm_XNhflYeL3w7bj9z1e_AQfXmfw</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Rhein, M von</creator><creator>Buchmann, A</creator><creator>Drexel, C</creator><creator>Hagmann, C</creator><creator>Batinic, K</creator><creator>Bertholdt, S</creator><creator>Bernet, V</creator><creator>Knirsch, W</creator><creator>Latal, B</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>201210</creationdate><title>222 Brain Volumetry in Infants with Congenital Heart Disease: pre- and Post-Surgery Assessments Compared to Healthy Controls</title><author>Rhein, M von ; Buchmann, A ; Drexel, C ; Hagmann, C ; Batinic, K ; Bertholdt, S ; Bernet, V ; Knirsch, W ; Latal, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2242-500bf8135c71f168b560d865d4ddc17836e8bf8b4feb466cf15ea3978b8df41f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Brain</topic><topic>Cardiovascular diseases</topic><topic>Control Groups</topic><topic>Neonates</topic><topic>Patients</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rhein, M von</creatorcontrib><creatorcontrib>Buchmann, A</creatorcontrib><creatorcontrib>Drexel, C</creatorcontrib><creatorcontrib>Hagmann, C</creatorcontrib><creatorcontrib>Batinic, K</creatorcontrib><creatorcontrib>Bertholdt, S</creatorcontrib><creatorcontrib>Bernet, V</creatorcontrib><creatorcontrib>Knirsch, W</creatorcontrib><creatorcontrib>Latal, B</creatorcontrib><creatorcontrib>Brain Research Heart and Group</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rhein, M von</au><au>Buchmann, A</au><au>Drexel, C</au><au>Hagmann, C</au><au>Batinic, K</au><au>Bertholdt, S</au><au>Bernet, V</au><au>Knirsch, W</au><au>Latal, B</au><aucorp>Brain Research Heart and Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>222 Brain Volumetry in Infants with Congenital Heart Disease: pre- and Post-Surgery Assessments Compared to Healthy Controls</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>2012-10</date><risdate>2012</risdate><volume>97</volume><issue>Suppl 2</issue><spage>A64</spage><epage>A64</epage><pages>A64-A64</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>Background and aims MRI studies in neonates with congenital heart disease (CHD) have demonstrated delayed brain maturation and mostly focal brain injury. To better define the distribution of cerebral injuries and regional brain growth in neonates with CHD, we compared volumetric measures from pre- and postoperative MRI of patients to healthy neonates. Methods Cerebral MRIs of 32 term-born CHD patients, scanned before and after heart surgery (mean age: 6.8 days and 26.8 days, respectively), were manually segmented to measure volumes of total, grey and white matter and of selected brain regions. Results were compared with MRIs of 17 healthy term born neonates (mean age: 23.5 days). Results Between pre- and postoperative MRI, patients showed significant brain growth, especially in the cortical grey matter (0.25%/day), cerebellum (0.20%/day), and deep gray matter structures (0.10–0.15%/day, all p<0.004). Volume increase of the white matter was 0.05–0.06%/day (left/right; p=0.017/0.003); increase of total brain volume was 0.14%/day (p<0.001). Compared to healthy controls, the size of all brain structures (except ventricles and right amygdala) was significantly reduced postoperatively. Largest differences were found in deep gray matter structures (13.8–16.8%, p=0.05-< 0.001), cortical grey (12.1%, p=0.01) and white matter (11.8%, p<0.001). Total brain volumes were reduced by 11.3% (p<0.001). Conclusions In neonates with CHD, significant differences of white and deep grey matter volumes were found postoperatively. Brain growth was high, with notable regional differences. Our results contribute to the knowledge on the timing of cerebral injury in neonates with CHD.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><doi>10.1136/archdischild-2012-302724.0222</doi><oa>free_for_read</oa></addata></record> |
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| title | 222 Brain Volumetry in Infants with Congenital Heart Disease: pre- and Post-Surgery Assessments Compared to Healthy Controls |
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