GW27-e0702 Toll-like receptor 7 expression and inflammation response in oxidized-low-density lipoprotein-stimulated macrophages

GW27-e0702 Toll-like receptor 7 expression and inflammation response in oxidized-low-density lipoprotein-stimulated macrophages

The TLR7 mRNA expression was analyzed by Real time-polymerase chain reaction and protein expression of TLR7, monocyte chemotactic protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1), interleukin-10 (IL-10) and degradation of IkBα were determined by Western-blot afterTHP-1-derived macropha...

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Veröffentlicht in:Journal of the American College of Cardiology 2016-10, Vol.68 (16), p.C27-C28
Hauptverfasser: Weijun, Huang, Hu, Gaifeng, Tong, Huiyu, Li, Meijun, Mai, Linlin, Chen, Dezhu, Tan, Jiaqi, Chen, Yingwen, Huang, Yuli, Hu, Yunzhao
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiovascular
Cell adhesion & migration
Internal Medicine
Ligands
Protein expression
Proteins
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Zusammenfassung:The TLR7 mRNA expression was analyzed by Real time-polymerase chain reaction and protein expression of TLR7, monocyte chemotactic protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1), interleukin-10 (IL-10) and degradation of IkBα were determined by Western-blot afterTHP-1-derived macrophages were stimulated with ox-LDL or co-incubated with a TLR7 ligand (imiquimod) or a transfected TLR7 siRNA.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2016.07.103