The Transient Receptor Potential Vanilloid 1 Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia

Acute lung injury (ALI) caused by systemic inflammatory response remains a leading cause of morbidity and mortality in critically ill patients. Management of patients with sepsis is largely limited to supportive therapies, reflecting an incomplete understanding of the underlying pathophysiology. Fur...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2016-11, Vol.119 (5), p.421-427
Hauptverfasser:	Cabral, Layla D. M., Giusti‐Paiva, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - drug therapy Animals Capsaicin - analogs & derivatives Capsaicin - therapeutic use Disease Models, Animal Endotoxemia - drug therapy Lipopolysaccharides - toxicity Lung - drug effects Lung - pathology Male Mechanics Mice Respiratory system Rodents TRPV Cation Channels - antagonists & inhibitors
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