Long‐lasting extreme anemia during the therapy of acute lymphoblastic leukemia in a Jehovah's Witness patient
BACKGROUND The treatment of patients with acute leukemia, who due to their religious beliefs refuse to accept blood transfusion, is a great challenge for hematologists. CASE REPORT We present a case of acute pre‐T‐lymphoblastic leukemia in a Jehovah's Witness who did not accept blood transfusio...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2016-10, Vol.56 (10), p.2438-2442 |
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| container_title | Transfusion (Philadelphia, Pa.) |
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| creator | Chojnowski, Krzysztof Janus, Agnieszka Bliźniewska, Katarzyna Robak, Marta Treliński, Jacek |
| description | BACKGROUND
The treatment of patients with acute leukemia, who due to their religious beliefs refuse to accept blood transfusion, is a great challenge for hematologists.
CASE REPORT
We present a case of acute pre‐T‐lymphoblastic leukemia in a Jehovah's Witness who did not accept blood transfusion during chemotherapy. Standard induction and consolidation chemotherapy was used (according to the PALG ALL‐6 regiment).
RESULTS
During consolidation cycles, darbepoietin alfa, intravenous iron, and total parenteral nutrition was administered. Extreme (Hb |
| doi_str_mv | 10.1111/trf.13703 |
| format | Article |
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The treatment of patients with acute leukemia, who due to their religious beliefs refuse to accept blood transfusion, is a great challenge for hematologists.
CASE REPORT
We present a case of acute pre‐T‐lymphoblastic leukemia in a Jehovah's Witness who did not accept blood transfusion during chemotherapy. Standard induction and consolidation chemotherapy was used (according to the PALG ALL‐6 regiment).
RESULTS
During consolidation cycles, darbepoietin alfa, intravenous iron, and total parenteral nutrition was administered. Extreme (Hb < 5 g/dL), long‐lasting (41 days) anemia was observed with the lowest Hb concentration amounting to 1.3 g/dL (lasting 7 days).
CONCLUSION
We believe this to be the lowest Hb value observed, particularly one that persisted for such a long period of time and resulted in the patient surviving without consequences. The patient remains in complete remission for more than 2 years after diagnosis.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.13703</identifier><identifier>PMID: 27385671</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Anemia - chemically induced ; Anemia - therapy ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Blood Transfusion ; Darbepoetin alfa - therapeutic use ; Hematinics - therapeutic use ; Hemoglobins - analysis ; Humans ; Iron - administration & dosage ; Jehovah's Witnesses ; Male ; Parenteral Nutrition, Total ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Remission Induction ; Treatment Refusal ; Young Adult</subject><ispartof>Transfusion (Philadelphia, Pa.), 2016-10, Vol.56 (10), p.2438-2442</ispartof><rights>2016 AABB</rights><rights>2016 AABB.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3203-b6fc7f8f120608aeadc351dc47d8256cb44927d594705db9731a9d24f72f667e3</citedby><cites>FETCH-LOGICAL-c3203-b6fc7f8f120608aeadc351dc47d8256cb44927d594705db9731a9d24f72f667e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftrf.13703$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftrf.13703$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27385671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chojnowski, Krzysztof</creatorcontrib><creatorcontrib>Janus, Agnieszka</creatorcontrib><creatorcontrib>Bliźniewska, Katarzyna</creatorcontrib><creatorcontrib>Robak, Marta</creatorcontrib><creatorcontrib>Treliński, Jacek</creatorcontrib><title>Long‐lasting extreme anemia during the therapy of acute lymphoblastic leukemia in a Jehovah's Witness patient</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND
The treatment of patients with acute leukemia, who due to their religious beliefs refuse to accept blood transfusion, is a great challenge for hematologists.
CASE REPORT
We present a case of acute pre‐T‐lymphoblastic leukemia in a Jehovah's Witness who did not accept blood transfusion during chemotherapy. Standard induction and consolidation chemotherapy was used (according to the PALG ALL‐6 regiment).
RESULTS
During consolidation cycles, darbepoietin alfa, intravenous iron, and total parenteral nutrition was administered. Extreme (Hb < 5 g/dL), long‐lasting (41 days) anemia was observed with the lowest Hb concentration amounting to 1.3 g/dL (lasting 7 days).
