GW27-e0398 Mitogen-activated protein kinase interacting kinase 1 (Mnk1) Deficiency Aggravates Cardiac Remodeling via Regulation of Sprouty2-dependent ERK1/2 pathway

GW27-e0398 Mitogen-activated protein kinase interacting kinase 1 (Mnk1) Deficiency Aggravates Cardiac Remodeling via Regulation of Sprouty2-dependent ERK1/2 pathway

In line with the in vivo studies, Mnk1 knockdown by Mnk1 siRNA transfection resulted in exaggerated cardiomyocyte hypertrophy in Ang II-treated NRVMs. [...]adenovirus-mediated overexpression of Mnk1 in NRVMs protected cardiomyocytes from Ang II-induced hypertrophy.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of the American College of Cardiology 2016-10, Vol.68 (16), p.C16-C16
Hauptverfasser: Yuan, Yuan, Yan, Ling, Wu, Qing-Qing, Zhou, Heng, Jin, Ya-Ge, Bian, Zhou-Yan, Deng, Wei, Yang, Zheng, Shen, Di-Fei, Zeng, Xiao-Feng, Wang, Sha-Sha, Li, Hongliang, Tang, Qi-Zhu
Format: Artikel
Sprache:eng
Schlagworte:
Adenoviruses
Cardiology
Cardiomyocytes
Cardiovascular
Internal Medicine
Kinases
Phosphorylation
Rodents
Studies
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Zusammenfassung:In line with the in vivo studies, Mnk1 knockdown by Mnk1 siRNA transfection resulted in exaggerated cardiomyocyte hypertrophy in Ang II-treated NRVMs. [...]adenovirus-mediated overexpression of Mnk1 in NRVMs protected cardiomyocytes from Ang II-induced hypertrophy.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2016.07.061