CONCLUSION
We believe this to be the lowest Hb value observed, particularly one that persisted for such a long period of time and resulted in the patient surviving without consequences. The patient remains in complete remission for more than 2 years after diagnosis.</description><subject>Anemia - chemically induced</subject><subject>Anemia - therapy</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Blood Transfusion</subject><subject>Darbepoetin alfa - therapeutic use</subject><subject>Hematinics - therapeutic use</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Iron - administration & dosage</subject><subject>Jehovah's Witnesses</subject><subject>Male</subject><subject>Parenteral Nutrition, Total</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Remission Induction</subject><subject>Treatment Refusal</subject><subject>Young Adult</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1Kw0AQxxdRbK0efAFZ8CAe0u5Hkk2OUqwfFASpeAybZLZNzZe7GzU3H8Fn9ElMm-rNgWFg-M1_4IfQKSVj2tXEajWmXBC-h4bU48JhYejtoyEhLnUo5WyAjoxZE0JYSOghGjDBA88XdIiqeVUuvz-_cmlsVi4xfFgNBWBZQpFJnDZ6s7Ur2LSWdYsrhWXSWMB5W9SrKt5eJjiH5mV7kpVY4ntYVW9ydWHwc2ZLMAbX0mZQ2mN0oGRu4GQ3R-hpdr2Y3jrzh5u76dXcSTgj3Il9lQgVKMqITwIJMk24R9PEFWnAPD-JXTdkIvVCVxAvjUPBqQxT5irBlO8L4CN03ufWunptwNhoXTW67F5GNGCBy9wg4B112VOJrozRoKJaZ4XUbURJtFEbdWqjrdqOPdslNnEB6R_567IDJj3wnuXQ_p8ULR5nfeQPVESEfQ</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Chojnowski, Krzysztof</creator><creator>Janus, Agnieszka</creator><creator>Bliźniewska, Katarzyna</creator><creator>Robak, Marta</creator><creator>Treliński, Jacek</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>201610</creationdate><title>Long‐lasting extreme anemia during the therapy of acute lymphoblastic leukemia in a Jehovah's Witness patient</title><author>Chojnowski, Krzysztof ; Janus, Agnieszka ; Bliźniewska, Katarzyna ; Robak, Marta ; Treliński, Jacek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3203-b6fc7f8f120608aeadc351dc47d8256cb44927d594705db9731a9d24f72f667e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anemia - chemically induced</topic><topic>Anemia - therapy</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Blood Transfusion</topic><topic>Darbepoetin alfa - therapeutic use</topic><topic>Hematinics - therapeutic use</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Iron - administration & dosage</topic><topic>Jehovah's Witnesses</topic><topic>Male</topic><topic>Parenteral Nutrition, Total</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Remission Induction</topic><topic>Treatment Refusal</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chojnowski, Krzysztof</creatorcontrib><creatorcontrib>Janus, Agnieszka</creatorcontrib><creatorcontrib>Bliźniewska, Katarzyna</creatorcontrib><creatorcontrib>Robak, Marta</creatorcontrib><creatorcontrib>Treliński, Jacek</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chojnowski, Krzysztof</au><au>Janus, Agnieszka</au><au>Bliźniewska, Katarzyna</au><au>Robak, Marta</au><au>Treliński, Jacek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long‐lasting extreme anemia during the therapy of acute lymphoblastic leukemia in a Jehovah's Witness patient</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2016-10</date><risdate>2016</risdate><volume>56</volume><issue>10</issue><spage>2438</spage><epage>2442</epage><pages>2438-2442</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND
The treatment of patients with acute leukemia, who due to their religious beliefs refuse to accept blood transfusion, is a great challenge for hematologists.
CASE REPORT
We present a case of acute pre‐T‐lymphoblastic leukemia in a Jehovah's Witness who did not accept blood transfusion during chemotherapy. Standard induction and consolidation chemotherapy was used (according to the PALG ALL‐6 regiment).
RESULTS
During consolidation cycles, darbepoietin alfa, intravenous iron, and total parenteral nutrition was administered. Extreme (Hb < 5 g/dL), long‐lasting (41 days) anemia was observed with the lowest Hb concentration amounting to 1.3 g/dL (lasting 7 days).
CONCLUSION
We believe this to be the lowest Hb value observed, particularly one that persisted for such a long period of time and resulted in the patient surviving without consequences. The patient remains in complete remission for more than 2 years after diagnosis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27385671</pmid><doi>10.1111/trf.13703</doi><tpages>5</tpages></addata></record> |
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| issn | 0041-1132 1537-2995 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anemia - chemically induced Anemia - therapy Antineoplastic Combined Chemotherapy Protocols - therapeutic use Blood Transfusion Darbepoetin alfa - therapeutic use Hematinics - therapeutic use Hemoglobins - analysis Humans Iron - administration & dosage Jehovah's Witnesses Male Parenteral Nutrition, Total Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Remission Induction Treatment Refusal Young Adult |
| title | Long‐lasting extreme anemia during the therapy of acute lymphoblastic leukemia in a Jehovah's Witness patient |
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